{"id":929,"date":"2026-05-25T03:50:06","date_gmt":"2026-05-25T03:50:06","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&#038;p=929"},"modified":"2026-06-18T15:19:03","modified_gmt":"2026-06-18T15:19:03","slug":"nonapeptide-1-200mg","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/nonapeptide-1-200mg\/","title":{"rendered":"Nonapeptide-1 (200mg)"},"content":{"rendered":"<h1><span class=\"\">Nonapeptide-1 (200mg) Research Peptide: An MC1R Antagonist for Melanogenesis &amp; Receptor Studies<\/span><\/h1>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">If your research investigates melanocortin receptor signalling, melanogenesis pathways, or the regulation of pigmentation at the molecular level,\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0offers a precisely defined synthetic tool. Also known as Melanostatine-5, this nine\u2011amino\u2011acid peptide is a potent and selective antagonist of the melanocortin\u20111 receptor (MC1R). By competitively blocking the binding of \u03b1\u2011melanocyte\u2011stimulating hormone (\u03b1\u2011MSH) to MC1R, Nonapeptide\u20111 effectively inhibits the downstream signalling cascade that drives melanin synthesis. This makes it a valuable research tool for laboratories investigating skin pigmentation, adrenal steroidogenesis, and the molecular mechanisms of melanocortin receptor pharmacology<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">At\u00a0<\/span><strong><span class=\"\">Wuhan Top Miracle Peptides<\/span><\/strong><span class=\"\">, we supply high\u2011purity\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0to research institutions and wholesale buyers across the\u00a0<\/span><strong><span class=\"\">United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong><span class=\"\">. Every batch is lyophilised, HPLC\u2011verified to \u226598% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into melanogenesis, MC1R signalling, and pigmentation research begin with uncompromising quality.<\/span><\/p>\n<h2><span class=\"\">What Is Nonapeptide\u20111 and How Does It Work?<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">To fully appreciate the research potential of\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">, it is essential to understand its biochemical design and the precise mechanism by which it modulates melanocortin receptor signalling.<\/span><\/p>\n<h3><span class=\"\">The Nine\u2011Amino\u2011Acid Peptide<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Nonapeptide\u20111 is a synthetic linear peptide consisting of nine amino acids with the sequence\u00a0<\/span><strong><span class=\"\">Met\u2011Pro\u2011D\u2011Phe\u2011Arg\u2011D\u2011Trp\u2011Phe\u2011Lys\u2011Pro\u2011Val\u2011NH\u2082<\/span><\/strong><span class=\"\">. Its molecular formula is\u00a0<\/span><strong><span class=\"\">C\u2086\u2081H\u2088\u2087N\u2081\u2085O\u2089S<\/span><\/strong><span class=\"\">, and its molecular weight is approximately\u00a0<\/span><strong><span class=\"\">1206.5 g\/mol<\/span><\/strong><span class=\"\">. It has a CAS number of\u00a0<\/span><strong><span class=\"\">158563\u201145\u20112<\/span><\/strong><span class=\"\">. The presence of D\u2011amino acids (D\u2011Phe and D\u2011Trp) in the sequence enhances the peptide&#8217;s stability and resistance to enzymatic degradation.<\/span><\/p>\n<h3><span class=\"\">Mechanism of Action: Competitive Antagonism at MC1R<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The biological activity of\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0is rooted in its ability to act as a competitive antagonist at the melanocortin\u20111 receptor (MC1R):<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">MC1R Selectivity:<\/span><\/strong><span class=\"\">\u00a0Nonapeptide\u20111 is a selective MC1R antagonist with a binding affinity of\u00a0<\/span><strong><span class=\"\">Ki = 40 nM<\/span><\/strong><span class=\"\">. It binds to the MC1 receptor on melanocytes with high specificity, effectively blocking the receptor site<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Inhibition of \u03b1\u2011MSH Signalling:<\/span><\/strong><span class=\"\">\u00a0By competitively binding to MC1R, it prevents \u03b1\u2011melanocyte\u2011stimulating hormone (\u03b1\u2011MSH) from activating the receptor. This blocks the subsequent increase in intracellular cyclic AMP (cAMP), which is the primary second messenger in the melanogenesis cascade<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Downregulation of Melanogenic Enzymes:<\/span><\/strong><span class=\"\">\u00a0The inhibition of MC1R signalling leads to a downregulation of key melanogenic regulators, including\u00a0<\/span><strong><span class=\"\">tyrosinase, TRP\u20111, TRP\u20112, and MITF<\/span><\/strong><span class=\"\">\u00a0(microphthalmia\u2011associated transcription factor)<\/span><span class=\"\">. This further suppresses melanin production at the transcriptional level.