{"id":944,"date":"2026-05-25T03:50:07","date_gmt":"2026-05-25T03:50:07","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&p=944"},"modified":"2026-06-17T02:37:23","modified_gmt":"2026-06-17T02:37:23","slug":"ptd-dbm-5mg","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/ptd-dbm-5mg\/","title":{"rendered":"PTD-DBM (5mg)"},"content":{"rendered":"

PTD-DBM (5mg) Research Peptide: A Cell-Penetrating Tool for Wnt\/\u03b2-Catenin <\/span>Hair Growth Peptide<\/h1>\n
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If your research focuses on regenerative biology, the Wnt\/\u03b2\u2011catenin signalling pathway, or the mechanisms of tissue repair and hair follicle regeneration,\u00a0<\/span>PTD-DBM (5mg) research peptide<\/span><\/strong>\u00a0is a synthetic peptide that warrants serious attention. This engineered 25\u2011amino\u2011acid construct fuses a\u00a0<\/span>Protein Transduction Domain (PTD)<\/span><\/strong>\u00a0\u2014 a poly\u2011arginine cell\u2011penetrating sequence \u2014 with a\u00a0<\/span>Dishevelled Binding Motif (DBM)<\/span><\/strong>\u00a0that competitively inhibits the interaction between the negative feedback regulator CXXC5 and the scaffolding protein Dishevelled (Dvl)<\/span>. By disrupting this interaction, PTD\u2011DBM effectively\u00a0<\/span>disinhibits Wnt\/\u03b2\u2011catenin signalling<\/span><\/strong>, a pathway that governs everything from hair follicle cycling and cutaneous wound healing to stem cell proliferation and tissue patterning<\/span>.<\/span><\/p>\n

At\u00a0<\/span>Wuhan Top Miracle Peptides<\/span><\/strong>, we supply high\u2011purity\u00a0<\/span>PTD-DBM (5mg) research peptide<\/span><\/strong>\u00a0to research institutions and wholesale buyers across the\u00a0<\/span>United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong>. Every batch is lyophilised, HPLC\u2011verified to \u226595% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into regenerative signalling, hair follicle biology, and wound healing begin with uncompromising quality.<\/span><\/p>\n

What Is PTD-DBM and How Does It Work?<\/span><\/h2>\n

To fully appreciate the research potential of\u00a0<\/span>PTD-DBM (5mg) research peptide<\/span><\/strong>, it is essential to understand its innovative design and the precise mechanism by which it modulates Wnt\/\u03b2\u2011catenin signalling.<\/span><\/p>\n

The PTD-DBM Fusion Peptide<\/span><\/h3>\n

PTD\u2011DBM is a synthetic 25\u2011amino\u2011acid peptide with the sequence\u00a0<\/span>RRRRRRRRGGGGRKTGHQICKFRKC<\/span><\/strong>. Its structure encodes two functional domains:<\/span><\/p>\n

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    Protein Transduction Domain (PTD):<\/span><\/strong>\u00a0An N\u2011terminal poly\u2011arginine sequence (eight arginine residues) that confers potent cell\u2011penetrating capabilities<\/span>. This allows the peptide to cross the skin’s stratum corneum and cellular membranes without the need for viral vectors or transfection reagents, delivering the active cargo directly to dermal papilla cells and associated stem cell niches<\/span>.<\/span><\/p>\n<\/li>\n

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    Dishevelled Binding Motif (DBM):<\/span><\/strong>\u00a0A C\u2011terminal domain that physically competes with CXXC5 for binding to the PDZ domain of Dishevelled (Dvl), a key scaffolding protein in canonical Wnt signalling<\/span>.<\/span><\/p>\n<\/li>\n

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    Glycine Linker:<\/span><\/strong>\u00a0A short glycine\u2011rich sequence (GGGG) that covalently links the PTD and DBM domains, ensuring proper spatial orientation and dual functionality<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

    Mechanism of Action: Disinhibiting the Wnt\/\u03b2\u2011Catenin Pathway<\/span><\/h3>\n

    The biological activity of\u00a0<\/span>PTD-DBM (5mg) research peptide<\/span><\/strong>\u00a0is rooted in its ability to disrupt a specific protein\u2011protein interaction:<\/span><\/p>\n

    1. The CXXC5\u2011Dvl Negative Feedback Loop<\/span><\/strong>
    \nCXXC5 (CXXC\u2011type zinc finger protein 5) is a negative feedback regulator of the Wnt\/\u03b2\u2011catenin pathway<\/span>. It binds directly to Dishevelled (Dvl), a scaffolding protein that is essential for propagating Wnt signals from the cell surface to the nucleus<\/span>. This CXXC5\u2011Dvl interaction suppresses downstream Wnt activity, limiting \u03b2\u2011catenin accumulation and transcriptional activation of growth\u2011promoting genes<\/span>.<\/span><\/p>\n

    2. Competitive Inhibition by PTD\u2011DBM<\/span><\/strong>
    \nPTD\u2011DBM acts as a\u00a0<\/span>competitive peptide<\/span><\/strong>\u00a0that blocks the CXXC5\u2011Dvl interaction<\/span>. By occupying the Dvl PDZ domain, it prevents CXXC5 from binding, thereby\u00a0<\/span>disrupting this negative feedback loop<\/span><\/strong>.<\/span><\/p>\n

    3. Reactivation of Wnt\/\u03b2\u2011Catenin Signalling<\/span><\/strong>
    \nWith the CXXC5\u2011mediated brake removed, Dvl is free to propagate Wnt signals. This leads to:<\/span><\/p>\n