{"id":925,"date":"2026-05-25T03:50:03","date_gmt":"2026-05-25T03:50:03","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&#038;p=925"},"modified":"2026-06-22T06:04:41","modified_gmt":"2026-06-22T06:04:41","slug":"mots-c","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/mots-c\/","title":{"rendered":"MOTS-C"},"content":{"rendered":"<h1><span class=\"\">MOTS-c Research Peptide: A Mitochondrial-Derived Peptide for Metabolic &amp; Aging Studies<\/span><\/h1>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">If your research investigates mitochondrial biology, metabolic regulation, or the molecular mechanisms of aging,\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0offers a precisely defined and increasingly well-characterised synthetic tool. MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16\u2011amino\u2011acid peptide encoded within the mitochondrial genome<\/span><span class=\"\">. Unlike most proteins, which are encoded by nuclear genes, MOTS-c is produced within mitochondria and acts as a signalling peptide that communicates mitochondrial status to the rest of the cell<\/span><span class=\"\">. It regulates metabolic homeostasis, stress responses, and cell survival, with expression levels declining with age<\/span><span class=\"\">. This makes\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0a valuable tool for laboratories investigating mitochondrial dysfunction, metabolic disorders, and age-related pathologies.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">At\u00a0<\/span><strong><span class=\"\">Wuhan Top Miracle Peptides<\/span><\/strong><span class=\"\">, we supply high\u2011purity\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0to research institutions and wholesale buyers across the\u00a0<\/span><strong><span class=\"\">United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong><span class=\"\">. Every batch is lyophilised, HPLC\u2011verified to \u226598% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into mitochondrial signalling, metabolism, and aging begin with uncompromising quality.<\/span><\/p>\n<h2><span class=\"\">What Is MOTS-c and How Does It Work?<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">To fully appreciate the research potential of\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">, it is essential to understand its unique origin and the precise mechanisms by which it exerts its effects.<\/span><\/p>\n<h3><span class=\"\">The 16\u2011Amino\u2011Acid Mitochondrial Peptide<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">MOTS-c is a synthetic peptide corresponding to the 16\u2011amino\u2011acid sequence encoded within the mitochondrial 12S ribosomal RNA gene<\/span><span class=\"\">. Its sequence is\u00a0<\/span><strong><span class=\"\">H\u2011Met\u2011Arg\u2011Trp\u2011Gln\u2011Glu\u2011Met\u2011Gly\u2011Tyr\u2011Ile\u2011Phe\u2011Tyr\u2011Pro\u2011Arg\u2011Lys\u2011Leu\u2011Arg\u2011OH (MRWQEMGYIFYPRKLR)<\/span><\/strong><span class=\"\">. The peptide has a molecular formula of\u00a0<\/span><strong><span class=\"\">C\u2081\u2080\u2081H\u2081\u2085\u2082N\u2082\u2088O\u2082\u2082S\u2082<\/span><\/strong><span class=\"\">\u00a0and a molecular weight of approximately\u00a0<\/span><strong><span class=\"\">2174.59 Da<\/span><\/strong><span class=\"\">. It has a CAS number of\u00a0<\/span><strong><span class=\"\">1627580-64-6<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The peptide is highly conserved across species and is detectable in various tissues and in circulation<\/span><span class=\"\">. Its expression is regulated by metabolic state, such as fasting, and declines with age<\/span><span class=\"\">.<\/span><\/p>\n<h3><span class=\"\">Mechanism of Action: The Folate\u2011AICAR\u2011AMPK Pathway<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The biological activity of\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0is primarily mediated through the\u00a0<\/span><strong><span class=\"\">Folate\u2011AICAR\u2011AMPK pathway<\/span><\/strong><span class=\"\">:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Folate Cycle Inhibition:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c inhibits the folate cycle at the level of 5\u2011methyltetrahydrofolate (5\u2011MeTHF), leading to the accumulation of the metabolic intermediate\u00a0<\/span><strong><span class=\"\">AICAR<\/span><\/strong><span class=\"\">\u00a0(5\u2011aminoimidazole\u20114\u2011carboxamide ribonucleotide)<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">AMPK Activation:<\/span><\/strong><span class=\"\">\u00a0AICAR is a potent AMP mimetic that activates\u00a0<\/span><strong><span class=\"\">AMP\u2011activated protein kinase (AMPK)<\/span><\/strong><span class=\"\">. This activation promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Metabolic Reprogramming:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c increases cellular NAD+ levels, enhances the expression of GLUT4 (a key glucose transporter), and