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Inhibition of Melanosome Dispersion:<\/span><\/strong><span class=\"\">\u00a0Nonapeptide\u20111 effectively inhibits \u03b1\u2011MSH\u2011induced melanosome dispersion in melanocytes, a critical step in the pigmentation process<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Research Potency<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The peptide has demonstrated potent inhibitory activity in vitro, with an IC\u2085\u2080 of\u00a0<\/span><strong><span class=\"\">2.5 nM<\/span><\/strong><span class=\"\">\u00a0for inhibiting intracellular cAMP elevation and\u00a0<\/span><strong><span class=\"\">11 nM<\/span><\/strong><span class=\"\">\u00a0for inhibiting melanosome dispersion induced by \u03b1\u2011MSH<\/span><span class=\"\">. These low nanomolar concentrations highlight its high potency as a research tool.<\/span><\/p>\n<h2><span class=\"\">Key Research Applications for Nonapeptide\u20111 (200mg)<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0is a versatile tool with applications spanning several areas of dermatological and receptor research.<\/span><\/p>\n<h3><span class=\"\">1. Melanogenesis &amp; Pigmentation Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The most established application of Nonapeptide\u20111 lies in its ability to serve as a molecular probe for studying the melanogenesis pathway. Its mechanism as an MC1R antagonist makes it a valuable tool for:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Investigating the \u03b1\u2011MSH\u2011MC1R\u2011cAMP signalling cascade in melanocytes<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Studying the regulation of melanogenic enzymes (tyrosinase, TRP\u20111, TRP\u20112) and the transcription factor MITF<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Exploring the molecular mechanisms underlying hyperpigmentation disorders such as melasma and age spots<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Developing and validating in vitro models for screening potential melanogenesis inhibitors<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Research suggests that Nonapeptide\u20111 may reduce melanin synthesis by approximately one\u2011third in research systems<\/span><span class=\"\">.<\/span><\/p>\n<h3><span class=\"\">2. MC1R Receptor Pharmacology &amp; Signalling Studies<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">As a selective MC1R antagonist, Nonapeptide\u20111 is a valuable tool for:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Dissecting the structural and functional properties of the melanocortin\u20111 receptor<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Studying the kinetics of receptor\u2011ligand interactions and competitive binding<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Exploring the role of MC1R in melanocyte biology and pigmentation<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Investigating the downstream signalling pathways activated by MC1R<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Nonapeptide\u20111&#8217;s high selectivity (Ki = 40 nM) and potency make it an ideal reference standard for benchmarking novel MC1R\u2011targeted compounds<\/span><span class=\"\">.<\/span><\/p>\n<h3><span class=\"\">3. Adrenal Steroidogenesis Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Beyond its role in pigmentation, Nonapeptide\u20111 has been studied for its effects on steroid production in the adrenal gland<\/span><span class=\"\">. The peptide can be used to investigate:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The role of MC1R and related melanocortin receptors in adrenal function<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The regulation of steroidogenesis and its modulation by peptide antagonists<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The interplay between melanocortin receptor signalling and adrenal hormone production<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">4. Skin Cancer Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Nonapeptide\u20111 has been explored in the context of skin cancer research<\/span><span class=\"\">. Research applications include:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Investigating the role of MC1R signalling in melanoma biology<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Studying the effects of MC1R antagonism on melanocyte proliferation and transformation<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Exploring potential pathways for modulating pigmentation\u2011related skin conditions<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">5. Formulation &amp; Nanotechnology Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Nonapeptide\u20111 