{"id":927,"date":"2026-05-25T03:50:03","date_gmt":"2026-05-25T03:50:03","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&p=927"},"modified":"2026-06-22T20:17:46","modified_gmt":"2026-06-22T20:17:46","slug":"n-acetyl-semax-25mg","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/n-acetyl-semax-25mg\/","title":{"rendered":"N-Acetyl Semax (25mg)"},"content":{"rendered":"

N-Acetyl Semax (25mg) Research Peptide: A Stabilised Heptapeptide for Neuroprotection & Cognitive Studies<\/span><\/h1>\n

If your research investigates neuroprotection, cognitive enhancement, or the neurochemical pathways underlying brain resilience,\u00a0<\/span>N-Acetyl Semax (25mg) research peptide<\/span><\/strong>\u00a0offers a precisely defined and increasingly well-characterised synthetic tool. N-Acetyl Semax is the acetylated analogue of the synthetic heptapeptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro), which itself was developed as a stable analog of the adrenocorticotropic hormone fragment ACTH(4-10)<\/span>. By capping the N-terminus with an acetyl group, this structural modification is thought to enhance the peptide’s metabolic stability and resistance to enzymatic degradation<\/span>. This makes\u00a0<\/span>N-Acetyl Semax (25mg) research peptide<\/span><\/strong>\u00a0a valuable tool for laboratories investigating neurotrophic signalling, neurotransmitter regulation, and stress resilience.<\/span><\/p>\n

At\u00a0<\/span>Wuhan Top Miracle Peptides<\/span><\/strong>, we supply high\u2011purity\u00a0<\/span>N-Acetyl Semax (25mg) research peptide<\/span><\/strong>\u00a0to research institutions and wholesale buyers across the\u00a0<\/span>United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong>. Every batch is lyophilised, HPLC\u2011verified to \u226598% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into neurochemistry, cognition, and neuroprotection begin with uncompromising quality.<\/span><\/p>\n

What Is N-Acetyl Semax and How Does It Work?<\/span><\/h2>\n

To fully appreciate the research potential of\u00a0<\/span>N-Acetyl Semax (25mg) research peptide<\/span><\/strong>, it is essential to understand its biochemical design and the mechanisms by which it exerts its neuroactive effects.<\/span><\/p>\n

The Acetylated Heptapeptide<\/span><\/h3>\n

N-Acetyl Semax is a synthetic acetylated heptapeptide with the sequence\u00a0<\/span>Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH\u2082<\/span><\/strong>. Its molecular formula is\u00a0<\/span>C\u2083\u2089H\u2085\u2084N\u2081\u2080O\u2081\u2080S<\/span><\/strong>, with a molecular weight of approximately\u00a0<\/span>854.97 g\/mol<\/span><\/strong>. It has a CAS number of\u00a0<\/span>2920938-90-3<\/span><\/strong>.<\/span><\/p>\n

The peptide encompasses the sequence 4-7 of the N-terminal domain of adrenocorticotropic hormone (ACTH) combined with a C-terminal Pro-Gly-Pro tripeptide<\/span>. The N-terminal acetylation is a key structural feature that enhances the peptide’s stability and resistance to enzymatic degradation<\/span>.<\/span><\/p>\n

Mechanism of Action: Neurotrophic and Neuromodulatory Pathways<\/span><\/h3>\n

The biological activity of\u00a0<\/span>N-Acetyl Semax (25mg) research peptide<\/span><\/strong>\u00a0is hypothesised to involve several intersecting pathways:<\/span><\/p>\n

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    Neurotrophic Factor Support:<\/span><\/strong>\u00a0Investigations suggest that N-Acetyl Semax may influence the expression of neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF)<\/span>. BDNF plays a critical role in supporting neuronal survival, differentiation, and synaptic plasticity, which are essential for learning and memory processes<\/span>.<\/span><\/p>\n<\/li>\n

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    Neurotransmitter Modulation:<\/span><\/strong>\u00a0The peptide is thought to interact with enkephalin, serotonin, and dopamine signalling pathways<\/span>. It may also impact the regulation of glutamate, a key excitatory neurotransmitter, potentially reducing excitotoxic risks and supporting neuronal function in research models<\/span>.<\/span><\/p>\n<\/li>\n

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    Melanocortin Receptor Interaction:<\/span><\/strong>\u00a0As a synthetic peptide derivative belonging to the melanocortin family, N-Acetyl Semax is hypothesised to interact with melanocortin receptors\u2014a family of G-protein-coupled receptors implicated in cognitive function, stress responses, and metabolic regulation<\/span>.<\/span><\/p>\n<\/li>\n

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    Copper Coordination and Metal Ion Homeostasis:<\/span><\/strong>\u00a0Research has shown that N-terminal acetylation modulates the ability of Semax to form complex species with Cu(II) ions<\/span>. At physiological pH, the main complex species formed by Ac-Semax consists of a distorted CuN\u2083O chromophore<\/span>. Studies indicate that acetylation abolished the protective activity from copper toxicity in a neuroblastoma cell line, demonstrating the crucial role played by the free NH\u2082 terminus in cell protection<\/span>. Acetylation did not affect Zn(II) influx in neuroblastoma cells<\/span>.<\/span><\/p>\n<\/li>\n

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    HPA Axis Modulation:<\/span><\/strong>\u00a0The peptide may influence the hypothalamic-pituitary-adrenal (HPA) axis, a critical component of the stress response system, potentially impacting resilience to stress and maintaining homeostasis in neuroendocrine systems<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

    N-Acetyl Semax vs. Semax: The Role of Acetylation<\/span><\/h3>\n

    The primary distinction between N-Acetyl Semax and its parent peptide Semax lies in the N-terminal acetylation. This modification delivers enhanced stability, making the N-terminus of the peptide resistant to degradation by leucine aminopeptidase<\/span>. The peptide is more resistant to proteolysis in blood plasma enzymes following N-terminal acetylation, and it withstands degradation\u00a0<\/span>30 minutes longer<\/span><\/strong>\u00a0than unmodified Semax<\/span>. Researchers report increased stability in brain tissue following N-terminal acetylation, potentially indicating prolonged effects compared to Semax<\/span>. Amidation at the C-terminus further protects the peptide from hydrolysis<\/span>.<\/span><\/p>\n

    Key Research Applications for N-Acetyl Semax (25mg)<\/span><\/h2>\n

    N-Acetyl Semax (25mg) research peptide<\/span><\/strong>\u00a0is a versatile tool with applications spanning several domains of biomedical research.<\/span><\/p>\n

    1. Cognitive Enhancement & Memory Research<\/span><\/h3>\n

    N-Acetyl Semax is studied for its potential to enhance memory, learning, and cognitive performance. Research applications include:<\/span><\/p>\n