increases the levels of carnitine shuttle components that transport fatty acids into mitochondria for \u03b2\u2011oxidation<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Nuclear Signalling:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c is significantly expressed in response to stress or exercise and is translocated to the nucleus, where it regulates the expression of stress adaptation\u2011related genes with antioxidant response elements (ARE)<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Research Note: An &#8220;Exercise\u2011Mimetic&#8221; Peptide<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">MOTS\u2011c is considered an &#8220;exercise\u2011mimetic&#8221; because it can improve glucose uptake in skeletal muscle and enhance insulin sensitivity without requiring insulin<\/span><span class=\"\">. In healthy young individuals, a single session of high\u2011intensity interval training can increase muscle MOTS\u2011c levels by up to\u00a0<\/span><strong><span class=\"\">5\u2011fold<\/span><\/strong><span class=\"\">. Conversely, MOTS\u2011c levels in human blood decline with age: levels in the elderly (70\u201181 years) are approximately\u00a0<\/span><strong><span class=\"\">21% lower<\/span><\/strong><span class=\"\">\u00a0than in younger individuals<\/span><span class=\"\">.<\/span><\/p>\n<h2><span class=\"\">Key Research Applications for MOTS\u2011c<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0is a versatile tool with applications spanning several domains of biomedical research.<\/span><\/p>\n<h3><span class=\"\">1. Metabolic Disorders &amp; Insulin Sensitivity Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The most extensively studied application of MOTS\u2011c lies in its role as a metabolic regulator. Research has demonstrated:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Insulin Sensitivity Enhancement:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c treatment in mice prevents age\u2011dependent and high\u2011fat\u2011diet\u2011induced insulin resistance<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Obesity Prevention:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c prevents diet\u2011induced obesity and reduces obesity in mouse models<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Glucose Homeostasis:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c promotes glucose uptake in skeletal muscle and improves systemic glucose regulation<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Clinical Translation:<\/span><\/strong><span class=\"\">\u00a0A Phase 2a clinical trial (MOTS\u2011MET) is currently evaluating whether 12 weeks of MOTS\u2011c treatment improves insulin sensitivity in adults with prediabetes and overweight\/obesity<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">2. Mitochondrial Dysfunction &amp; Bioenergetics Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">MOTS\u2011c is a direct modulator of mitochondrial function, making it a valuable tool for studying mitochondrial biology:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Mitochondrial Biogenesis:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c activates mitochondrial biogenesis through the PGC\u20111\u03b1\/AMPK pathway<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Cardioprotection:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c preserves mitochondrial functional integrity and improves cardiac recovery following ischemia\u2011reperfusion injury in rat models<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Mitochondrial Bioenergetics:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c improves intrinsic muscle mitochondrial bioenergetic health and efficiency<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">3. Aging &amp; Senescence Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">MOTS\u2011c levels decline with age, and its restoration has been shown to reverse age\u2011related metabolic decline:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Pancreatic Islet Cell Senescence:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c treatment reduces pancreatic islet cell senescence and improves glucose intolerance in aged mouse models<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Age\u2011Related Physical Decline:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c is an exercise\u2011induced mitochondrial\u2011encoded regulator of age\u2011dependent physical decline and muscle homeostasis<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Sarcopenia Research:<\/span><\/strong><span class=\"\">\u00a0Higher MOTS\u2011c blood levels in older adults correlate with better muscle function and strength<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">4. Neuroprotection &amp; Neurodegenerative Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Emerging research has explored MOTS\u2011c&#8217;s neuroprotective properties:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Dopaminergic