has been investigated in advanced delivery systems. For example, a study explored\u00a0<\/span><strong><span class=\"\">Nonapeptide\u20111\u2011conjugated mesoporous silica nanoparticles<\/span><\/strong><span class=\"\">\u00a0(EGCG@NP\u2011MSN) to improve the stability and bioavailability of EGCG for reversing skin photoaging<\/span><span class=\"\">. This positions the peptide as a valuable tool for:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Studying peptide\u2011based targeting and delivery systems<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Investigating the stability and formulation of bioactive peptides<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Developing novel nanoparticle platforms for dermatological research<\/span><\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"\">Chemical &amp; Physical Specifications for Nonapeptide-1 (200mg)<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Accurate characterisation of\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0is essential for reproducible experimental design.<\/span><\/p>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Parameter<\/span><\/th>\n<th><span class=\"\">Specification<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong><span class=\"\">Common Names<\/span><\/strong><\/td>\n<td><span class=\"\">Nonapeptide\u20111, Melanostatine\u20115, Melanostatin\u20115<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Amino Acid Sequence<\/span><\/strong><\/td>\n<td><span class=\"\">Met\u2011Pro\u2011D\u2011Phe\u2011Arg\u2011D\u2011Trp\u2011Phe\u2011Lys\u2011Pro\u2011Val\u2011NH\u2082<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Molecular Formula<\/span><\/strong><\/td>\n<td><span class=\"\">C\u2086\u2081H\u2088\u2087N\u2081\u2085O\u2089S<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Molecular Weight<\/span><\/strong><\/td>\n<td><span class=\"\">~1206.5 g\/mol<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">CAS Number<\/span><\/strong><\/td>\n<td><span class=\"\">158563\u201145\u20112<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Purity<\/span><\/strong><\/td>\n<td><strong><span class=\"\">\u226598%<\/span><\/strong><span class=\"\">\u00a0(HPLC verified)<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Appearance<\/span><\/strong><\/td>\n<td><span class=\"\">White to off\u2011white lyophilised powder<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Solubility<\/span><\/strong><\/td>\n<td><span class=\"\">Soluble in water (\u226550 mg\/mL as acetate salt)<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Stable pH Range<\/span><\/strong><\/td>\n<td><span class=\"\">4\u20117<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Storage (Lyophilised)<\/span><\/strong><\/td>\n<td><span class=\"\">\u201320\u00b0C, sealed, protected from light; stable for up to 2 years<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Storage (Reconstituted)<\/span><\/strong><\/td>\n<td><span class=\"\">2\u20118\u00b0C for up to 28 days; single\u2011use aliquots at \u201320\u00b0C for up to 3 months<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<blockquote>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Note:<\/span><\/strong><span class=\"\">\u00a0The 200\u202fmg mass refers to the weight of the peptide in its lyophilised form. Nonapeptide\u20111 is typically supplied as an acetate salt, which significantly enhances its aqueous solubility (\u226550 mg\/mL in water)<\/span><span class=\"\">.<\/span><\/p>\n<\/blockquote>\n<h2><span class=\"\">Reconstitution &amp; Handling Protocol for Nonapeptide\u20111 (200mg)<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Proper reconstitution of\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0is critical for maintaining its structural integrity and biological activity.<\/span><\/p>\n<h3><span class=\"\">Step 1 \u2013 Preparation<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Bring the sealed Nonapeptide\u20111 vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH\u202f5\u20117) to room temperature.\u00a0<\/span><em><span class=\"\">Condensation can degrade the lyophilised powder.<\/span><\/em><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 2 \u2013 Vial Sanitisation<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Wipe the rubber stopper of the Nonapeptide\u20111 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 3 \u2013 Reconstitution<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is\u00a0<\/span><strong><span class=\"\">200\u202fmg per 20\u202fmL of diluent<\/span><\/strong><span class=\"\">, yielding a\u00a0<\/span><strong><span class=\"\">10\u202fmg\/mL<\/span><\/strong><span class=\"\">\u00a0stock solution.