{"id":884,"date":"2026-05-25T03:49:58","date_gmt":"2026-05-25T03:49:58","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&p=884"},"modified":"2026-06-23T08:25:24","modified_gmt":"2026-06-23T08:25:24","slug":"humanin-10mg","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/humanin-10mg\/","title":{"rendered":"Humanin (10mg)"},"content":{"rendered":"

Humanin (10mg) Research Peptide: A Mitochondrial-Derived Peptide for Neuroprotection & Aging Studies<\/span><\/h1>\n

If your research investigates mitochondrial biology, neuroprotection, or the molecular mechanisms of aging,\u00a0<\/span>Humanin (10mg) research peptide<\/span><\/strong>\u00a0offers a precisely defined and increasingly well-characterised synthetic tool. Humanin is a 24\u2011amino\u2011acid peptide encoded within the mitochondrial genome\u2014the first member of a novel class of mitochondrial-derived peptides discovered in over three decades<\/span>. Initially identified for its ability to protect neurons against Alzheimer’s disease-related neurotoxicity, Humanin has since been shown to exert cytoprotective, anti\u2011apoptotic, and anti\u2011inflammatory effects across a diverse range of disease models, including stroke, cardiovascular disease, and cancer<\/span>. This makes\u00a0<\/span>Humanin (10mg) research peptide<\/span><\/strong>\u00a0a valuable tool for laboratories investigating neurodegeneration, mitochondrial dysfunction, metabolic disorders, and the biology of aging<\/span>.<\/span><\/p>\n

At\u00a0<\/span>Wuhan Top Miracle Peptides<\/span><\/strong>, we supply high\u2011purity\u00a0<\/span>Humanin (10mg) research peptide<\/span><\/strong>\u00a0to research institutions and wholesale buyers across the\u00a0<\/span>United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong>. Every batch is lyophilised, HPLC\u2011verified to \u226598% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into mitochondrial signalling, neuroprotection, and aging begin with uncompromising quality.<\/span><\/p>\n

What Is Humanin and How Does It Work?<\/span><\/h2>\n

To fully appreciate the research potential of\u00a0<\/span>Humanin (10mg) research peptide<\/span><\/strong>, it is essential to understand its unique mitochondrial origin and the mechanisms by which it exerts its pleiotropic effects.<\/span><\/p>\n

The 24\u2011Amino\u2011Acid Mitochondrial Peptide<\/span><\/h3>\n

Humanin is a 24\u2011amino\u2011acid peptide encoded within the mitochondrial 16S ribosomal RNA gene (MT\u2011RNR2)<\/span>. Its sequence is\u00a0<\/span>Met\u2011Ala\u2011Pro\u2011Arg\u2011Gly\u2011Phe\u2011Ser\u2011Cys\u2011Leu\u2011Leu\u2011Leu\u2011Leu\u2011Thr\u2011Ser\u2011Glu\u2011Ile\u2011Asp\u2011Leu\u2011Pro\u2011Val\u2011Lys\u2011Arg\u2011Arg\u2011Ala (MAPRGFSCLLLLTSEIDLPVKRRA)<\/span><\/strong>. The peptide has a molecular formula of\u00a0<\/span>C\u2081\u2081\u2089H\u2082\u2080\u2084N\u2083\u2084O\u2083\u2082S\u2082<\/span><\/strong>\u00a0and a molecular weight of approximately\u00a0<\/span>2687.23 Da<\/span><\/strong>. It has a CAS number of\u00a0<\/span>330936\u201169\u20111<\/span><\/strong>.<\/span><\/p>\n

Humanin is the founding member of a new class of small signalling peptides that originate from the mitochondrial genome\u2014a discovery that challenged the long\u2011held view that human mitochondrial DNA encodes only 13 essential components of the electron transport chain<\/span>. Its expression declines with age, coincident with the increased likelihood for the development of Alzheimer’s disease and other age\u2011related conditions<\/span>.<\/span><\/p>\n

Mechanism of Action: Multi\u2011Target Cytoprotective Signalling<\/span><\/h3>\n

The biological activity of\u00a0<\/span>Humanin (10mg) research peptide<\/span><\/strong>\u00a0is mediated through several intersecting pathways:<\/span><\/p>\n

Anti\u2011Apoptotic Activity via Bax Inhibition<\/span><\/strong><\/p>\n

Humanin’s primary cytoprotective mechanism involves the inhibition of Bax\u2011dependent apoptosis. It binds to Bax and prevents its translocation from the cytosol to the mitochondria, blocking the conformational change from the inactive to active form<\/span>. This action suppresses Bax\u2011dependent apoptosis and has been demonstrated to protect cells from a range of insults, including oxidative stress, serum starvation, and hypoxia<\/span>.<\/span><\/p>\n

Binding to IGFBP\u20113 and Regulation of IGF\u2011I Signalling<\/span><\/strong><\/p>\n

Humanin binds with high affinity to insulin\u2011like growth factor\u2011binding protein 3 (IGFBP\u20113)<\/span>. By binding to IGFBP\u20113, Humanin interferes with its nuclear translocation\u2014a prerequisite for IGFBP\u20113\u2011induced apoptosis\u2014and counteracts IGFBP\u20113\u2011mediated cell death<\/span>. This interaction positions Humanin as a new player in the regulation of the GH\u2011IGF axis<\/span>.<\/span><\/p>\n

Neuroprotection via Trimeric Receptor Signalling<\/span><\/strong><\/p>\n

Humanin protects neurons from the toxic effects of amyloid beta (A\u03b2) by improving hippocampal acetylcholine levels and attenuating oxidative stress and associated neurotoxicity<\/span>. It acts as a ligand for formyl peptide receptor\u2011like 1 (FPRL1) and 2 (FPRL2), and suppresses c\u2011Jun N\u2011terminal kinase (JNK) and ASK\/JNK\u2011mediated neuronal cell death<\/span>.<\/span><\/p>\n

Autophagy Induction and Mitochondrial Protection<\/span><\/strong><\/p>\n

Humanin is an autophagy inducer that promotes cell survival in the presence of metabolic and oxidative stress<\/span>. It restores mitochondrial glutathione levels, increases mitobiogenesis, and preserves mitochondrial function and cell viability under stressful and senescence conditions<\/span>.<\/span><\/p>\n

Key Research Applications for Humanin (10mg)<\/span><\/h2>\n

Humanin (10mg) research peptide<\/span><\/strong>\u00a0is a versatile tool with applications spanning several domains of biomedical research.<\/span><\/p>\n

1. Neurodegenerative Disease & Alzheimer’s Research<\/span><\/h3>\n

The most extensively studied application of Humanin lies in its neuroprotective properties. Research has demonstrated:<\/span><\/p>\n