HMG 75 IU<\/strong>\u00a0(Human Menopausal Gonadotropin) is a purified preparation containing a standardized 1:1 ratio of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). It is one of the most extensively studied gonadotropin preparations in reproductive endocrinology. At\u00a0china grey peptides company<\/strong>, we supply wholesale\u00a0HMG 75 IU<\/strong>\u00a0with verified >99% purity to research facilities across the USA, Canada, the United Kingdom, and Europe. This guide covers its mechanism, research applications, purity requirements, and safe handling \u2013 so you can make an informed wholesale purchase.<\/p>\n Human Menopausal Gonadotropin (HMG) is a gonadotropin preparation extracted from the urine of postmenopausal women, where FSH and LH production is naturally elevated. Modern HMG preparations contain\u00a075 IU of FSH and 75 IU of LH<\/strong>\u00a0per vial \u2013 a balanced 1:1 ratio that provides comprehensive stimulation of gonadal tissues. The first clinically usable form of HMG was isolated by Piero Donini in 1949 and introduced into use by Bruno Lunenfeld in 1961. Today, highly purified HMG (HP-hMG) is suitable for precise laboratory handling.<\/p>\n The mechanism of action follows the two-cell, two\u2011gonadotropin model of follicular steroidogenesis:<\/p>\n FSH<\/strong>\u00a0targets granulosa cells in the ovaries, promoting follicular development and estrogen production<\/p>\n<\/li>\n LH<\/strong>\u00a0acts on theca cells, stimulating androgen production (androstenedione and testosterone)<\/p>\n<\/li>\n Together, they drive follicular growth, steroidogenesis, and \u2013 when combined with appropriate triggers \u2013 ovulation.<\/p>\n<\/li>\n<\/ul>\n Upon administration, HMG binds to FSH and LH receptors on target cells, activating cyclic adenosine monophosphate (cAMP) signaling pathways. This triggers a cascade leading to follicular growth, maturation, and eventual ovulation in appropriate models. The balanced FSH and LH content provides comprehensive gonadotropic stimulation, often resulting in more physiological hormone profiles compared to single-hormone preparations.<\/p>\n Pharmacokinetically, HMG demonstrates excellent bioavailability when administered subcutaneously or intramuscularly. Peak serum concentrations are typically achieved within 12-24 hours, with a half\u2011life ranging from 24-36 hours \u2013 allowing for convenient dosing schedules.<\/p>\n Follicular Development Studies<\/strong>\u00a0\u2013 Investigates the role of balanced FSH\/LH stimulation in ovarian folliculogenesis<\/p>\n<\/li>\n Spermatogenesis Research<\/strong>\u00a0\u2013 Studies testicular steroidogenesis and sperm production cycles<\/p>\n<\/li>\n Ovarian Stimulation Protocols<\/strong>\u00a0\u2013 Evaluates different gonadotropin combinations in ART models<\/p>\n<\/li>\n Endometrial Receptivity<\/strong>\u00a0\u2013 Explores the relationship between gonadotropin ratios and endometrial thickness<\/p>\n<\/li>\n PCOS Models<\/strong>\u00a0\u2013 Examines predictable responses to precise hormonal regulation<\/p>\n<\/li>\n Two\u2011Cell Theory Validation<\/strong>\u00a0\u2013 Tests the classical model of follicular steroidogenesis<\/p>\n<\/li>\n<\/ul>\n \u26a0\ufe0f\u00a0Research use only<\/strong>\u00a0\u2013 HMG is not approved for human therapeutic use as a research chemical. It is strictly for\u00a0in vitro and laboratory animal studies<\/strong>. WADA classifies HMG as a prohibited substance under\u00a0Section S2 (Peptide Hormones, Growth Factors, and Related Substances)<\/strong>. Gonadotrophins (LH, hCG) are listed as prohibited in both men and women.