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Insert the needle and slowly inject the diluent\u00a0<\/span><strong><span class=\"\">against the inner glass wall<\/span><\/strong><span class=\"\">. Do not spray directly onto the lyophilised powder.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Gently swirl the vial until the solution is clear and fully dissolved.\u00a0<\/span><strong><span class=\"\">Do not shake vigorously<\/span><\/strong><span class=\"\">, as shaking can cause denaturation.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 4 \u2013 Aliquoting &amp; Storage<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Immediately after dissolution, aliquot the reconstituted Nonapeptide\u20111 into single\u2011use sterile vials.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Store aliquots at \u201320\u00b0C. Avoid repeated freeze\u2011thaw cycles.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Once thawed, store at 2\u20118\u00b0C and use within\u00a0<\/span><strong><span class=\"\">28 days<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Concentration Reference Table for Nonapeptide-1 (200mg)<\/span><\/h3>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Vial Mass<\/span><\/th>\n<th><span class=\"\">Diluent Volume<\/span><\/th>\n<th><span class=\"\">Final Concentration<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"\">200\u202fmg<\/span><\/td>\n<td><span class=\"\">20\u202fmL<\/span><\/td>\n<td><span class=\"\">10\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">200\u202fmg<\/span><\/td>\n<td><span class=\"\">10\u202fmL<\/span><\/td>\n<td><span class=\"\">20\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">200\u202fmg<\/span><\/td>\n<td><span class=\"\">40\u202fmL<\/span><\/td>\n<td><span class=\"\">5\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"ds-markdown-paragraph\"><em><span class=\"\">Adjust diluent volume based on your experimental requirements. Nonapeptide\u20111 is fully soluble in water at these concentrations.<\/span><\/em><\/p>\n<h2><span class=\"\">Storage &amp; Stability Guidelines for Nonapeptide-1 (200mg)<\/span><\/h2>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Storage Condition<\/span><\/th>\n<th><span class=\"\">Shelf Life<\/span><\/th>\n<th><span class=\"\">Notes<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"\">Lyophilised at \u201320\u00b0C, unopened<\/span><\/td>\n<td><span class=\"\">2 years<\/span><\/td>\n<td><span class=\"\">Use desiccant, protect from light.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Lyophilised at 2\u20118\u00b0C, unopened<\/span><\/td>\n<td><span class=\"\">6\u201112 months<\/span><\/td>\n<td><span class=\"\">\u201320\u00b0C storage is strongly preferred for long\u2011term stability.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Reconstituted at 2\u20118\u00b0C<\/span><\/td>\n<td><span class=\"\">Up to 28 days<\/span><\/td>\n<td><span class=\"\">Must be sterile; use aseptic technique for each withdrawal.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Reconstituted aliquots at \u201320\u00b0C<\/span><\/td>\n<td><span class=\"\">Up to 3 months<\/span><\/td>\n<td><span class=\"\">Single freeze only; discard after thawing.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2><span class=\"\">Why Choose Wuhan Top Miracle Peptides for Nonapeptide\u20111 (200mg)?<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">As an authentic licensed peptide supplier based in the\u00a0<\/span><strong><span class=\"\">United Kingdom<\/span><\/strong><span class=\"\">, we supply\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0and a wide range of research\u2011grade compounds under rigorous quality assurance protocols, fully aligned with Google&#8217;s\u00a0<\/span><strong><span class=\"\">E\u2011E\u2011A\u2011T<\/span><\/strong><span class=\"\">\u00a0standards (Experience, Expertise, Authoritativeness, Trustworthiness).<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Verified Purity:<\/span><\/strong><span class=\"\">\u00a0Independent HPLC analysis with purity guaranteed\u00a0<\/span><strong><span class=\"\">\u226598%<\/span><\/strong><span class=\"\">\u00a0for every batch.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">GMP\u2011Compliant Manufacturing:<\/span><\/strong><span class=\"\">\u00a0All peptides are synthesised in ISO\u202f13485:2016 and GMP\u2011certified facilities, ensuring batch\u2011to\u2011batch consistency.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Full Traceability:<\/span><\/strong><span class=\"\">\u00a0Batch\u2011specific Certificates of Analysis (COA) are available for every order.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Wholesale Supply:<\/span><\/strong><span class=\"\">\u00a0We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">UK\u2011Based Regulatory Compliance:<\/span><\/strong><span class=\"\">\u00a0All products are supplied strictly as research\u2011grade chemicals for laboratory use only (RUO).