Neurons:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c interacts with Nrf2 to protect dopaminergic neurons against rotenone exposure<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Diabetic Neuropathy:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c treatment improves streptozotocin\u2011induced painful diabetic neuropathy through AMPK\/PGC\u20111\u03b1\u2011mediated mitochondrial biogenesis<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">5. Inflammatory &amp; Osteoarthritis Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">MOTS\u2011c exerts anti\u2011inflammatory and antioxidant effects:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Osteoarthritis:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c attenuates mitochondrial dysfunction, inhibits inflammatory body activation, and rescues chondrocyte pyroptosis in osteoarthritis models<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Cartilage Protection:<\/span><\/strong><span class=\"\">\u00a0MOTS\u2011c regulates the metabolic balance of extracellular matrix (ECM) in cartilage<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"\">Chemical &amp; Physical Specifications<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Accurate characterisation of\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0is essential for reproducible experimental design.<\/span><\/p>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Parameter<\/span><\/th>\n<th><span class=\"\">Specification<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong><span class=\"\">Common Names<\/span><\/strong><\/td>\n<td><span class=\"\">MOTS\u2011c, Mitochondrial ORF of the 12S rRNA Type\u2011c<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Amino Acid Sequence (One\u2011Letter)<\/span><\/strong><\/td>\n<td><span class=\"\">MRWQEMGYIFYPRKLR<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Amino Acid Sequence (Three\u2011Letter)<\/span><\/strong><\/td>\n<td><span class=\"\">H\u2011Met\u2011Arg\u2011Trp\u2011Gln\u2011Glu\u2011Met\u2011Gly\u2011Tyr\u2011Ile\u2011Phe\u2011Tyr\u2011Pro\u2011Arg\u2011Lys\u2011Leu\u2011Arg\u2011OH<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Molecular Formula<\/span><\/strong><\/td>\n<td><span class=\"\">C\u2081\u2080\u2081H\u2081\u2085\u2082N\u2082\u2088O\u2082\u2082S\u2082<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Molecular Weight<\/span><\/strong><\/td>\n<td><span class=\"\">~2174.59 Da<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">CAS Number<\/span><\/strong><\/td>\n<td><span class=\"\">1627580\u201164\u20116<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Purity<\/span><\/strong><\/td>\n<td><strong><span class=\"\">\u226598%<\/span><\/strong><span class=\"\">\u00a0(HPLC verified)<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Appearance<\/span><\/strong><\/td>\n<td><span class=\"\">White to off\u2011white lyophilised powder<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Solubility<\/span><\/strong><\/td>\n<td><span class=\"\">Soluble in sterile water and sterile PBS (pH 5\u20117)<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Storage (Lyophilised)<\/span><\/strong><\/td>\n<td><span class=\"\">\u201320\u00b0C, sealed, protected from light; stable for up to 2 years<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Storage (Reconstituted)<\/span><\/strong><\/td>\n<td><span class=\"\">2\u20118\u00b0C for short\u2011term use; single\u2011use aliquots at \u201320\u00b0C for long\u2011term storage<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<blockquote>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Note:<\/span><\/strong><span class=\"\">\u00a0The peptide is typically supplied as a TFA or acetate salt, which enhances aqueous solubility<\/span><span class=\"\">. The acetate salt form has a molecular formula of C\u2081\u2080\u2083H\u2081\u2085\u2086N\u2082\u2088O\u2082\u2084S\u2082 and a molecular weight of approximately 2234.64 Da<\/span><span class=\"\">.<\/span><\/p>\n<\/blockquote>\n<h2><span class=\"\">Reconstitution &amp; Handling Protocol for MOTS\u2011c<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Proper reconstitution of\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0is critical for maintaining its structural integrity and biological activity.<\/span><\/p>\n<h3><span class=\"\">Step 1 \u2013 Preparation<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Bring the sealed MOTS\u2011c vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH\u202f5\u20117) to room temperature.\u00a0<\/span><em><span class=\"\">Condensation can degrade the lyophilised powder.<\/span><\/em><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 2 \u2013 Vial Sanitisation<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Wipe the rubber stopper of the MOTS\u2011c vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 3 \u2013 Reconstitution<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is\u00a0<\/span><strong><span class=\"\">1\u20112 mg per 1 mL of diluent<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Insert the needle and slowly inject the diluent\u00a0<\/span><strong><span class=\"\">against the inner glass wall<\/span><\/strong><span class=\"\">. Do not spray directly onto the lyophilised powder.