{"id":874,"date":"2026-05-25T03:49:57","date_gmt":"2026-05-25T03:49:57","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&#038;p=874"},"modified":"2026-06-24T18:02:16","modified_gmt":"2026-06-24T18:02:16","slug":"foxo4-dri-10mg","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/foxo4-dri-10mg\/","title":{"rendered":"FOXO4-DRI (10mg)"},"content":{"rendered":"<h1><span class=\"\">FOXO4-DRI (10mg) Research Peptide: A Senolytic Peptide for Cellular Senescence &amp; Aging Studies<\/span><\/h1>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">If your research investigates the molecular mechanisms of cellular senescence, the biology of aging, or the selective elimination of damaged cells,\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0offers a precisely defined and increasingly well\u2011characterised synthetic tool. FOXO4-DRI is a cell\u2011permeable,\u00a0<\/span><strong><span class=\"\">D\u2011retro\u2011inverso (DRI) peptide<\/span><\/strong><span class=\"\">\u00a0derived from the forkhead box O4 (FOXO4) transcription factor<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\"> It was first reported in a landmark 2017 study by Baar et al. in\u00a0<\/span><em><span class=\"\">Cell<\/span><\/em><span class=\"\">, which demonstrated that the peptide could selectively induce apoptosis in senescent cells and restore tissue homeostasis in response to chemotoxicity and aging<\/span><span class=\"\">. By specifically disrupting the protein\u2011protein interaction between FOXO4 and the tumour suppressor p53, FOXO4-DRI enables researchers to study the role of the FOXO4\u2011p53 axis in maintaining the viability of senescent cells<\/span><span class=\"\">. This makes\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0a valuable tool for laboratories investigating cellular senescence, aging biology, apoptosis pathways, and regenerative medicine.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">At\u00a0<\/span><strong><span class=\"\">Wuhan Top Miracle Peptides<\/span><\/strong><span class=\"\">, we supply high\u2011purity\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0to research institutions and wholesale buyers across the\u00a0<\/span><strong><span class=\"\">United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong><span class=\"\">. Every batch is lyophilised, HPLC\u2011verified to \u226598% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into senescence, aging, and apoptosis begin with uncompromising quality.<\/span><\/p>\n<h2><span class=\"\">What Is FOXO4-DRI and How Does It Work?<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">To fully appreciate the research potential of\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">, it is essential to understand its biochemical design and the precise mechanism by which it exerts its selective senolytic effects.<\/span><\/p>\n<h3><span class=\"\">The D\u2011Retro\u2011Inverso Peptide<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">FOXO4-DRI is a synthetic peptide composed entirely of\u00a0<\/span><strong><span class=\"\">D\u2011amino acids<\/span><\/strong><span class=\"\">\u00a0in a retro\u2011inverso configuration<\/span><span class=\"\">. Its sequence is\u00a0<\/span><strong><span class=\"\">D\u2011(LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRPPPRRRQRRKKRG)<\/span><\/strong><span class=\"\">. The peptide is 46 amino acids in length<\/span><span class=\"\">, with a molecular formula of\u00a0<\/span><strong><span class=\"\">C\u2082\u2082\u2088H\u2083\u2088\u2088N\u2088\u2086O\u2086\u2084<\/span><\/strong><span class=\"\">\u00a0and a molecular weight of approximately\u00a0<\/span><strong><span class=\"\">5358.05 Da<\/span><\/strong><span class=\"\">. It has a CAS number of\u00a0<\/span><strong><span class=\"\">2460055\u201110\u20119<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The peptide incorporates a\u00a0<\/span><strong><span class=\"\">cell\u2011penetrating sequence<\/span><\/strong><span class=\"\">\u00a0derived from the HIV\u2011TAT protein, which facilitates its entry into cells<\/span><span class=\"\">. The D\u2011retro\u2011inverso configuration confers enhanced resistance to proteolytic degradation, making the peptide more stable in biological systems compared to L\u2011amino acid peptides.