{"id":932,"date":"2026-05-25T03:50:06","date_gmt":"2026-05-25T03:50:06","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&#038;p=932"},"modified":"2026-06-20T18:11:15","modified_gmt":"2026-06-20T18:11:15","slug":"p21","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/p21\/","title":{"rendered":"P21"},"content":{"rendered":"<h1><span class=\"\">P21 Research Peptide: A Dual\u2011Action Tool for Neurodegeneration &amp; Cell Cycle Studies<\/span><\/h1>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">If your research investigates neurodegenerative disease, neurogenesis, or the molecular mechanisms of cell cycle regulation,\u00a0<\/span><strong><span class=\"\">P21 research peptide<\/span><\/strong><span class=\"\">\u00a0represents a precisely defined synthetic tool with growing scientific interest. Also known as P021, this small tetra\u2011peptide (Ac\u2011DGGL(A)G\u2011NH\u2082) is derived from the most active region of ciliary neurotrophic factor (CNTF)\u2014a potent neurotrophic factor that promotes neuronal survival and differentiation<\/span><span class=\"\">. Unlike full\u2011length CNTF, which is too large to cross the blood\u2011brain barrier and has poor plasma stability, P21 is small enough to penetrate the central nervous system while retaining neurotrophic activity<\/span><span class=\"\">. Its unique design also allows it to mimic the functional domains of the cyclin\u2011dependent kinase inhibitor p21, making it a valuable tool for studying both neurotrophic signalling and cell cycle dynamics. <\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">At\u00a0<\/span><strong><span class=\"\">Wuhan Top Miracle Peptides<\/span><\/strong><span class=\"\">, we supply high\u2011purity\u00a0<\/span><strong><span class=\"\">P21 research peptide<\/span><\/strong><span class=\"\">\u00a0to research institutions and wholesale buyers across the\u00a0<\/span><strong><span class=\"\">United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong><span class=\"\">. Every batch is lyophilised, HPLC\u2011verified to \u226598% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into neurodegeneration, neurogenesis, and cell cycle regulation begin with uncompromising quality.<\/span><\/p>\n<h2><span class=\"\">What Is P21 and How Does It Work?<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">To fully appreciate the research potential of\u00a0<\/span><strong><span class=\"\">P21 research peptide<\/span><\/strong><span class=\"\">, it is essential to understand its biochemical design and the dual mechanisms by which it exerts its effects.<\/span><\/p>\n<h3><span class=\"\">The Ac\u2011DGGL(A)G\u2011NH\u2082 Tetra\u2011Peptide<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">P21 is a synthetic tetra\u2011peptide (in some formulations, a pentapeptide when the C\u2011terminal adamantane group is counted) with the sequence\u00a0<\/span><strong><span class=\"\">Ac\u2011Asp\u2011Gly\u2011Gly\u2011Leu\u2011(A)G\u2011NH\u2082<\/span><\/strong><span class=\"\">, where (A) represents an adamantane group<\/span><span class=\"\">. Its molecular formula is\u00a0<\/span><strong><span class=\"\">C\u2082\u2087H\u2084\u2082N\u2086O\u2088<\/span><\/strong><span class=\"\">\u00a0(or C\u2083\u2080H\u2085\u2084N\u2086O\u2085), and its molecular weight is approximately\u00a0<\/span><strong><span class=\"\">578.67 g\/mol<\/span><\/strong><span class=\"\">. It has a CAS number of\u00a0<\/span><strong><span class=\"\">1246751\u201168\u20117<\/span><\/strong><span class=\"\">. The N\u2011terminal acetylation and C\u2011terminal amidation enhance the peptide&#8217;s stability<\/span><span class=\"\">. The incorporation of an adamantane group at the C\u2011terminus is a key structural feature\u2014it enhances the peptide&#8217;s stability and improves its ability to cross the blood\u2011brain barrier<\/span><span class=\"\">.