<\/p>\n<\/blockquote>\n We understand that\u00a0peptide purity<\/strong>\u00a0directly affects receptor binding assays, cell signaling studies, and in vivo models. Here is what we guarantee:<\/p>\n No Impurities<\/strong>\u00a0\u2013 Single peak by HPLC; each batch is assayed for IU potency of both FSH and LH fractions<\/p>\n<\/li>\n Batch Traceability<\/strong>\u00a0\u2013 Each COA includes retention time, purity %, and residual solvent analysis<\/p>\n<\/li>\n Low Endotoxin<\/strong>\u00a0\u2013 <1 EU\/mg for cell culture applications<\/p>\n<\/li>\n Manufactured under cGMP conditions<\/strong>\u00a0to ensure high bioactivity and purity<\/p>\n<\/li>\n Vacuum\u2011Sealed Vials<\/strong>\u00a0\u2013 Prevent moisture absorption and maintain stability<\/p>\n<\/li>\n Fast Turnaround<\/strong>\u00a0\u2013 Orders ship within 24 hours on business days<\/p>\n<\/li>\n<\/ul>\n Staying current with peer\u2011reviewed literature is part of our\u00a0E\u2011E\u2011A\u2011T<\/strong>\u00a0commitment. Here are key recent findings:<\/p>\n A 2024 study published in the\u00a0Journal of Obstetrics and Gynaecology Research<\/em>\u00a0compared LH supplementation with hMG versus low\u2011dose hCG during ovarian stimulation. The study analyzed 468 unique stimulation cycles (hMG: 75\u2013250 IU; low\u2011dose hCG: 50\u2013100 IU). Results showed that fresh and frozen IVF\u2011ET pregnancy outcomes were comparable after hMG versus low\u2011dose hCG supplementation, suggesting flexibility in supplemental LH dosing regimens that may address research preference or cost concerns.<\/p>\n A 2024 study in the\u00a0International Journal of Women\u2018s Health<\/em>\u00a0enrolled 456 infertile women undergoing IVF\/ICSI. The study found that the addition of both HMG and recombinant LH (r-LH) to FSH improved pregnancy and birth outcomes, particularly in women over 32 years of age or with overweight\/obesity \u2013 groups that typically face challenges in conceiving and sustaining a pregnancy. Endometrial thickness was greater in the HMG\u2011supplemented groups, suggesting better endometrial receptivity.<\/p>\n Data from a published study (PMC7137506) showed that HMG dosage (75 IU\/vial) was associated with improved endometrial thickness and estradiol levels when vitamin E was supplemented from the follicular phase. The research tracked ovulation rates (71.4\u201177.3%) and clinical pregnancy rates (23.6\u201128.2%) across different supplementation protocols.<\/p>\n A comprehensive 30\u2011year review published in\u00a0Reproductive BioMedicine Online<\/em>\u00a0(June 2025) evaluated the effect of HCG and LH supplementation during ovarian stimulation. The review found that while r\u2011FSH appeared more potent than urinary FSH, HMG recruited fewer follicles but resulted in slightly higher pregnancy rates after a first fresh embryo transfer. The conclusion noted that the beneficial effect of HCG and LH supplementation on clinical outcome has never been definitely proven for any of the combined gonadotropin products, highlighting the need for continued research.<\/p>\n A randomized controlled trial demonstrated that ovarian stimulation with low\u2011dose hMG (starting at 75 IU\/day) is superior to clomiphene citrate in intrauterine insemination cycles with respect to clinical pregnancy rate. This suggests better reproductive outcomes after ovarian stimulation with low\u2011dose gonadotropins.<\/p>\n If your lab needs a reliable supply of\u00a0HMG 75 IU<\/strong>, follow these steps:<\/p>\n We sell only to qualified research institutions, laboratories, and registered businesses. Provide a valid tax ID or institutional email.<\/p>\n Before ordering, ask for the\u00a0Certificate of Analysis<\/strong>\u00a0for the batch you will receive. Look for:<\/p>\n Purity \u226599% by HPLC<\/p>\n<\/li>\n IU potency of both FSH and LH fractions<\/p>\n<\/li>\n Low endotoxin levels (<1 EU\/mg)<\/p>\n<\/li>\n<\/ul>\n We offer wholesale from 10 vials up to 1,000+ vials. Contact us for bulk pricing.<\/p>\n Use the form below or email\u00a0sales@chinagreypeptidescompany.com<\/strong>. We ship within 24 hours on business days.<\/p>\n HMG 75 IU (Human Menopausal Gonadotropin) is a purified gonadotropin preparation containing\u00a075 IU of follicle-stimulating hormone (FSH) and 75 IU of luteinizing hormone (LH)<\/strong>\u00a0in a 1:1 ratio \u2013 the classic standard preparation. It is extensively studied in reproductive endocrinology for its role in gametogenesis and steroidogenesis.<\/p>\n HMG binds to FSH and LH receptors on ovarian and testicular cells, activating cAMP signaling pathways. FSH promotes follicular development, while LH stimulates androgen production \u2013 together driving gametogenesis and steroidogenesis in a coordinated manner.