<\/span><\/p>\n<h3><span class=\"\">Mechanism of Action: Selective Senolytic Activity via FOXO4\u2011p53 Disruption<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The biological activity of\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0is mediated through its targeted disruption of the FOXO4\u2011p53 protein\u2011protein interaction:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">FOXO4\u2011p53 Axis Disruption:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI specifically disrupts the interaction between FOXO4 and p53<\/span><span class=\"\">. In senescent cells, FOXO4 binds p53 in the nucleus, preventing p53 from inducing apoptosis and maintaining the senescent cell in a state of growth arrest<\/span><span class=\"\">. FOXO4-DRI displaces FOXO4 from p53, breaking this interaction<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">p53 Nuclear Exclusion:<\/span><\/strong><span class=\"\">\u00a0By disrupting the FOXO4\u2011p53 complex, FOXO4-DRI facilitates the\u00a0<\/span><strong><span class=\"\">nuclear export of phosphorylated p53<\/span><\/strong><span class=\"\">. This relocalisation of p53 away from the nucleus is a critical step in triggering apoptosis<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Activation of the p53\/BCL\u20112\/Caspase\u20113 Pathway:<\/span><\/strong><span class=\"\">\u00a0The nuclear exclusion of phosphorylated p53 subsequently triggers the activation of\u00a0<\/span><strong><span class=\"\">BAX and cleaved caspase\u20113<\/span><\/strong><span class=\"\">, leading to the activation of the\u00a0<\/span><strong><span class=\"\">p53\/BCL\u20112\/Caspase\u20113 signalling pathway<\/span><\/strong><span class=\"\">. This cascade promotes the\u00a0<\/span><strong><span class=\"\">selective apoptosis of senescent cells<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Reduction of Senescence\u2011Associated Secretory Phenotype (SASP):<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI reduces the secretion of the senescence\u2011associated secretory phenotype (SASP) from senescent cells<\/span><span class=\"\">, which in turn improves the surrounding cellular microenvironment<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"\">Key Research Applications for FOXO4-DRI (10mg)<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0is a versatile tool with applications spanning several domains of biomedical research.<\/span><\/p>\n<h3><span class=\"\">1. Cellular Senescence &amp; Aging Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The most established application of FOXO4-DRI lies in its ability to serve as a selective senolytic agent for studying cellular senescence and aging. Research has demonstrated:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Endothelial Cell Senescence:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI induces apoptosis in senescent endothelial cells and significantly improves vascular function, delaying vascular aging<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Vascular Aging Models:<\/span><\/strong><span class=\"\">\u00a0Injection of FOXO4-DRI in naturally aged and induced aging mice effectively suppressed aortic aging and improved aortic function<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Testicular Aging:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI improves spermatogenesis in aged mice by reducing SASP secretion from senescent Leydig cells<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Age\u2011Related Testosterone Decline:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI alleviates age\u2011related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">2. Fibrosis &amp; Scarring Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">FOXO4-DRI has demonstrated potential in fibrosis and scarring research:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Pulmonary Fibrosis:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI decreases senescent cells and attenuates bleomycin\u2011induced morphological changes and collagen deposition in mouse models<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Keloid Research:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI promotes apoptosis in keloid senescent fibroblasts by promoting nuclear exclusion of upregulated p53\u2011serine 15 phosphorylation<\/span><span class=\"\">. This highlights the role of the senescent microenvironment in keloid overgrowth and relapse<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">3. Cartilage &amp; Osteoarthritis Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">FOXO4-DRI has been investigated for its potential in cartilage research:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Chondrocyte Senescence:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI selectively removes senescent cells from\u00a0<\/span><em><span class=\"\">in vitro<\/span><\/em><span class=\"\">\u00a0expanded human chondrocytes, potentially enhancing their potential for generating high\u2011quality cartilage<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">4. Apoptosis &amp; Signal Transduction Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">As a precise modulator of the FOXO4\u2011p53 interaction, FOXO4-DRI serves as a research tool for dissecting apoptosis pathways:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Apoptosis Pathway Investigation:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI is instrumental in dissecting the molecular determinants of programmed cell death<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Signal Transduction Analysis:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI serves as a precise modulator for delineating the downstream effects of FOXO transcription factors and studying the cross\u2011talk between stress response pathways and apoptotic regulators<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">5. Senolytic &amp; Anti\u2011Senescence Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">FOXO4-DRI is widely utilised in studies investigating the molecular mechanisms underlying cellular senescence<\/span><span class=\"\">:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Selective Senescent Cell Elimination:<\/span><\/strong><span class=\"\">\u00a0By selectively interfering with the endogenous FOXO4\u2011p53 binding, the peptide enables researchers to induce targeted disruption of senescence\u2011associated signalling pathways<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Tissue Homeostasis Studies:<\/span><\/strong><span class=\"\">\u00a0FOXO4-DRI facilitates studies aimed at understanding how the accumulation or removal of senescent cells impacts aging phenotypes and tissue regeneration<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"\">Chemical &amp; Physical Specifications<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Accurate characterisation of\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0is essential for reproducible experimental design.<\/span><\/p>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Parameter<\/span><\/th>\n<th><span class=\"\">Specification<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong><span class=\"\">Common Names<\/span><\/strong><\/td>\n<td><span class=\"\">FOXO4-DRI, FOXO4 D-Retro-Inverso peptide<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Amino Acid Sequence<\/span><\/strong><\/td>\n<td><span class=\"\">D\u2011(LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRPPPRRRQRRKKRG)<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Molecular Formula<\/span><\/strong><\/td>\n<td><span class=\"\">C\u2082\u2082\u2088H\u2083\u2088\u2088N\u2088\u2086O\u2086\u2084<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Molecular Weight<\/span><\/strong><\/td>\n<td><span class=\"\">~5358.05 Da<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">CAS Number<\/span><\/strong><\/td>\n<td><span class=\"\">2460055\u201110\u20119<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Purity<\/span><\/strong><\/td>\n<td><strong><span class=\"\">\u226598%<\/span><\/strong><span class=\"\">\u00a0(HPLC verified)<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Appearance<\/span><\/strong><\/td>\n<td><span class=\"\">White to off\u2011white lyophilised powder<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Solubility<\/span><\/strong><\/td>\n<td><span class=\"\">Soluble in sterile water and sterile PBS (pH 5\u20117); also soluble in DMSO<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Storage (Lyophilised)<\/span><\/strong><\/td>\n<td><span class=\"\">\u201320\u00b0C, sealed, protected from light; stable for up to 3 years<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Storage (Reconstituted)<\/span><\/strong><\/td>\n<td><span class=\"\">2\u20118\u00b0C for short\u2011term use; single\u2011use aliquots at \u201320\u00b0C for up to 6 months<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<blockquote>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Note:<\/span><\/strong><span class=\"\">\u00a0The 10\u202fmg mass refers to the weight of the peptide in its lyophilised form. FOXO4-DRI is typically supplied as a TFA or acetate salt, which enhances aqueous solubility<\/span><span class=\"\">. The peptide contains a cell\u2011penetrating sequence derived from HIV\u2011TAT<\/span><span class=\"\">.