<\/span><\/p>\n<h3><span class=\"\">Mechanism of Action: Dual Neurotrophic and Cell Cycle Pathways<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The biological activity of\u00a0<\/span><strong><span class=\"\">P21 research peptide<\/span><\/strong><span class=\"\">\u00a0is rooted in its ability to act as a CNTF mimetic and a modulator of cell cycle regulation<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">CNTF Mimetic and Neurotrophic Signalling:<\/span><\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">BDNF\/TrkB Pathway Activation:<\/span><\/strong><span class=\"\">\u00a0P21 activates the BDNF\u2011TrkB\u2011PI3K\u2011AKT\u2011GSK3\u03b2 signalling pathway, a cascade critical for neuronal survival, synaptic plasticity, and neurogenesis<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Neuroprotection and Neurogenesis:<\/span><\/strong><span class=\"\">\u00a0In laboratory animal studies, P21 has been reported to increase levels of brain\u2011derived neurotrophic factor (BDNF), thus promoting neurogenesis (nerve growth) and inhibiting the formation of amyloid plaques and tau proteins seen in Alzheimer&#8217;s disease<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Tau and Amyloid Pathology:<\/span><\/strong><span class=\"\">\u00a0P21 has been shown to attenuate robustly tau and mildly A\u03b2 pathologies in 3xTg\u2011AD mouse models<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">LIF Pathway Modulation:<\/span><\/strong><span class=\"\">\u00a0P21 competitively inhibits the leukemia inhibitory factor (LIF) signalling pathway, which is known to inhibit the formation of neural progenitor cells from stem cells<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Cell Cycle Regulation and CDK Inhibition:<\/span><\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">CDK\u2011Cyclin Complex Inhibition:<\/span><\/strong><span class=\"\">\u00a0P21 mimics the functional domains of endogenous p21, allowing it to inhibit cyclin\u2011dependent kinase (CDK) activity in vitro, thereby facilitating the study of G1\/S and G2\/M phase transitions<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">PCNA Interaction:<\/span><\/strong><span class=\"\">\u00a0P21 also interacts with proliferating cell nuclear antigen (PCNA), a key regulator of DNA replication and repair<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"\">Key Research Applications for P21<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">P21 research peptide<\/span><\/strong><span class=\"\">\u00a0is a versatile tool with applications spanning several domains of biomedical research.<\/span><\/p>\n<h3><span class=\"\">\u00a0Neurodegenerative Disease &amp; Alzheimer&#8217;s Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The most extensively studied application of P21 lies in its potential as a disease\u2011modifying agent for neurodegenerative conditions. Research has demonstrated:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Amyloid and Tau Pathology Reduction:<\/span><\/strong><span class=\"\">\u00a0P21 attenuated robustly tau and mildly A\u03b2 pathologies in 3xTg\u2011AD mice<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Rescue of Cognitive Deficits:<\/span><\/strong><span class=\"\">\u00a0P21 could rescue deficits in neurogenesis, neuronal plasticity, and cognition<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Disease\u2011Modifying Potential:<\/span><\/strong><span class=\"\">\u00a0P21 is considered a potential disease\u2011modifying treatment for Alzheimer&#8217;s disease<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">In a landmark study, P021 treatment was able to rescue dendritic and synaptic deficits, boost neurogenesis, and reverse cognitive impairment in 3 \u00d7 Tg\u2011AD mice<\/span><span class=\"\">.<\/span><\/p>\n<h3><span class=\"\">Neurogenesis &amp; Neuronal Plasticity Research<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">P21&#8217;s ability to increase BDNF levels positions it as a valuable tool for studying:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Adult Neurogenesis:<\/span><\/strong><span class=\"\">\u00a0The mechanisms underlying the generation of new neurons in the adult brain<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Synaptic Plasticity:<\/span><\/strong><span class=\"\">\u00a0The molecular pathways involved in learning and memory formation<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Neuronal Survival:<\/span><\/strong><span class=\"\">\u00a0The signalling cascades that promote neuronal survival and