PT-141 (Bremelanotide) is a cyclic synthetic peptide that acts as a melanocortin receptor agonist. It targets MC3R and MC4R receptors in the brain, which are involved in regulating sexual arousal and energy balance. Originally derived from the metabolism of melanotan II, PT-141 is studied for its ability to increase sexual desire and physiological responses in research models. At China Grey Peptides, our PT-141 (10mg) is lab-tested for >99% purity and designed for rigorous laboratory research.<\/p>\n
Parameter<\/span><\/strong><\/th>\n| Detail<\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n\n | Common Names<\/span><\/strong><\/td>\n | PT-141, Bremelanotide, Vyleesi (active ingredient), PT\u2011141<\/span><\/td>\n<\/tr>\n | CAS Number<\/span><\/strong><\/td>\n | 189691-06-3<\/span><\/strong>\u00a0(base)<\/span>\u00a0\/\u00a0<\/span>1607799-13-2<\/span><\/strong>\u00a0(acetate salt)<\/span><\/td>\n<\/tr>\n | Molecular Formula<\/span><\/strong><\/td>\n | C\u2085\u2080H\u2086\u2088N\u2081\u2084O\u2081\u2080<\/span><\/td>\n<\/tr>\n | Molecular Weight<\/span><\/strong><\/td>\n | 1025.18 g\/mol<\/span><\/strong><\/td>\n<\/tr>\n | Purity<\/span><\/strong><\/td>\n | \u226599.6%<\/span><\/strong>\u00a0(by HPLC)<\/span><\/td>\n<\/tr>\n | Source<\/span><\/strong><\/td>\n | Synthetic (cyclic heptapeptide)<\/span><\/td>\n<\/tr>\n | Appearance<\/span><\/strong><\/td>\n | White to off-white lyophilised powder<\/span><\/td>\n<\/tr>\n | Solubility<\/span><\/strong><\/td>\n | Soluble in sterile water (>10 mg\/mL) & sterile PBS (pH 5-7)<\/span><\/td>\n<\/tr>\n | Storage (Lyophilised)<\/span><\/strong><\/td>\n | \u201320\u00b0C, sealed, protected from light; stable for up to 2 years<\/span><\/td>\n<\/tr>\n | Storage (Reconstituted)<\/span><\/strong><\/td>\n | 2\u20118\u00b0C for up to 7 days; single\u2011use aliquots at \u201320\u00b0C for up to 3 months<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n | \n Key Research Applications & Mechanism of Action<\/span><\/h2>\nPT-141 is a synthetic cyclic heptapeptide that acts as a potent melanocortin receptor agonist. Specifically, it targets MC4R (EC\u2085\u2080\u22480.6 nM) and MC3R, bypassing the melanogenic pathway to exert central effects.<\/span>\u00a0It works by binding to melanocortin receptors in hypothalamic regions such as the medial preoptic area (mPOA), where it is hypothesised to promote dopamine release. This can provide insights into CNS receptor pharmacology and its role in neurochemical pathways.<\/span><\/p>\n Understanding its clinical backdrop is essential for any laboratory study. PT-141 received FDA approval in 2019 for use in premenopausal women, which marks it as a unique pharmacological tool. This clinical use (outside of the lab) has produced well-documented pharmacokinetic data, such as a half-life of approximately 2.7 hours, that can help inform research protocols.<\/span><\/p>\n Beyond its sexual behaviour niche, PT-141 serves as a specific molecular probe for investigating melanocortin receptor signalling cascades. It is used to explore how MC3R and MC4R activation influences neural circuits, offering a tool for dissecting pathways associated with appetite control, metabolic signalling, and stress responses.<\/span><\/p>\n PT-141 is a valuable tool for\u00a0<\/span>in vitro<\/span><\/em>\u00a0and\u00a0<\/span>in vivo<\/span><\/em>\u00a0studies examining receptor activation. Preclinical research has documented its ability to induce specific behavioural responses in models without causing generalised motor activation or altering reward perception. This suggests a targeted receptor selectivity that can aid in distinguishing central melanocortin effects from peripheral or off-target ones.<\/span><\/p>\n Proper reconstitution of\u00a0<\/span>PT\u2011141 (10mg)<\/span><\/strong>\u00a0is critical for preserving the structural integrity and activity of this cyclic peptide. This aseptic protocol ensures optimal stability for your experiments.<\/span><\/p>\n Bring the sealed peptide vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5\u20137) to room temperature. Allowing the vial to reach room temperature before opening prevents condensation from degrading the lyophilised powder.<\/span><\/p>\n<\/li>\n Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes, and a clean work mat.<\/span><\/p>\n<\/li>\n<\/ul>\n Wipe the rubber stopper of the PT\u2011141 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.<\/span><\/p>\n<\/li>\n<\/ul>\n Draw\u00a0<\/span>1.0 mL<\/span><\/strong>\u00a0of sterile diluent into a sterile syringe. This will yield a standard research concentration of\u00a0<\/span>10 mg\/mL<\/span><\/strong>.<\/span><\/p>\n<\/li>\n Insert the needle and slowly inject the diluent\u00a0<\/span>against the inner glass wall<\/span><\/strong>. Do not spray directly onto the lyophilised powder.<\/span><\/p>\n<\/li>\n Gently swirl the vial until the solution is clear and fully dissolved.\u00a0<\/span>Do not shake vigorously<\/span><\/strong>, as shaking can cause denaturation.<\/span><\/p>\n<\/li>\n<\/ul>\n Immediately after dissolution, aliquot the reconstituted peptide into single\u2011use sterile vials.<\/span><\/p>\n<\/li>\n Store aliquots at\u00a0<\/span>\u201320\u00b0C<\/span><\/strong>. Avoid repeated freeze\u2011thaw cycles.<\/span><\/p>\n<\/li>\n Once thawed, store at 2\u20118\u00b0C and use within\u00a0<\/span>7 days<\/span><\/strong>. For longer storage, maintain frozen at \u201320\u00b0C and avoid refreezing after thawing.<\/span><\/p>\n<\/li>\n<\/ul>\n Adjust diluent volume based on your experimental requirements.<\/span><\/em><\/p>\n As an authentic licensed peptide supplier based in the\u00a0<\/span>United Kingdom<\/span><\/strong>, we supply\u00a0<\/span>PT\u2011141 (10mg)<\/span><\/strong>\u00a0under rigorous quality assurance protocols, fully aligned with Google’s\u00a0<\/span>E\u2011E\u2011A\u2011T<\/span><\/strong>\u00a0standards.<\/span><\/p>\n Verified Purity:<\/span><\/strong>\u00a0Independent HPLC analysis with purity guaranteed\u00a0<\/span>\u226599%<\/span><\/strong>\u00a0for every batch.<\/span><\/p>\n<\/li>\n |
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