<\/span><\/p>\n<\/blockquote>\n<h2><span class=\"\">Reconstitution &amp; Handling Protocol for FOXO4-DRI (10mg)<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Proper reconstitution of\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0is critical for maintaining its structural integrity and biological activity. The D\u2011retro\u2011inverso configuration confers enhanced stability, but standard peptide handling precautions should still be observed.<\/span><\/p>\n<h3><span class=\"\">Step 1 \u2013 Preparation<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Bring the sealed FOXO4-DRI vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH\u202f5\u20117) to room temperature.\u00a0<\/span><em><span class=\"\">Condensation can degrade the lyophilised powder.<\/span><\/em><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 2 \u2013 Vial Sanitisation<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Wipe the rubber stopper of the FOXO4-DRI vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 3 \u2013 Reconstitution<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is\u00a0<\/span><strong><span class=\"\">10\u202fmg per 1\u202fmL of diluent<\/span><\/strong><span class=\"\">, yielding a\u00a0<\/span><strong><span class=\"\">10\u202fmg\/mL<\/span><\/strong><span class=\"\">\u00a0stock solution.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Insert the needle and slowly inject the diluent\u00a0<\/span><strong><span class=\"\">against the inner glass wall<\/span><\/strong><span class=\"\">. Do not spray directly onto the lyophilised powder.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Gently swirl the vial until the solution is clear and fully dissolved.\u00a0<\/span><strong><span class=\"\">Do not shake vigorously<\/span><\/strong><span class=\"\">, as shaking can cause denaturation.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 4 \u2013 Aliquoting &amp; Storage<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Immediately after dissolution, aliquot the reconstituted FOXO4-DRI into single\u2011use sterile vials.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Store aliquots at \u201320\u00b0C.\u00a0<\/span><strong><span class=\"\">Avoid repeated freeze\u2011thaw cycles<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Once thawed, store at 2\u20118\u00b0C and use within a short period.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Concentration Reference Table<\/span><\/h3>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Vial Mass<\/span><\/th>\n<th><span class=\"\">Diluent Volume<\/span><\/th>\n<th><span class=\"\">Final Concentration<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"\">10\u202fmg<\/span><\/td>\n<td><span class=\"\">1.0\u202fmL<\/span><\/td>\n<td><span class=\"\">10\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">10\u202fmg<\/span><\/td>\n<td><span class=\"\">2.0\u202fmL<\/span><\/td>\n<td><span class=\"\">5\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">10\u202fmg<\/span><\/td>\n<td><span class=\"\">0.5\u202fmL<\/span><\/td>\n<td><span class=\"\">20\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"ds-markdown-paragraph\"><em><span class=\"\">Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from\u00a0<\/span><strong><span class=\"\">0.1\u201110\u202f\u00b5M<\/span><\/strong><span class=\"\">.