<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Researchers across the United Kingdom\u2014including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh\u2014trust us for fast domestic delivery, transparent documentation and professional technical support.<\/span><\/p>\n<h2><span class=\"\">FAQ: Nonapeptide\u20111 (200mg) Research Peptide<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">\u00a0What is Nonapeptide\u20111 (200mg) research peptide?<\/span><\/strong><br \/>\n<span class=\"\">Nonapeptide\u20111 (Melanostatine\u20115) is a synthetic nine\u2011amino\u2011acid peptide that acts as a selective antagonist of the melanocortin\u20111 receptor (MC1R). It competitively blocks \u03b1\u2011MSH binding, inhibiting cAMP elevation, melanosome dispersion, and melanin synthesis<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What is the sequence and molecular weight of Nonapeptide\u20111?<\/span><\/strong><br \/>\n<span class=\"\">The sequence is\u00a0<\/span><strong><span class=\"\">Met\u2011Pro\u2011D\u2011Phe\u2011Arg\u2011D\u2011Trp\u2011Phe\u2011Lys\u2011Pro\u2011Val\u2011NH\u2082<\/span><\/strong><span class=\"\">. Its molecular formula is C\u2086\u2081H\u2088\u2087N\u2081\u2085O\u2089S, and its molecular weight is approximately\u00a0<\/span><strong><span class=\"\">1206.5 g\/mol<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What are the primary research applications for Nonapeptide\u20111?<\/span><\/strong><br \/>\n<span class=\"\">Nonapeptide\u20111 is used in melanogenesis and pigmentation research, MC1R receptor pharmacology studies, adrenal steroidogenesis research, skin cancer research, and formulation\/nanotechnology research.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What is the mechanism of action of Nonapeptide\u20111?<\/span><\/strong><br \/>\n<span class=\"\">Nonapeptide\u20111 acts as a competitive antagonist at the MC1R (Ki = 40 nM). It blocks \u03b1\u2011MSH\u2011induced cAMP elevation (IC\u2085\u2080 = 2.5 nM) and melanosome dispersion (IC\u2085\u2080 = 11 nM), and downregulates tyrosinase, TRP\u20111, TRP\u20112, and MITF<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What purity does your Nonapeptide\u20111 (200mg) meet?<\/span><\/strong><br \/>\n<span class=\"\">Our Nonapeptide\u20111 is tested to\u00a0<\/span><strong><span class=\"\">\u226598% purity<\/span><\/strong><span class=\"\">\u00a0by HPLC. A Certificate of Analysis (COA) is supplied with every order.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">How should I reconstitute Nonapeptide\u20111 (200mg)?<\/span><\/strong><br \/>\n<span class=\"\">Reconstitute with sterile bacteriostatic water or sterile PBS (pH\u202f5\u20117). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">How should I store reconstituted Nonapeptide\u20111?<\/span><\/strong><br \/>\n<span class=\"\">Reconstituted Nonapeptide\u20111 should be stored at 2\u20118\u00b0C and used within 28 days. For longer storage, aliquot immediately into single\u2011use vials and store at \u201320\u00b0C for up to 3 months. Avoid repeated freeze\u2011thaw cycles.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Is Nonapeptide\u20111 research peptide legal to purchase in the UK?<\/span><\/strong><br \/>\n<span class=\"\">Yes. Nonapeptide\u20111 is a laboratory reagent sold for\u00a0<\/span><strong><span class=\"\">research use only (RUO)<\/span><\/strong><span class=\"\">. It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in\u2011vitro or in\u2011vivo scientific research, provided it is not marketed with therapeutic claims.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Does Wuhan Top Miracle Peptides ship internationally?<\/span><\/strong><br \/>\n<span class=\"\">Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.<\/span><\/p>\n<h2>Wholesale Nonapeptide-1 200mg Supply Across the UK and Europe<\/h2>\n<p class=\"isSelectedEnd\">Wuhan Top Miracle Peptides supports wholesale peptide and cosmetic ingredient buyers in the United Kingdom and international markets.<\/p>\n<h3>We Support Enquiries From:<\/h3>\n<ul data-spread=\"false\">\n<li>United Kingdom<\/li>\n<li>France<\/li>\n<li>Germany<\/li>\n<li>Spain<\/li>\n<li>Sweden<\/li>\n<li>Italy<\/li>\n<li>USA<\/li>\n<li>Wider Europe<\/li>\n<\/ul>\n<p class=\"isSelectedEnd\">For larger Nonapeptide-1 200mg enquiries, contact our team before ordering. This helps confirm stock, wholesale pricing, documentation, shipping options, and buyer requirements.<\/p>\n<h2>Where to Buy Nonapeptide-1 200mg in the UK<\/h2>\n<p class=\"isSelectedEnd\">If you are searching for <strong>where to buy Nonapeptide-1 200mg in the UK<\/strong>, Wuhan Top Miracle Peptides provides a simple research-focused enquiry process.<\/p>\n<h3>How to Order<\/h3>\n<ol start=\"1\" data-spread=\"false\">\n<li>Review the Nonapeptide-1 200mg product details.