differentiation<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Cell Cycle &amp; Proliferation Studies<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">P21 serves as a functional probe for dissecting cell cycle control mechanisms<\/span><span class=\"\">:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">CDK Inhibition Studies:<\/span><\/strong><span class=\"\">\u00a0Investigating how p21\u2011mediated inhibition of CDK\u2011cyclin complexes contributes to cell cycle arrest in response to DNA damage or oncogenic stress<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">G1\/S and G2\/M Phase Transitions:<\/span><\/strong><span class=\"\">\u00a0Studying the regulatory checkpoints that control cell cycle progression<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Tumour Suppressor Pathways:<\/span><\/strong><span class=\"\">\u00a0Elucidating the role of p21 in tumour suppression and cellular stress responses.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Protein\u2011Protein Interaction Mapping<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The peptide serves as a valuable probe for investigating molecular interactions:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">p21\u2011CDK Interactions:<\/span><\/strong><span class=\"\">\u00a0Characterising the affinity and specificity of p21 interactions with cyclin\u2011dependent kinases<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">p21\u2011PCNA Interactions:<\/span><\/strong><span class=\"\">\u00a0Mapping critical contact residues and exploring the structural determinants of these complexes<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Drug Discovery &amp; Peptide\u2011Based Screening<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">In drug discovery and chemical biology, P21 provides a functional template for:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">High\u2011Throughput Assays:<\/span><\/strong><span class=\"\">\u00a0Evaluating the efficacy of candidate compounds in disrupting or enhancing p21\u2011CDK protein\u2011protein interactions.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Inhibitor Design:<\/span><\/strong><span class=\"\">\u00a0Developing small\u2011molecule inhibitors or mimetics targeting the p21\u2011CDK interface<\/span><span class=\"\">.<\/span><\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"\">Chemical &amp; Physical Specifications<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Accurate characterisation of\u00a0<\/span><strong><span class=\"\">P21 research peptide<\/span><\/strong><span class=\"\">\u00a0is essential for reproducible experimental design.<\/span><\/p>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Parameter<\/span><\/th>\n<th><span class=\"\">Specification<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong><span class=\"\">Common Names<\/span><\/strong><\/td>\n<td><span class=\"\">P21, P021, Peptide 021<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Amino Acid Sequence (One\u2011Letter)<\/span><\/strong><\/td>\n<td><span class=\"\">Ac\u2011DGGL(A)G\u2011NH\u2082<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Amino Acid Sequence (Three\u2011Letter)<\/span><\/strong><\/td>\n<td><span class=\"\">Ac\u2011Asp\u2011Gly\u2011Gly\u2011Leu\u2011(A)Gly\u2011NH\u2082<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Molecular Formula<\/span><\/strong><\/td>\n<td><span class=\"\">C\u2082\u2087H\u2084\u2082N\u2086O\u2088<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Molecular Weight<\/span><\/strong><\/td>\n<td><span class=\"\">~578.67 g\/mol<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">CAS Number<\/span><\/strong><\/td>\n<td><span class=\"\">1246751\u201168\u20117<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Purity<\/span><\/strong><\/td>\n<td><strong><span class=\"\">\u226598%<\/span><\/strong><span class=\"\">\u00a0(HPLC verified)<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Appearance<\/span><\/strong><\/td>\n<td><span class=\"\">White powder<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Solubility<\/span><\/strong><\/td>\n<td><span class=\"\">Soluble in sterile water and sterile PBS (pH 5\u20117)<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Storage (Lyophilised)<\/span><\/strong><\/td>\n<td><span class=\"\">\u201320\u00b0C, sealed, protected from light; stable for up to 2 years<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span class=\"\">Storage (Reconstituted)<\/span><\/strong><\/td>\n<td><span class=\"\">2\u20118\u00b0C for up to 28 days; single\u2011use aliquots at \u201320\u00b0C for up to 3 months<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<blockquote>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Note:<\/span><\/strong><span class=\"\">\u00a0The adamantane group ((A) in the sequence) is a bulky hydrophobic moiety that enhances peptide stability and blood\u2011brain barrier penetration<\/span><span class=\"\">.<\/span><\/p>\n<\/blockquote>\n<h2><span class=\"\">Reconstitution &amp; Handling Protocol for P21<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Proper reconstitution of\u00a0<\/span><strong><span class=\"\">P21 research peptide<\/span><\/strong><span class=\"\">\u00a0is critical for maintaining its structural integrity and biological activity.<\/span><\/p>\n<h3><span class=\"\">Step 1 \u2013 Preparation<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Bring the sealed P21 vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH\u202f5\u20117) to room temperature.\u00a0<\/span><em><span class=\"\">Condensation can degrade the lyophilised powder.<\/span><\/em><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 2 \u2013 Vial Sanitisation<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Wipe the rubber stopper of the P21 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 3 \u2013 Reconstitution<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Draw your desired volume of diluent into a sterile syringe. A typical starting concentration for research applications is\u00a0<\/span><strong><span class=\"\">1\u202fmg per 1\u202fmL of diluent<\/span><\/strong><span class=\"\">, yielding a\u00a0<\/span><strong><span class=\"\">1\u202fmg\/mL<\/span><\/strong><span class=\"\">\u00a0stock solution.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Insert the needle and slowly inject the diluent\u00a0<\/span><strong><span class=\"\">against the inner glass wall<\/span><\/strong><span class=\"\">. Do not spray directly onto the lyophilised powder.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Gently swirl the vial until the solution is clear and fully dissolved.\u00a0<\/span><strong><span class=\"\">Do not shake vigorously<\/span><\/strong><span class=\"\">, as shaking can cause denaturation.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Step 4 \u2013 Aliquoting &amp; Storage<\/span><\/h3>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Immediately after dissolution, aliquot the reconstituted P21 into single\u2011use sterile vials.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Store aliquots at \u201320\u00b0C. Avoid repeated freeze\u2011thaw cycles.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Once thawed, store at 2\u20118\u00b0C and use within a short period.<\/span><\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"\">Concentration Reference Table<\/span><\/h3>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Vial Mass<\/span><\/th>\n<th><span class=\"\">Diluent Volume<\/span><\/th>\n<th><span class=\"\">Final Concentration<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"\">1\u202fmg<\/span><\/td>\n<td><span class=\"\">1.0\u202fmL<\/span><\/td>\n<td><span class=\"\">1\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">5\u202fmg<\/span><\/td>\n<td><span class=\"\">5.0\u202fmL<\/span><\/td>\n<td><span class=\"\">1\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">10\u202fmg<\/span><\/td>\n<td><span class=\"\">10.0\u202fmL<\/span><\/td>\n<td><span class=\"\">1\u202fmg\/mL<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"ds-markdown-paragraph\"><em><span class=\"\">Adjust diluent volume based on your experimental requirements. For cell culture applications, further dilute to working concentrations (typically 10\u2011100\u202f\u00b5M).