{"id":918,"date":"2026-05-25T03:50:03","date_gmt":"2026-05-25T03:50:03","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&p=918"},"modified":"2026-06-21T06:59:22","modified_gmt":"2026-06-21T06:59:22","slug":"melanotan-1-10mg","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/melanotan-1-10mg\/","title":{"rendered":"Melanotan 1 (10mg)"},"content":{"rendered":"

Melanotan 1 (10mg) Research Peptide: A Potent MC1R Agonist for Melanogenesis & Photoprotection Studies<\/span><\/h1>\n

If your research investigates melanocortin receptor signalling, melanogenesis pathways, or photoprotection mechanisms,\u00a0<\/span>Melanotan 1 (10mg) research peptide<\/span><\/strong>\u00a0\u2014 also known as afamelanotide \u2014 is a well-characterised synthetic tool worthy of serious consideration. This 13\u2011amino\u2011acid linear peptide is a synthetic analogue of \u03b1\u2011melanocyte\u2011stimulating hormone (\u03b1\u2011MSH), the body’s natural regulator of skin pigmentation<\/span>. Unlike endogenous \u03b1\u2011MSH, which has a very short half\u2011life, Melanotan 1 was engineered with two key substitutions\u2014norleucine at position 4 and D\u2011phenylalanine at position 7\u2014that confer enhanced metabolic stability and receptor binding affinity<\/span>. This makes\u00a0<\/span>Melanotan 1 (10mg) research peptide<\/span><\/strong>\u00a0a valuable tool for laboratories investigating MC1R pharmacology, melanin synthesis, and the molecular mechanisms underlying photoprotection.<\/span><\/p>\n

At\u00a0<\/span>Wuhan Top Miracle Peptides<\/span><\/strong>, we supply high\u2011purity\u00a0<\/span>Melanotan 1 (10mg) research peptide<\/span><\/strong>\u00a0to research institutions and wholesale buyers across the\u00a0<\/span>United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong>. Every batch is lyophilised, HPLC\u2011verified to \u226598% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into melanocortin signalling, melanogenesis, and photoprotection begin with uncompromising quality.<\/span><\/p>\n

What Is Melanotan 1 and How Does It Work?<\/span><\/h2>\n

To fully appreciate the research potential of\u00a0<\/span>Melanotan 1 (10mg) research peptide<\/span><\/strong>, it is essential to understand its biochemical design and the precise mechanism by which it modulates the melanocortin system.<\/span><\/p>\n

The Ac\u2011SYS(Nle)EHFRWGKPV\u2011NH\u2082 Peptide<\/span><\/h3>\n

Melanotan 1 is a synthetic 13\u2011amino\u2011acid peptide with the sequence\u00a0<\/span>Ac\u2011Ser\u2011Tyr\u2011Ser\u2011Nle\u2011Glu\u2011His\u2011D\u2011Phe\u2011Arg\u2011Trp\u2011Gly\u2011Lys\u2011Pro\u2011Val\u2011NH\u2082<\/span><\/strong>. Its molecular formula is\u00a0<\/span>C\u2087\u2088H\u2081\u2081\u2081N\u2082\u2081O\u2081\u2089<\/span><\/strong>, and its molecular weight is approximately\u00a0<\/span>1646.85 g\/mol<\/span><\/strong>. It has a CAS number of\u00a0<\/span>75921\u201169\u20116<\/span><\/strong>.<\/span><\/p>\n

The peptide features two critical modifications that distinguish it from endogenous \u03b1\u2011MSH:<\/span><\/p>\n

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    Norleucine (Nle) substitution at position 4<\/span><\/strong>\u00a0(replacing the oxidation\u2011prone methionine)<\/span><\/p>\n<\/li>\n

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    D\u2011Phenylalanine (D\u2011Phe) substitution at position 7<\/span><\/strong>\u00a0(replacing L\u2011phenylalanine)<\/span><\/p>\n<\/li>\n<\/ul>\n

    These substitutions confer resistance to enzymatic degradation and enhance receptor binding affinity, making Melanotan 1 a more stable and potent research tool than the native hormone<\/span>. The N\u2011terminal acetylation and C\u2011terminal amidation further enhance the peptide’s stability<\/span>.<\/span><\/p>\n

    Mechanism of Action: MC1R Agonism and the Melanogenesis Cascade<\/span><\/h3>\n

    The biological activity of\u00a0<\/span>Melanotan 1 (10mg) research peptide<\/span><\/strong>\u00a0is mediated through its action as a potent agonist at the melanocortin\u20111 receptor (MC1R), a G\u2011protein\u2011coupled receptor predominantly expressed on melanocytes<\/span>.<\/span><\/p>\n

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      High\u2011Affinity Receptor Binding:<\/span><\/strong>\u00a0Melanotan 1 exhibits high binding affinity for MC1R with a Ki of\u00a0<\/span>0.085 nM<\/span><\/strong>. It also binds to MC3, MC4, and MC5 receptors with Ki values of 0.4, 3.8, and 5.1 nM, respectively<\/span>. At the cellular level, it induces cAMP accumulation in cells expressing human MC1R with an EC\u2085\u2080 of\u00a0<\/span>0.5 nM<\/span><\/strong>.<\/span><\/p>\n<\/li>\n

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      G\u2011Protein Activation and cAMP Signalling:<\/span><\/strong>\u00a0Receptor binding activates the associated Gs protein, which stimulates adenylyl cyclase to convert ATP into cyclic AMP (cAMP)<\/span>.<\/span><\/p>\n<\/li>\n

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      PKA Activation and Gene Transcription:<\/span><\/strong>\u00a0Elevated cAMP levels activate Protein Kinase A (PKA), which phosphorylates transcription factors such as CREB<\/span>. This leads to increased expression of the Microphthalmia\u2011associated Transcription Factor (MITF), the master regulator of melanocyte development and function<\/span>.<\/span><\/p>\n<\/li>\n

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      Melanin Synthesis (Melanogenesis):<\/span><\/strong>\u00a0MITF upregulates the expression of key enzymes involved in melanin synthesis, including tyrosinase, TRP\u20111, and TRP\u20112, resulting in the production of eumelanin\u2014the dark, photoprotective form of melanin<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

      Research Relevance: A Clinically Validated Compound<\/span><\/h3>\n

      Understanding Melanotan 1’s clinical and regulatory status is important for any laboratory study. Melanotan 1 (afamelanotide, brand name Scenesse) has received\u00a0<\/span>FDA and EMA approval<\/span><\/strong>\u00a0for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria (EPP), a rare inherited disorder characterised by severe light intolerance<\/span>. In clinical studies, afamelanotide has been shown to prolong pain\u2011free sun exposure, improve quality of life, and reduce the frequency and severity of phototoxic reactions<\/span>.<\/span><\/p>\n

      This regulatory approval provides researchers with well\u2011documented pharmacokinetic and pharmacodynamic data that can inform experimental design.<\/span><\/p>\n

      Key Research Applications for Melanotan 1 (10mg)<\/span><\/h2>\n

      Melanotan 1 (10mg) research peptide<\/span><\/strong>\u00a0is a versatile tool with applications spanning several domains of biomedical research.<\/span><\/p>\n

      1. Melanogenesis and Pigmentation Research<\/span><\/h3>\n

      The most established application of Melanotan 1 lies in its ability to serve as a molecular probe for studying the melanogenesis pathway<\/span>. Research applications include:<\/span><\/p>\n