<\/li>\n<li>Check the current label and batch information.<\/li>\n<li>Confirm the INCI name or product identity from documentation.<\/li>\n<li>Ask about COA and purity-related documentation.<\/li>\n<li>Confirm your shipping country.<\/li>\n<li>Discuss wholesale quantity requirements.<\/li>\n<li>Place your enquiry with support from our team.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/bulk-orders\/\"><strong>Bulk Peptides Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/shipping-returns\/\"><strong>Shipping &amp; Returns Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/contact-us\/\"><strong>Contact Us Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/shop-3\/\"><strong>Shop Page<\/strong><\/a><br \/>\n<strong>Quality \/ Compliance Page<\/strong><br \/>\n<strong>Google Search Central<\/strong><br \/>\n<strong>GOV.UK \/ MHRA<\/strong><br \/>\n<strong>ASA \/ CAP Code Section 12<\/strong><br \/>\n<strong>Scientific or ingredient reference source such as PubMed, NCBI, PubChem, CosIng, or an official cosmetic ingredient database<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">From its design as a selective MC1R antagonist to its well\u2011characterised role in inhibiting \u03b1\u2011MSH signalling, cAMP elevation, and melanin synthesis,\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0provides a precisely defined platform for advanced dermatological and receptor research. Its ability to modulate the melanogenesis pathway through competitive receptor antagonism\u2014supported by high\u2011affinity binding (Ki = 40 nM), potent in vitro activity (IC\u2085\u2080 = 2.5 nM for cAMP inhibition), and documented downregulation of key melanogenic enzymes\u2014makes it a valuable addition to any laboratory investigating pigmentation, MC1R pharmacology, or related signalling pathways<\/span><span class=\"\">. By choosing high\u2011purity, lab\u2011verified\u00a0<\/span><strong><span class=\"\">Nonapeptide-1 (200mg) research peptide<\/span><\/strong><span class=\"\">\u00a0from\u00a0<\/span><strong><span class=\"\">Wuhan Top Miracle Peptides<\/span><\/strong><span class=\"\">, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Ready to advance your research with Nonapeptide\u20111 (200mg)?<\/span><\/strong><span class=\"\">\u00a0Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory&#8217;s specific needs.\u00a0<\/span><strong><span class=\"\">Place your order now<\/span><\/strong><span class=\"\">\u00a0and receive GMP\u2011grade Nonapeptide\u20111 delivered directly to your facility in the UK, EU, or USA.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<h2>Nonapeptide-1 (200mg)<\/h2>\n<p>High-purity Nonapeptide-1 (200mg) research peptide for melanogenesis &amp; MC1R studies. \u03b1-MSH antagonist, \u226598% purity. Trusted UK\/EU wholesale supplier.<\/p>\n","protected":false},"featured_media":239,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[647,268,654,241,585,650,646,643,651,644,642,641,645,648,649,639,638,653,640,232,256,212,266,215,652,269,218,239],"class_list":["post-929","product","type-product","status-publish","has-post-thumbnail","product_cat-peptides","product_tag-cheap-nonapeptide-1-uk","product_tag-coa-peptide-supplier-uk","product_tag-cosmetic-formulation-peptide-uk","product_tag-cosmetic-peptide-supplier-uk","product_tag-cosmetic-research-peptide-uk","product_tag-nonapeptide-1-200mg-peptide","product_tag-nonapeptide-1-anti-ageing-guaranteed","product_tag-nonapeptide-1-before-and-after","product_tag-nonapeptide-1-cosmetic-peptide","product_tag-nonapeptide-1-dosage","product_tag-nonapeptide-1-for-hyperpigmentation-treatment","product_tag-nonapeptide-1-for-melasma","product_tag-nonapeptide-1-injection-guide","product_tag-nonapeptide-1-no-prescription","product_tag-nonapeptide-1-peptide-uk","product_tag-nonapeptide-1-removes-dark-spots","product_tag-nonapeptide-1-skin-whitening-results","product_tag-nonapeptide-1-supplier-uk","product_tag-nonapeptide-1-treats-pigmentation","product_tag-peptide-purity-uk","product_tag-peptide-supplier-europe","product_tag-peptides-for-sale-uk","product_tag-professional-peptide-supplier-uk","product_tag-research-peptides-europe","product_tag-research-grade-nonapeptide-1","product_tag-uk-peptide-supplier","product_tag-where-to-buy-peptides-in-uk","product_tag-wholesale-peptides-uk","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product\/929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/comments?post=929"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/media\/239"}],"wp:attachment":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/media?parent=929"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_brand?post=929"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=929"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}