<\/span><\/em><\/p>\n<h2><span class=\"\">Storage &amp; Stability Guidelines<\/span><\/h2>\n<div class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\">\n<div class=\"ds-scroll-area__gutters\">\n<div class=\"ds-scroll-area__horizontal-gutter\"><\/div>\n<div class=\"ds-scroll-area__vertical-gutter\"><\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th><span class=\"\">Storage Condition<\/span><\/th>\n<th><span class=\"\">Shelf Life<\/span><\/th>\n<th><span class=\"\">Notes<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"\">Lyophilised at \u201320\u00b0C, unopened<\/span><\/td>\n<td><span class=\"\">2 years<\/span><\/td>\n<td><span class=\"\">Use desiccant, protect from light.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Lyophilised at 2\u20118\u00b0C, unopened<\/span><\/td>\n<td><span class=\"\">6\u201112 months<\/span><\/td>\n<td><span class=\"\">\u201320\u00b0C storage is strongly preferred for long\u2011term stability.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Reconstituted at 2\u20118\u00b0C<\/span><\/td>\n<td><span class=\"\">Short\u2011term use<\/span><\/td>\n<td><span class=\"\">Use within days to weeks.<\/span><\/td>\n<\/tr>\n<tr>\n<td><span class=\"\">Reconstituted aliquots at \u201320\u00b0C<\/span><\/td>\n<td><span class=\"\">Up to 3 months<\/span><\/td>\n<td><span class=\"\">Single freeze only; discard after thawing.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2><span class=\"\">Why Choose Wuhan Top Miracle Peptides for P21?<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">As an authentic licensed peptide supplier based in the\u00a0<\/span><strong><span class=\"\">United Kingdom<\/span><\/strong><span class=\"\">, we supply\u00a0<\/span><strong><span class=\"\">P21 research peptide<\/span><\/strong><span class=\"\">\u00a0and a wide range of research\u2011grade compounds under rigorous quality assurance protocols, fully aligned with Google&#8217;s\u00a0<\/span><strong><span class=\"\">E\u2011E\u2011A\u2011T<\/span><\/strong><span class=\"\">\u00a0standards (Experience, Expertise, Authoritativeness, Trustworthiness).<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Verified Purity:<\/span><\/strong><span class=\"\">\u00a0Independent HPLC analysis with purity guaranteed\u00a0<\/span><strong><span class=\"\">\u226598%<\/span><\/strong><span class=\"\">\u00a0for every batch.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">GMP\u2011Compliant Manufacturing:<\/span><\/strong><span class=\"\">\u00a0All peptides are synthesised in ISO\u202f13485:2016 and GMP\u2011certified facilities, ensuring batch\u2011to\u2011batch consistency.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Full Traceability:<\/span><\/strong><span class=\"\">\u00a0Batch\u2011specific Certificates of Analysis (COA) are available for every order.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Wholesale Supply:<\/span><\/strong><span class=\"\">\u00a0We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">UK\u2011Based Regulatory Compliance:<\/span><\/strong><span class=\"\">\u00a0All products are supplied strictly as research\u2011grade chemicals for laboratory use only (RUO).<\/span><\/p>\n<\/li>\n<\/ul>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Researchers across the United Kingdom\u2014including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh\u2014trust us for fast domestic delivery, transparent documentation and professional technical support.<\/span><\/p>\n<h2><span class=\"\">FAQ: P21 Research Peptide<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What is P21 research peptide?<\/span><\/strong><br \/>\n<span class=\"\">P21 (also known as P021) is a synthetic tetra\u2011peptide (Ac\u2011DGGL(A)G\u2011NH\u2082) derived from the active region of ciliary neurotrophic factor (CNTF)<\/span><span class=\"\">. It acts as a CNTF mimetic and a modulator of cell cycle regulation, making it a valuable tool for neurodegeneration, neurogenesis, and cell cycle research<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What is the sequence and molecular weight of P21?<\/span><\/strong><br \/>\n<span class=\"\">The sequence is\u00a0<\/span><strong><span class=\"\">Ac\u2011Asp\u2011Gly\u2011Gly\u2011Leu\u2011(A)Gly\u2011NH\u2082<\/span><\/strong><span class=\"\">\u00a0(Ac\u2011DGGL(A)G\u2011NH\u2082)<\/span><span class=\"\">. Its molecular weight is approximately\u00a0<\/span><strong><span class=\"\">578.67 g\/mol<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What are the primary research applications for P21?