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Gently swirl the vial until the solution is clear and fully dissolved.\u00a0<\/span><strong><span class=\"\">Do not shake vigorously<\/span><\/strong><span class=\"\">, as shaking can cause denaturation.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 4 \u2013 Aliquoting &amp; Storage<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Immediately after dissolution, aliquot the reconstituted MOTS\u2011c into single\u2011use sterile vials.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Store aliquots at \u201320\u00b0C.\u00a0<\/span><strong><span class=\"\">Avoid repeated freeze\u2011thaw cycles<\/span><\/strong><span class=\"\">, as peptides are susceptible to degradation.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Once thawed, store at 2\u20118\u00b0C and use within a short period.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Concentration Reference Table<\/span><\/h3>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Vial Mass<\/span><\/th>\n<th><span class=\"\">Diluent Volume<\/span><\/th>\n<th><span class=\"\">Final Concentration<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"\">1\u202fmg<\/span><\/td>\n<td><span class=\"\">1.0\u202fmL<\/span><\/td>\n<td><span class=\"\">1\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">2\u202fmg<\/span><\/td>\n<td><span class=\"\">1.0\u202fmL<\/span><\/td>\n<td><span class=\"\">2\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">5\u202fmg<\/span><\/td>\n<td><span class=\"\">2.5\u202fmL<\/span><\/td>\n<td><span class=\"\">2\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"ds-markdown-paragraph\"><em><span class=\"\">Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations range from\u00a0<\/span><strong><span class=\"\">10\u2011100\u202f\u00b5M<\/span><\/strong><span class=\"\">.<\/span><\/em><\/p>\n<h2><span class=\"\">Storage &amp; Stability Guidelines<\/span><\/h2>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Storage Condition<\/span><\/th>\n<th><span class=\"\">Shelf Life<\/span><\/th>\n<th><span class=\"\">Notes<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"\">Lyophilised at \u201320\u00b0C, unopened<\/span><\/td>\n<td><span class=\"\">2 years<\/span><\/td>\n<td><span class=\"\">Use desiccant, protect from light<\/span><span class=\"\">.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Lyophilised at 2\u20118\u00b0C, unopened<\/span><\/td>\n<td><span class=\"\">6\u201112 months<\/span><\/td>\n<td><span class=\"\">\u201320\u00b0C storage is strongly preferred for long\u2011term stability.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Reconstituted at 2\u20118\u00b0C<\/span><\/td>\n<td><span class=\"\">Short\u2011term use<\/span><\/td>\n<td><span class=\"\">Use within days to weeks.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Reconstituted aliquots at \u201320\u00b0C<\/span><\/td>\n<td><span class=\"\">Up to 3 months<\/span><\/td>\n<td><span class=\"\">Single freeze only; discard after thawing.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2><span class=\"\">Why Choose Wuhan Top Miracle Peptides for MOTS\u2011c?<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">As an authentic licensed peptide supplier based in the\u00a0<\/span><strong><span class=\"\">United Kingdom<\/span><\/strong><span class=\"\">, we supply\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0and a wide range of research\u2011grade compounds under rigorous quality assurance protocols, fully aligned with Google&#8217;s\u00a0<\/span><strong><span class=\"\">E\u2011E\u2011A\u2011T<\/span><\/strong><span class=\"\">\u00a0standards (Experience, Expertise, Authoritativeness, Trustworthiness).<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Verified Purity:<\/span><\/strong><span class=\"\">\u00a0Independent HPLC analysis with purity guaranteed\u00a0<\/span><strong><span class=\"\">\u226598%<\/span><\/strong><span class=\"\">\u00a0for every batch<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">GMP\u2011Compliant Manufacturing:<\/span><\/strong><span class=\"\">\u00a0All peptides are synthesised in ISO\u202f13485:2016 and GMP\u2011certified facilities, ensuring batch\u2011to\u2011batch consistency.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Full Traceability:<\/span><\/strong><span class=\"\">\u00a0Batch\u2011specific Certificates of Analysis (COA) are available for every order.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Wholesale Supply:<\/span><\/strong><span class=\"\">\u00a0We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">UK\u2011Based Regulatory Compliance:<\/span><\/strong><span class=\"\">\u00a0All products are supplied strictly as research\u2011grade chemicals for laboratory use only (RUO).