{"id":845,"date":"2026-05-25T03:49:50","date_gmt":"2026-05-25T03:49:50","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&p=845"},"modified":"2026-07-11T17:41:03","modified_gmt":"2026-07-11T17:41:03","slug":"adipotide-ftpp-10mg","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/adipotide-ftpp-10mg\/","title":{"rendered":"Adipotide (FTPP) (10mg)"},"content":{"rendered":"

Adipotide (FTPP) (10mg) Research Peptide: A Targeted Proapoptotic Peptide for Adipose & Metabolic Studies<\/span><\/h2>\n

If your research investigates adipose tissue biology, vascular targeting, or the molecular mechanisms underlying metabolic regulation,\u00a0<\/span>Adipotide (FTPP) (10mg) research peptide<\/span><\/strong>\u00a0offers a precisely defined synthetic tool with a unique and well\u2011characterised mechanism of action. Also known as FTPP (Fat\u2011Targeted Proapoptotic Peptide), Prohibitin\u2011Targeting Peptide\u20111 (TP01), and HKPao, Adipotide is a bipartite peptidomimetic designed to selectively target the vasculature of white adipose tissue<\/span>. It consists of a homing domain that binds to a prohibitin\u2011annexin A2 complex on adipose endothelial cells, coupled to a proapoptotic effector domain that disrupts mitochondrial membranes, leading to endothelial cell apoptosis and subsequent vascular ablation<\/span>. This makes\u00a0<\/span>Adipotide (FTPP) (10mg) research peptide<\/span><\/strong>\u00a0a valuable tool for laboratories investigating adipose tissue remodelling, obesity pathophysiology, angiogenesis, and metabolic disease.<\/span><\/p>\n

At\u00a0<\/span>Wuhan Top Miracle Peptides<\/span><\/strong>, we supply high\u2011purity\u00a0<\/span>Adipotide (FTPP) (10mg) research peptide<\/span><\/strong>\u00a0to research institutions and wholesale buyers across the\u00a0<\/span>United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong>. Every batch is lyophilised, HPLC\u2011verified to \u226598% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into adipose biology, metabolic regulation, and vascular targeting begin with uncompromising quality.<\/span><\/p>\n

What Is Adipotide (FTPP) and How Does It Work?<\/span><\/h2>\n

To fully appreciate the research potential of\u00a0<\/span>Adipotide (FTPP) (10mg) research peptide<\/span><\/strong>, it is essential to understand its biochemical structure and the precise mechanism by which it exerts its effects.<\/span><\/p>\n

The Bipartite Peptidomimetic Structure<\/span><\/h3>\n

Adipotide is a synthetic bipartite molecule composed of two functional domains linked by a diglycine spacer<\/span>. Its sequence is\u00a0<\/span>H\u2011Cys\u2011Lys\u2011Gly\u2011Gly\u2011Arg\u2011Ala\u2011Lys\u2011Asp\u2011Cys\u2011Gly\u2011Gly\u2011(D\u2011Lys\u2011Leu\u2011Ala\u2011Lys\u2011Leu\u2011Ala\u2011Lys)\u2082\u2011NH\u2082<\/span><\/strong>, with a disulfide bridge forming a cyclic structure<\/span>. The molecular formula is\u00a0<\/span>C\u2081\u2081\u2081H\u2082\u2080\u2086N\u2083\u2086O\u2082\u2088S\u2082<\/span><\/strong>, with a molecular weight of approximately\u00a0<\/span>2557.21 Da<\/span><\/strong>. It has a CAS number of\u00a0<\/span>859216\u201115\u20112<\/span><\/strong>.<\/span><\/p>\n

The peptide originated from the laboratory of Renata Pasqualini and Wadih Arap at the M.D. Anderson Cancer Center, building on a 2004\u00a0<\/span>Nature Medicine<\/span><\/em>\u00a0paper that used phage\u2011display technology to screen for peptide sequences homing to white adipose vasculature<\/span>. The approach builds on an earlier 1999 proof\u2011of\u2011concept demonstrating that a vascular\u2011homing peptide could be coupled to a proapoptotic effector domain to kill targeted endothelial cells<\/span>.<\/span><\/p>\n

Mechanism of Action: Vascular Targeting and Endothelial Apoptosis<\/span><\/h3>\n

The biological activity of\u00a0<\/span>Adipotide (FTPP) (10mg) research peptide<\/span><\/strong>\u00a0is mediated through its unique bipartite design:<\/span><\/p>\n

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    Targeting Domain (CKGGRAKDC):<\/span><\/strong>\u00a0The nine\u2011amino\u2011acid homing sequence CKGGRAKDC binds selectively to a protein complex involving\u00a0<\/span>prohibitin (PHB)<\/span><\/strong>\u00a0and\u00a0<\/span>annexin A2 (ANXA2)<\/span><\/strong>\u00a0on the luminal surface of endothelial cells feeding white adipose tissue<\/span>. This receptor complex is enriched on adipose vasculature and plays a role in fatty acid transport<\/span>.<\/span><\/p>\n<\/li>\n