<\/p>\n Research protocols vary widely. Standard initial dosing in animal models typically ranges from\u00a075-150 IU daily<\/strong>, administered subcutaneously or intramuscularly. In published studies, HMG dosages of 75\u2011250 IU have been used during stimulation cycles. Always design your own protocol based on published literature.<\/p>\n Add sterile bacteriostatic water or 0.9% saline to the vial. Gently swirl \u2013 do not shake. Store reconstituted HMG at 2\u20118\u00b0C for up to 4 weeks, or freeze in aliquots at \u201320\u00b0C for up to 6 months. The lyophilized powder is stable for up to 24 months when stored at \u201320\u00b0C.<\/p>\n Yes, for\u00a0research purposes only<\/strong>. It is not a controlled substance but is prohibited in athletic competition by WADA under Section S2 (Peptide Hormones). You must not use it in humans.<\/p>\n Yes. We ship to all research addresses in\u00a0Canada, United Kingdom, and Europe<\/strong>\u00a0with proper customs documentation. Import permits may be required \u2013 please check local regulations.<\/p>\n The CAS number for HMG 75 IU is\u00a090779-69-4<\/strong>.<\/p>\n HMG contains both FSH and LH in a 1:1 ratio, mimicking the body\u2019s natural gonadotropin balance. r\u2011FSH contains only FSH. Research shows that HMG recruits fewer follicles but may result in slightly higher pregnancy rates after fresh embryo transfer, possibly due to the LH component.<\/p>\n Link from the FAQ to your\u00a0\u201cCertificate of Analysis \u2013 https:\/\/chinagreypeptidescompany.com\/about-us\/<\/strong><\/p>\n<\/li>\n Link from the\u00a0\u201cHow to Buy\u201d<\/strong>\u00a0section to your\u00a0\u201cWholesale Inquiry Form\u201d<\/strong>\u00a0page<\/a><\/p>\n<\/li>\n<\/ol>\n PubMed \u2013 30\u2011Year Review of HCG\/LH Supplementation (2025)<\/strong> WADA 2026 Prohibited List \u2013 S2 Peptide Hormones<\/strong>What Is HMG 75 IU? (Mechanism of Action)<\/h2>\n
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Key Research Effects of HMG 75 IU<\/h3>\n
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Why Choose china grey peptides company for HMG 75 IU?<\/h2>\n
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\n \nFeature<\/th>\n Our Standard<\/th>\n<\/tr>\n<\/thead>\n \n Purity<\/td>\n >99%<\/strong>\u00a0by HPLC<\/td>\n<\/tr>\n \n Composition<\/td>\n FSH and LH in 1:1 ratio (75 IU each)<\/td>\n<\/tr>\n \n Format<\/td>\n Lyophilized powder<\/td>\n<\/tr>\n \n Storage<\/td>\n \u201320\u00b0C (long\u2011term); shipped with ice packs<\/td>\n<\/tr>\n \n Documentation<\/td>\n Certificate of Analysis (COA) for every batch<\/td>\n<\/tr>\n \n Shipping<\/td>\n USA, Canada, UK, Europe \u2013 wholesale only<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n Our Quality Promise<\/h3>\n
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Recent Research on HMG 75 IU (2024\u20132025)<\/h2>\n
\ud83e\uddec LH Supplementation in IVF (2024)<\/h3>\n
\ud83e\uddec HMG + r-LH Improves Pregnancy Outcomes (2024)<\/h3>\n
\ud83e\uddec HMG Dosage and Ovarian Response (PMC)<\/h3>\n
\ud83e\uddec 30\u2011Year Review of HCG\/LH Supplementation (2025)<\/h3>\n
\ud83e\uddec Low\u2011Dose HMG Superior to Clomiphene<\/h3>\n
How to Buy HMG 75 IU for Research (Wholesale)<\/h2>\n
1. Verify Your Research Status<\/h3>\n
2. Request the Current COA<\/h3>\n
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3. Choose Your Quantity<\/h3>\n
4. Place Your Order<\/h3>\n
Frequently Asked Questions (FAQ)<\/h2>\n
\u2753 What is HMG 75 IU?<\/h3>\n
\u2753 How does HMG 75 IU work?<\/h3>\n
\u2753 What is the typical dosage of HMG in research studies?<\/h3>\n
\u2753 How do I reconstitute HMG 75 IU?<\/h3>\n
\u2753 Is HMG 75 IU legal to buy in the USA?<\/h3>\n
\u2753 Do you ship to Canada, UK, or Europe?<\/h3>\n
\u2753 What is the CAS number for HMG 75 IU?<\/h3>\n
\u2753 What is the difference between HMG and recombinant FSH (r\u2011FSH)?<\/h3>\n
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\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/40294495\/<\/a><\/p>\n<\/li>\n
\nhttps:\/\/www.wada-ama.org\/en\/prohibited-list<\/a><\/p>\n<\/li>\n