<\/span><\/em><\/p>\n<h2><span class=\"\">Storage &amp; Stability Guidelines<\/span><\/h2>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Storage Condition<\/span><\/th>\n<th><span class=\"\">Shelf Life<\/span><\/th>\n<th><span class=\"\">Notes<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"\">Lyophilised at \u201320\u00b0C, unopened<\/span><\/td>\n<td><span class=\"\">Up to 3 years<\/span><\/td>\n<td><span class=\"\">Use desiccant, protect from light<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Lyophilised at 2\u20118\u00b0C, unopened<\/span><\/td>\n<td><span class=\"\">6\u201112 months<\/span><\/td>\n<td><span class=\"\">\u201320\u00b0C storage is strongly preferred for long\u2011term stability<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Reconstituted at 2\u20118\u00b0C<\/span><\/td>\n<td><span class=\"\">Short\u2011term use<\/span><\/td>\n<td><span class=\"\">Use within days to weeks<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Reconstituted aliquots at \u201320\u00b0C<\/span><\/td>\n<td><span class=\"\">Up to 6 months<\/span><\/td>\n<td><span class=\"\">Single freeze only; discard after thawing<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2><span class=\"\">Why Choose Wuhan Top Miracle Peptides for FOXO4-DRI (10mg)?<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">As an authentic licensed peptide supplier based in the\u00a0<\/span><strong><span class=\"\">United Kingdom<\/span><\/strong><span class=\"\">, we supply\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0and a wide range of research\u2011grade compounds under rigorous quality assurance protocols, fully aligned with Google&#8217;s\u00a0<\/span><strong><span class=\"\">E\u2011E\u2011A\u2011T<\/span><\/strong><span class=\"\">\u00a0standards (Experience, Expertise, Authoritativeness, Trustworthiness).<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Verified Purity:<\/span><\/strong><span class=\"\">\u00a0Independent HPLC analysis with purity guaranteed\u00a0<\/span><strong><span class=\"\">\u226598%<\/span><\/strong><span class=\"\">\u00a0for every batch<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">GMP\u2011Compliant Manufacturing:<\/span><\/strong><span class=\"\">\u00a0All peptides are synthesised under strict quality control conditions.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Full Traceability:<\/span><\/strong><span class=\"\">\u00a0Batch\u2011specific Certificates of Analysis (COA) are available for every order.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Wholesale Supply:<\/span><\/strong><span class=\"\">\u00a0We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">UK\u2011Based Regulatory Compliance:<\/span><\/strong><span class=\"\">\u00a0All products are supplied strictly as research\u2011grade chemicals for laboratory use only (RUO)<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Researchers across the United Kingdom\u2014including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh\u2014trust us for fast domestic delivery, transparent documentation and professional technical support.<\/span><\/p>\n<h2><span class=\"\">FAQ: FOXO4-DRI (10mg) Research Peptide<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What is FOXO4-DRI (10mg) research peptide?<\/span><\/strong><br \/>\n<span class=\"\">FOXO4-DRI is a synthetic, cell\u2011permeable D\u2011retro\u2011inverso (DRI) peptide derived from the forkhead box O4 (FOXO4) transcription factor<\/span><span class=\"\">. It is designed to disrupt the interaction between FOXO4 and p53, selectively inducing apoptosis in senescent cells<\/span><span class=\"\">. Its D\u2011retro\u2011inverso configuration confers enhanced resistance to proteolytic degradation<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">\u00a0What is the sequence and molecular weight of FOXO4-DRI?<\/span><\/strong><br \/>\n<span class=\"\">The sequence is\u00a0<\/span><strong><span class=\"\">D\u2011(LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRPPPRRRQRRKKRG)<\/span><\/strong><span class=\"\">. Its molecular formula is C\u2082\u2082\u2088H\u2083\u2088\u2088N\u2088\u2086O\u2086\u2084, and its molecular weight is approximately\u00a0<\/span><strong><span class=\"\">5358.05 Da<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What are the primary research applications for FOXO4-DRI?<\/span><\/strong><br \/>\n<span class=\"\">FOXO4-DRI is used in cellular senescence and aging research (endothelial cell senescence, vascular aging, testicular aging), fibrosis and scarring research (pulmonary fibrosis, keloids), cartilage and osteoarthritis research (chondrocyte senescence), apoptosis and signal transduction research, and senolytic and anti\u2011senescence research<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">\u00a0What is the mechanism of action of FOXO4-DRI?