<\/span><\/strong><br \/>\n<span class=\"\">P21 is used in neurodegenerative disease and Alzheimer&#8217;s research, neurogenesis and neuronal plasticity studies, cell cycle and proliferation studies, protein\u2011protein interaction mapping, and drug discovery and peptide\u2011based screening.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What is the mechanism of action of P21?<\/span><\/strong><br \/>\n<span class=\"\">P21 acts through dual pathways: as a CNTF mimetic, it activates the BDNF\u2011TrkB\u2011PI3K\u2011AKT\u2011GSK3\u03b2 pathway, promoting neuroprotection and neurogenesis<\/span><span class=\"\">. As a CDK inhibitor, it modulates cell cycle progression by inhibiting CDK\u2011cyclin complexes<\/span><span class=\"\">.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">What purity does your P21 research peptide meet?<\/span><\/strong><br \/>\n<span class=\"\">Our P21 is tested to\u00a0<\/span><strong><span class=\"\">\u226598% purity<\/span><\/strong><span class=\"\">\u00a0by HPLC. A Certificate of Analysis (COA) is supplied with every order.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">How should I reconstitute P21 research peptide?<\/span><\/strong><br \/>\n<span class=\"\">Reconstitute with sterile bacteriostatic water or sterile PBS (pH\u202f5\u20117). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">How should I store reconstituted P21?<\/span><\/strong><br \/>\n<span class=\"\">Reconstituted P21 should be stored at 2\u20118\u00b0C for short\u2011term use. For longer storage, aliquot immediately into single\u2011use vials and store at \u201320\u00b0C for up to 3 months. Avoid repeated freeze\u2011thaw cycles.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Is P21 research peptide legal to purchase in the UK?<\/span><\/strong><br \/>\n<span class=\"\">Yes. P21 is a laboratory reagent sold for\u00a0<\/span><strong><span class=\"\">research use only (RUO)<\/span><\/strong><span class=\"\">. It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in\u2011vitro or in\u2011vivo scientific research, provided it is not marketed with therapeutic claims.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Does Wuhan Top Miracle Peptides ship internationally?<\/span><\/strong><br \/>\n<span class=\"\">Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.<\/span><\/p>\n<h2>Wholesale P21 Peptide Supply Across the UK and Europe<\/h2>\n<p class=\"isSelectedEnd\">Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.<\/p>\n<h3>We Support Enquiries From:<\/h3>\n<ul data-spread=\"false\">\n<li>United Kingdom<\/li>\n<li>France<\/li>\n<li>Germany<\/li>\n<li>Spain<\/li>\n<li>Sweden<\/li>\n<li>Italy<\/li>\n<li>USA<\/li>\n<li>Wider Europe<\/li>\n<\/ul>\n<p class=\"isSelectedEnd\">For larger P21 enquiries, contact our team before ordering. This helps confirm stock, documentation, shipping options, and buyer verification requirements.<\/p>\n<h2>Where to Source P21 Peptide in the UK<\/h2>\n<p class=\"isSelectedEnd\">If you are searching for <strong>where to source P21 peptide in the UK<\/strong>, Wuhan Top Miracle Peptides provides a simple professional enquiry process.<\/p>\n<h3>Professional Enquiry Process<\/h3>\n<ol start=\"1\" data-spread=\"false\">\n<li>Review the P21 product details.<\/li>\n<li>Check the current label and batch information.<\/li>\n<li>Confirm the exact product identity from documentation.<\/li>\n<li>Ask whether the batch is listed as P21, P021, Peptide 021, or another verified identity.<\/li>\n<li>Contact our team for availability.<\/li>\n<li>Ask about COA and purity-related documentation.<\/li>\n<li>Confirm your shipping country.<\/li>\n<li>Discuss wholesale quantity requirements.<\/li>\n<li>Complete buyer verification where required.