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    Proapoptotic Effector Domain (D(KLAKLAK)\u2082):<\/span><\/strong>\u00a0Once internalised into endothelial cells, the effector domain disrupts mitochondrial membranes, triggering programmed cell death (apoptosis)<\/span>.<\/span><\/p>\n<\/li>\n

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    Vascular Ablation and Adipose Tissue Reduction:<\/span><\/strong>\u00a0The apoptotic death of adipose vasculature leads to vasoconstriction and shutdown of microvasculature within adipose tissue<\/span>. This cuts off the blood supply \u2014 and therefore oxygen and nutrients \u2014 to white adipocytes, causing fat cells to wither and die<\/span>. In preclinical studies, Adipotide resulted in approximately\u00a0<\/span>30% weight reduction<\/span><\/strong>\u00a0in obese mice over a period of 4 weeks<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

    Receptor Interactions and Fatty Acid Transport<\/span><\/h3>\n

    Beyond vascular targeting, Adipotide\u2019s mechanism is intertwined with recent findings about PHB and ANXA2 roles in fatty acid transport<\/span>. The PHB\u2011ANXA2 interaction is present not only on vascular endothelium but also on adipocytes themselves. Disruption of PHB\u2011ANXA2 binding appears to reduce fatty acid uptake into adipose depots via the fatty acid transporter\u00a0<\/span>CD36<\/span><\/strong>. This suggests that Adipotide may indirectly modulate lipid influx into adipose tissue by targeting this network<\/span>.<\/span><\/p>\n

    Research Note: A Distinct Mechanism from Incretin\u2011Based Approaches<\/span><\/h3>\n

    Unlike GLP\u20111 receptor agonists or other central\u2011acting weight loss peptides, Adipotide does not target appetite or the central nervous system<\/span>. Instead, it acts\u00a0<\/span>directly on adipose tissue<\/span><\/strong>\u00a0by disrupting its blood supply<\/span>. This distinct mechanism of action \u2014 adipocytes are the target, apoptosis being the means to achieve fat reduction \u2014 positions Adipotide as a valuable tool for studying adipose biology through a pathway that is mechanistically orthogonal to incretin\u2011based therapies<\/span>.<\/span><\/p>\n

    Key Research Applications for Adipotide (FTPP) (10mg)<\/span><\/h2>\n

    Adipotide (FTPP) (10mg) research peptide<\/span><\/strong>\u00a0is a versatile tool with applications spanning several domains of biomedical research<\/span>.<\/span><\/p>\n

    1. Adipose Tissue Biology & Obesity Research<\/span><\/h3>\n

    As a peptide that selectively targets the vasculature of white adipose tissue, Adipotide is a valuable tool for studying adipose biology and obesity pathophysiology<\/span>. Research applications include:<\/span><\/p>\n

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      Adipose Tissue Remodelling:<\/span><\/strong>\u00a0Investigating how vascular ablation leads to adipose tissue mass reduction and altered adipocyte function<\/span>.<\/span><\/p>\n<\/li>\n

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      Subcutaneous vs. Visceral Fat:<\/span><\/strong>\u00a0Exploring the differential targeting of subcutaneous and visceral fat depots<\/span>.<\/span><\/p>\n<\/li>\n

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      Energy Homeostasis:<\/span><\/strong>\u00a0Studying the role of adipose vasculature in energy balance and metabolic regulation<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

      2. Metabolic & Diabetes Research<\/span><\/h3>\n

      Adipotide has demonstrated significant effects on metabolic parameters in preclinical models. Research applications include:<\/span><\/p>\n

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        Insulin Sensitivity:<\/span><\/strong>\u00a0Investigating how Adipotide improves glucose tolerance and insulin sensitivity. In obese adult mice, Adipotide treatment resulted in significantly improved insulin sensitivity and enhanced polysaccharide tolerance<\/span>.<\/span><\/p>\n<\/li>\n

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        Serum Triglycerides:<\/span><\/strong>\u00a0Studies have shown reduced serum triglycerides following Adipotide treatment<\/span>.<\/span><\/p>\n<\/li>\n

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        Type 2 Diabetes Models:<\/span><\/strong>\u00a0Exploring the peptide’s potential as a research tool for understanding the relationship between adipose tissue and diabetes<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

        3. Angiogenesis & Vascular Research<\/span><\/h3>\n

        Adipotide’s reliance on vascular disruption positions it as a research tool for exploring angiogenesis in adipose and other tissues<\/span>. Research applications include:<\/span><\/p>\n