<\/span><\/strong><br \/>\n<span class=\"\">FOXO4-DRI specifically disrupts the interaction between FOXO4 and p53<\/span><span class=\"\">. In senescent cells, FOXO4 binds p53 in the nucleus, preventing p53\u2011induced apoptosis. FOXO4-DRI displaces FOXO4 from p53, facilitating the nuclear export of phosphorylated p53, which triggers BAX and cleaved caspase\u20113 and activates the p53\/BCL\u20112\/Caspase\u20113 pathway, leading to selective apoptosis of senescent cells<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What purity does your FOXO4-DRI (10mg) meet?<\/span><\/strong><br \/>\n<span class=\"\">Our FOXO4-DRI is tested to\u00a0<\/span><strong><span class=\"\">\u226598% purity<\/span><\/strong><span class=\"\">\u00a0by HPLC<\/span><span class=\"\">. A Certificate of Analysis (COA) is supplied with every order.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">\u00a0How should I reconstitute FOXO4-DRI (10mg)?<\/span><\/strong><br \/>\n<span class=\"\">Reconstitute with sterile bacteriostatic water or sterile PBS (pH\u202f5\u20117). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is\u00a0<\/span><strong><span class=\"\">10\u202fmg\/mL<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">How should I store reconstituted FOXO4-DRI?<\/span><\/strong><br \/>\n<span class=\"\">Reconstituted FOXO4-DRI should be stored at 2\u20118\u00b0C for short\u2011term use. For longer storage, aliquot immediately into single\u2011use vials and store at \u201320\u00b0C for up to 6 months<\/span><span class=\"\">. Avoid repeated freeze\u2011thaw cycles<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Is FOXO4-DRI research peptide legal to purchase in the UK?<\/span><\/strong><br \/>\n<span class=\"\">Yes. FOXO4-DRI is a laboratory reagent sold for\u00a0<\/span><strong><span class=\"\">research use only (RUO)<\/span><\/strong><span class=\"\">. It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in\u2011vitro or in\u2011vivo scientific research, provided it is not marketed with therapeutic claims.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Does Wuhan Top Miracle Peptides ship internationally?<\/span><\/strong><br \/>\n<span class=\"\">Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.<\/span><\/p>\n<h2>Wholesale FOXO4-DRI 10mg Supply Across the UK and Europe<\/h2>\n<p class=\"isSelectedEnd\">Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.<\/p>\n<h3>We Support Enquiries From:<\/h3>\n<ul data-spread=\"false\">\n<li>United Kingdom<\/li>\n<li>France<\/li>\n<li>Germany<\/li>\n<li>Spain<\/li>\n<li>Sweden<\/li>\n<li>Italy<\/li>\n<li>USA<\/li>\n<li>Wider Europe<\/li>\n<\/ul>\n<p class=\"isSelectedEnd\">For larger FOXO4-DRI 10mg enquiries, contact our team before ordering. This helps confirm stock, documentation, shipping options, product identity, and buyer verification requirements.<\/p>\n<h2>Where to Source FOXO4-DRI 10mg in the UK<\/h2>\n<p class=\"isSelectedEnd\">If you are searching for <strong>where to source FOXO4-DRI 10mg in the UK<\/strong>, Wuhan Top Miracle Peptides provides a simple professional enquiry process.<\/p>\n<h3>Professional Enquiry Process<\/h3>\n<ol start=\"1\" data-spread=\"false\">\n<li>Review the FOXO4-DRI 10mg product details.<\/li>\n<li>Check the current label and batch information.<\/li>\n<li>Confirm whether the batch is listed as FOXO4-DRI, FOXO4 DRI, FOXO4-D-Retro-Inverso, or another verified identity.<\/li>\n<li>Ask about COA and purity-related documentation.<\/li>\n<li>Confirm the sequence, chirality, and salt form where required.<\/li>\n<li>Confirm your shipping country.<\/li>\n<li>Discuss wholesale quantity requirements.<\/li>\n<li>Complete buyer verification where required.<\/li>\n<li>Place a professional enquiry with support from our team.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/bulk-orders\/\"><strong>Bulk Peptides Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/shipping-returns\/\"><strong>Shipping &amp; Returns Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/contact-us\/\"><strong>Contact Us Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/shop-3\/\"><strong>Shop Page<\/strong><\/a><br \/>\n<strong>Quality \/ Compliance Page<\/strong><br \/>\n<strong>PubChem \/ compound reference source<\/strong><br \/>\n<strong>Scientific or peer-reviewed reference source<\/strong><br \/>\n<strong>GOV.UK \/ MHRA<\/strong><br \/>\n<strong>Google Search Central<\/strong><br \/>\n<strong>ASA \/ CAP Code Section 12<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">From its discovery as a selective senolytic peptide in a landmark 2017\u00a0<\/span><em><span