<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Researchers across the United Kingdom\u2014including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh\u2014trust us for fast domestic delivery, transparent documentation and professional technical support.<\/span><\/p>\n<h2><span class=\"\">FAQ: MOTS\u2011c Research Peptide<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What is MOTS\u2011c research peptide?<\/span><\/strong><br \/>\n<span class=\"\">MOTS\u2011c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16\u2011amino\u2011acid peptide encoded within the mitochondrial genome. It acts as a mitochondrial\u2011derived signalling peptide that regulates metabolic homeostasis, stress responses, and cell survival through the Folate\u2011AICAR\u2011AMPK pathway<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">\u00a0What is the sequence and molecular weight of MOTS\u2011c?<\/span><\/strong><br \/>\n<span class=\"\">The sequence is\u00a0<\/span><strong><span class=\"\">H\u2011Met\u2011Arg\u2011Trp\u2011Gln\u2011Glu\u2011Met\u2011Gly\u2011Tyr\u2011Ile\u2011Phe\u2011Tyr\u2011Pro\u2011Arg\u2011Lys\u2011Leu\u2011Arg\u2011OH (MRWQEMGYIFYPRKLR)<\/span><\/strong><span class=\"\">. Its molecular weight is approximately\u00a0<\/span><strong><span class=\"\">2174.59 Da<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What are the primary research applications for MOTS\u2011c?<\/span><\/strong><br \/>\n<span class=\"\">MOTS\u2011c is used in metabolic disorders and insulin sensitivity research, mitochondrial dysfunction and bioenergetics studies, aging and senescence research, neuroprotection and neurodegenerative research, and inflammatory and osteoarthritis research<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What is the mechanism of action of MOTS\u2011c?<\/span><\/strong><br \/>\n<span class=\"\">MOTS\u2011c inhibits the folate cycle, leading to AICAR accumulation, which activates AMPK. This promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis<\/span><span class=\"\">. MOTS\u2011c also translocates to the nucleus to regulate stress adaptation genes<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What purity does your MOTS\u2011c research peptide meet?<\/span><\/strong><br \/>\n<span class=\"\">Our MOTS\u2011c is tested to\u00a0<\/span><strong><span class=\"\">\u226598% purity<\/span><\/strong><span class=\"\">\u00a0by HPLC. A Certificate of Analysis (COA) is supplied with every order<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">How should I reconstitute MOTS\u2011c?<\/span><\/strong><br \/>\n<span class=\"\">Reconstitute with sterile bacteriostatic water or sterile PBS (pH\u202f5\u20117). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">How should I store reconstituted MOTS\u2011c?<\/span><\/strong><br \/>\n<span class=\"\">Reconstituted MOTS\u2011c should be stored at 2\u20118\u00b0C for short\u2011term use. For longer storage, aliquot immediately into single\u2011use vials and store at \u201320\u00b0C for up to 3 months. Avoid repeated freeze\u2011thaw cycles.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Is MOTS\u2011c research peptide legal to purchase in the UK?<\/span><\/strong><br \/>\n<span class=\"\">Yes. MOTS\u2011c is a laboratory reagent sold for\u00a0<\/span><strong><span class=\"\">research use only (RUO)<\/span><\/strong><span class=\"\">. It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in\u2011vitro or in\u2011vivo scientific research, provided it is not marketed with therapeutic claims.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Does Wuhan Top Miracle Peptides ship internationally?<\/span><\/strong><br \/>\n<span class=\"\">Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.<\/span><\/p>\n<h2>Wholesale MOTS-C Supply Across the UK and Europe<\/h2>\n<p class=\"isSelectedEnd\">Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.<\/p>\n<h3>We Support Enquiries From:<\/h3>\n<ul data-spread=\"false\">\n<li>United Kingdom<\/li>\n<li>France<\/li>\n<li>Germany<\/li>\n<li>Spain<\/li>\n<li>Sweden<\/li>\n<li>Italy<\/li>\n<li>USA<\/li>\n<li>Wider Europe<\/li>\n<\/ul>\n<p class=\"isSelectedEnd\">For larger MOTS-C enquiries, contact our team before ordering. This helps confirm stock, documentation, shipping options, and buyer verification requirements.<\/p>\n<h2>Where to Source MOTS-C Peptide in the UK<\/h2>\n<p class=\"isSelectedEnd\">If you are searching for <strong>where to source MOTS-C peptide in the UK<\/strong>, Wuhan Top Miracle Peptides provides a simple professional enquiry process.<\/p>\n<h3>Professional Enquiry Process<\/h3>\n<ol start=\"1\" data-spread=\"false\">\n<li>Review the MOTS-C product details.<\/li>\n<li>Check the current label and batch information.<\/li>\n<li>Confirm whether the batch is listed as MOTS-C, MOTS-c, mitochondrial-derived peptide, or another verified identity.<\/li>\n<li>Ask about COA and purity-related documentation.