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/bulk-orders\/\"><strong>Bulk Peptides Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/shipping-returns\/\"><strong>Shipping &amp; Returns Page<\/strong><\/a><br \/>\n<a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/contact-us\/\"><strong>Contact Us Page<\/strong><\/a><br \/>\n<code dir=\"ltr\"><\/code><a href=\"https:\/\/wuhantopmiraclepeptides.com\/index.php\/shop-3\/\"><strong>Shop Page<\/strong><\/a><br \/>\n<strong>Quality \/ Compliance Page<\/strong><br \/>\n<strong>PubChem \/ NCBI reference information<\/strong><br \/>\n<strong>PubMed or peer-reviewed research source<\/strong><br \/>\n<strong>GOV.UK \/ MHRA<\/strong><br \/>\n<strong>Google Search Central<\/strong><br \/>\n<strong>ASA \/ CAP Code Section 12<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">From its design as a CNTF mimetic and CDK inhibitor to its well\u2011documented role in reducing amyloid and tau pathology, promoting neurogenesis, and modulating cell cycle progression, <\/span><strong><span class=\"\">\u00a0research peptide<\/span><\/strong><span class=\"\">\u00a0provides a uniquely versatile platform for advanced neurodegenerative and cell cycle research. Its ability to cross the blood\u2011brain barrier and activate the BDNF\u2011TrkB\u2011PI3K\u2011AKT\u2011GSK3\u03b2 pathway\u2014supported by preclinical studies published in peer\u2011reviewed literature<\/span><span class=\"\">\u2014makes it a valuable addition to any laboratory investigating Alzheimer&#8217;s disease, neuroprotection, or cell cycle regulation. By choosing high\u2011purity, lab\u2011verified <\/span><strong><span class=\"\">\u00a0research peptide<\/span><\/strong><span class=\"\">\u00a0from\u00a0<\/span><strong><span class=\"\">Wuhan Top Miracle Peptides<\/span><\/strong><span class=\"\">, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Ready to advance your research with P21?<\/span><\/strong><span class=\"\">\u00a0Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory&#8217;s specific needs.\u00a0<\/span><strong><span class=\"\">Place your order now<\/span><\/strong><span class=\"\"> and receive GMP\u2011grade\u00a0 delivered directly to your facility in the UK, EU, or USA.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>P21 Research Peptide: A Dual\u2011Action Tool for Neurodegeneration &amp; Cell Cycle Studies If your research investigates neurodegenerative disease, neurogenesis, or the molecular mechanisms of cell cycle regulation,\u00a0P21 research peptide\u00a0represents a precisely defined synthetic tool with growing scientific interest. Also known as P021, this small tetra\u2011peptide (Ac\u2011DGGL(A)G\u2011NH\u2082) is derived from the most active region of ciliary [&#8230;]\n","protected":false},"featured_media":242,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[132,268,395,711,122,133,709,705,708,134,707,135,706,710,124,232,212,125,136,637,266,137,126,215,712,269,218,138,239],"class_list":["post-932","product","type-product","status-publish","has-post-thumbnail","product_cat-peptides","product_tag-buy-p21-peptide-online","product_tag-coa-peptide-supplier-uk","product_tag-europe-peptide-supplier","product_tag-glxc-21260-peptide-uk","product_tag-high-purity-peptides","product_tag-p021-peptide-for-sale","product_tag-p021-peptide-uk","product_tag-p21-peptide","product_tag-p21-peptide-documentation","product_tag-p21-peptide-supplier","product_tag-p21-peptide-supplier-uk","product_tag-p21-peptide-wholesale","product_tag-p21-research-peptide","product_tag-peptide-021-uk","product_tag-peptide-purity","product_tag-peptide-purity-uk","product_tag-peptides-for-sale-uk","product_tag-peptides-for-sale-usa","product_tag-peptides-usa","product_tag-professional-peptide-enquiry-uk","product_tag-professional-peptide-supplier-uk","product_tag-ptide-coa-documentation","product_tag-research-peptides","product_tag-research-peptides-europe","product_tag-research-grade-p21-peptide","product_tag-uk-peptide-supplier","product_tag-where-to-buy-peptides-in-uk","product_tag-wholesale","product_tag-wholesale-peptides-uk","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product\/932","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/comments?post=932"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/media\/242"}],"wp:attachment":[{"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/media?parent=932"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_brand?post=932"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=932"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}