class=\"\">Cell<\/span><\/em><span class=\"\">\u00a0publication to its well\u2011characterised role in disrupting the FOXO4\u2011p53 interaction and inducing apoptosis in senescent cells,\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0provides a precisely defined and extensively validated platform for advanced senescence and aging research. <\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Its ability to selectively eliminate senescent cells, reduce SASP secretion, and improve tissue function in models of vascular aging, testicular aging, pulmonary fibrosis, and keloid scarring\u2014supported by a growing body of peer\u2011reviewed research published in\u00a0<\/span><em><span class=\"\">Cell<\/span><\/em><span class=\"\">,\u00a0<\/span><em><span class=\"\">Nature Communications<\/span><\/em><span class=\"\">, and other authoritative journals\u2014makes it a valuable addition to any laboratory investigating cellular senescence, the biology of aging, or regenerative medicine. By choosing high\u2011purity, lab\u2011verified\u00a0<\/span><strong><span class=\"\">FOXO4-DRI (10mg) research peptide<\/span><\/strong><span class=\"\">\u00a0from\u00a0<\/span><strong><span class=\"\">Wuhan Top Miracle Peptides<\/span><\/strong><span class=\"\">, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Ready to advance your research with FOXO4-DRI (10mg)?<\/span><\/strong><span class=\"\">\u00a0Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory&#8217;s specific needs.\u00a0<\/span><strong><span class=\"\">Place your order now<\/span><\/strong><span class=\"\">\u00a0and receive GMP\u2011grade FOXO4-DRI delivered directly to your facility in the UK, EU, or USA.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<h1>FOXO4-DRI (10mg)<\/h1>\n<p>Buy FOXO4-DRI 10mg peptide online. High-purity research peptides for sale with shipping to USA, UK, Canada, and Europe.<\/p>\n","protected":false},"featured_media":166,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[19,20,21,22,1136,1150,23,1144,1145,1151,1140,1147,1137,1143,1138,1152,1146,1142,1149,1141,1139,1148,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57],"class_list":["post-874","product","type-product","status-publish","has-post-thumbnail","product_cat-peptides","product_tag-alastin","product_tag-alastinskincare-serum","product_tag-antioxidants","product_tag-bodybuilding","product_tag-buy-foxo4-dri-online-uk","product_tag-cheap-foxo4-dri-uk","product_tag-esthetician","product_tag-foxo4-dri-activates-p53","product_tag-foxo4-dri-apoptosis-results","product_tag-foxo4-dri-before-and-after","product_tag-foxo4-dri-clears-senescent-cells","product_tag-foxo4-dri-dosage","product_tag-foxo4-dri-for-anti-ageing","product_tag-foxo4-dri-for-cancer","product_tag-foxo4-dri-for-longevity","product_tag-foxo4-dri-for-personal-use","product_tag-foxo4-dri-injection-guide","product_tag-foxo4-dri-lifespan-extension","product_tag-foxo4-dri-no-prescription","product_tag-foxo4-dri-reverses-ageing","product_tag-foxo4-dri-senolytic-peptide-results","product_tag-foxo4-dri-treatment-uk","product_tag-ghrp","product_tag-hcgchica","product_tag-hcgcommunity-hcgresults","product_tag-hcgdiet","product_tag-hcgdrop","product_tag-hcgfamily","product_tag-hcginjections-doral","product_tag-hcgjourney","product_tag-hcglife","product_tag-hcgpellets","product_tag-hcgphase","product_tag-hcgplus","product_tag-hcgprotocol","product_tag-hcgsupport","product_tag-hcgusers","product_tag-hcgweightloss","product_tag-hcgworks","product_tag-health","product_tag-hrt","product_tag-hyaluronicacid","product_tag-injectionshcg","product_tag-lipo","product_tag-lipotropic","product_tag-lipotropicinjections","product_tag-miami","product_tag-miamibeach","product_tag-peptideskincare","product_tag-retinol","product_tag-sarms","product_tag-skincareroutine","product_tag-supplements","product_tag-testosterone","product_tag-trihextechnology","product_tag-vitaminc","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product\/874","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/comments?post=874"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/media\/166"}],"wp:attachment":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/media?parent=874"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_brand?post=874"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=874"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}