<\/li>\n<li>Confirm your shipping country.<\/li>\n<li>Discuss wholesale quantity requirements.<\/li>\n<li>Complete buyer verification where required.<\/li>\n<li>Place a professional enquiry with support from our team.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/bulk-orders\/\"><strong>Bulk Peptides Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/shipping-returns\/\"><strong>Shipping &amp; Returns Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/contact-us\/\"><strong>Contact Us Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/shop-3\/\"><strong>Shop Page<\/strong><\/a><br \/>\n<strong>Quality \/ Compliance Page<\/strong><br \/>\n<strong>PubChem \/ NCBI reference information<\/strong><br \/>\n<strong>Peer-reviewed research reference<\/strong><br \/>\n<strong>GOV.UK \/ MHRA<\/strong><br \/>\n<strong>Google Search Central<\/strong><br \/>\n<strong>ASA \/ CAP Code Section 12<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">From its discovery as a mitochondrial\u2011encoded signalling peptide to its well\u2011characterised role in the Folate\u2011AICAR\u2011AMPK pathway,\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0provides a precisely defined platform for advanced mitochondrial and metabolic research. Its ability to regulate glucose homeostasis, enhance insulin sensitivity, promote mitochondrial biogenesis, and modulate aging\u2011related pathways\u2014supported by peer\u2011reviewed studies published in\u00a0<\/span><em><span class=\"\">Cell Metabolism<\/span><\/em><span class=\"\">,\u00a0<\/span><em><span class=\"\">Nature<\/span><\/em><span class=\"\">,\u00a0<\/span><em><span class=\"\">Experimental &amp; Molecular Medicine<\/span><\/em><span class=\"\">, and the\u00a0<\/span><em><span class=\"\">Journal of Translational Medicine<\/span><\/em><span class=\"\">\u2014makes it a valuable addition to any laboratory investigating mitochondrial dysfunction, metabolic disorders, or the biology of aging. By choosing high\u2011purity, lab\u2011verified\u00a0<\/span><strong><span class=\"\">MOTS-c research peptide<\/span><\/strong><span class=\"\">\u00a0from\u00a0<\/span><strong><span class=\"\">Wuhan Top Miracle Peptides<\/span><\/strong><span class=\"\">, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Ready to advance your research with MOTS\u2011c?<\/span><\/strong><span class=\"\">\u00a0Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory&#8217;s specific needs.\u00a0<\/span><strong><span class=\"\">Place your order now<\/span><\/strong><span class=\"\">\u00a0and receive GMP\u2011grade MOTS\u2011c delivered directly to your facility in the UK, EU, or USA.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Buy MOTS-C (10mg) USA. Authentic, lab-tested peptides shipped across US, Canada, UK &amp; Europe. Wholesale discounts available.<\/p>\n","protected":false},"featured_media":235,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[832,846,268,395,854,855,853,847,843,839,841,840,834,836,838,835,837,848,833,842,845,850,851,852,844,849,857,232,212,637,266,215,856,269,218,239],"class_list":["post-925","product","type-product","status-publish","has-post-thumbnail","product_cat-peptides","product_tag-buy-mots-c-online-uk","product_tag-cheap-mots-c-uk","product_tag-coa-peptide-supplier-uk","product_tag-europe-peptide-supplier","product_tag-mitochondrial-peptide-uk","product_tag-mitochondrial-derived-peptide-uk","product_tag-mots-c-batch-documentation","product_tag-mots-c-before-and-after","product_tag-mots-c-dosage","product_tag-mots-c-for-anti-ageing","product_tag-mots-c-for-energy","product_tag-mots-c-for-exercise-performance","product_tag-mots-c-for-fat-loss","product_tag-mots-c-for-insulin-sensitivity","product_tag-mots-c-for-longevity","product_tag-mots-c-for-metabolism","product_tag-mots-c-for-mitochondrial-health","product_tag-mots-c-for-personal-use","product_tag-mots-c-for-weight-loss","product_tag-mots-c-injection-guide","product_tag-mots-c-no-prescription","product_tag-mots-c-peptide","product_tag-mots-c-research-peptide","product_tag-mots-c-supplier-uk","product_tag-mots-c-treatment-uk","product_tag-mots-c-uk","product_tag-peptide-documentation-uk","product_tag-peptide-purity-uk","product_tag-peptides-for-sale-uk","product_tag-professional-peptide-enquiry-uk","product_tag-professional-peptide-supplier-uk","product_tag-research-peptides-europe","product_tag-research-grade-mots-c","product_tag-uk-peptide-supplier","product_tag-where-to-buy-peptides-in-uk","product_tag-wholesale-peptides-uk","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product\/925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/comments?post=925"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/media\/235"}],"wp:attachment":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/media?parent=925"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_brand?post=925"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=925"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}