{"id":945,"date":"2026-05-25T03:50:07","date_gmt":"2026-05-25T03:50:07","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&p=945"},"modified":"2026-06-17T03:06:16","modified_gmt":"2026-06-17T03:06:16","slug":"receptor-grade-igf-1-lr3-100mcg","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/receptor-grade-igf-1-lr3-100mcg\/","title":{"rendered":"Receptor Grade IGF-1 LR3 (100mcg)"},"content":{"rendered":"

Receptor Grade IGF-1 LR3 (100mcg): A Potent Analogue for Cell Growth & IGF Receptor Studies<\/span><\/h1>\n

If your research focuses on cellular proliferation, IGF-1 receptor signalling, or the mechanisms of anabolic growth,\u00a0<\/span>Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/strong>\u00a0is a reagent that demands your attention. Long Arg3 IGF-1 (LR3-IGF-1) is a synthetic analogue of human insulin-like growth factor 1, engineered for enhanced biological potency and stability<\/span>. Unlike native IGF-1, which is rapidly bound and neutralised by IGF-binding proteins (IGFBPs) in culture media and biological fluids, LR3-IGF-1 has been specifically modified to minimise this interaction<\/span>. The result is a research tool that delivers sustained, high-level activation of the type 1 IGF receptor, driving robust signalling through the PI3K\/AKT and ERK1\/2 pathways<\/span>.<\/span><\/p>\n

At\u00a0<\/span>Wuhan Top Miracle Peptides<\/span><\/strong>, we supply high-purity\u00a0<\/span>Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/strong>\u00a0to research institutions and wholesale buyers across the\u00a0<\/span>United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA<\/span><\/strong>. Every batch is lyophilised, HPLC-verified to \u226595% purity, and accompanied by a Certificate of Analysis (COA), ensuring your studies into cell growth, receptor pharmacology, and metabolic regulation begin with uncompromising quality.<\/span><\/p>\n

What Is Receptor Grade IGF-1 LR3 and How Does It Work?<\/span><\/h2>\n

To fully appreciate the research potential of\u00a0<\/span>Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/strong>, it is essential to understand its molecular design and the mechanism by which it achieves enhanced potency.<\/span><\/p>\n

The LR3 Modification: Structural Engineering for Enhanced Potency<\/span><\/h3>\n

LR3-IGF-1 is an 83-amino-acid analogue of human IGF-1<\/span>. It comprises the complete human IGF-1 sequence with two key modifications<\/span>:<\/span><\/p>\n

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    Arginine Substitution at Position 3:<\/span><\/strong>\u00a0The glutamic acid (Glu) at position 3 of native IGF-1 is replaced with arginine (Arg). This substitution is responsible for the “R3” designation and significantly reduces the peptide’s affinity for IGF-binding proteins<\/span>.<\/span><\/p>\n<\/li>\n

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    N-Terminal Extension:<\/span><\/strong>\u00a0A 13-amino-acid extension peptide is added at the N-terminus, further enhancing the peptide’s stability and biological activity<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

    These modifications result in an analogue with\u00a0<\/span>>100-fold reduced affinity for IGFBPs<\/span><\/strong>\u00a0compared to native IGF-1<\/span>. Since IGFBPs normally sequester and inhibit the biological actions of IGFs, this reduced binding translates directly into enhanced potency and a significantly prolonged half-life in cell culture and experimental models<\/span>.<\/span><\/p>\n

    Mechanism of Action: Sustained IGF-1 Receptor Activation<\/span><\/h3>\n

    The biological activity of\u00a0<\/span>Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/strong>\u00a0is rooted in its ability to provide sustained, high-level activation of the type 1 IGF receptor:<\/span><\/p>\n

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      Receptor Binding with Similar Affinity:<\/span><\/strong>\u00a0LR3-IGF-1 binds to the type 1 IGF receptor with affinity similar to that of wild-type IGF-1<\/span>.<\/span><\/p>\n<\/li>\n

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      Enhanced Signalling Activation:<\/span><\/strong>\u00a0Because it is not rapidly neutralised by IGFBPs, LR3-IGF-1 achieves a higher level of receptor occupancy and thus induces a more robust activation of intracellular signalling molecules<\/span>.<\/span><\/p>\n<\/li>\n

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      Downstream Pathway Activation:<\/span><\/strong>\u00a0This leads to potent activation of the\u00a0<\/span>PI3K\/AKT pathway<\/span><\/strong>\u00a0(promoting cell survival and inhibiting apoptosis) and\u00a0<\/span>ERK1\/2 signalling<\/span><\/strong>\u00a0(driving proliferation and differentiation)<\/span>.<\/span><\/p>\n<\/li>\n

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      Promotion of Cell Survival:<\/span><\/strong>\u00a0By activating these pathways, LR3-IGF-1 promotes cell survival through the inhibition of apoptosis<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

      Key Research Applications for Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/h2>\n

      Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/strong>\u00a0is a versatile tool with applications spanning several domains of cellular and molecular research.<\/span><\/p>\n

      Cell Proliferation & Survival Studies<\/span><\/h3>\n

      The most established application of LR3-IGF-1 is in studying the mechanisms of cell growth and proliferation across diverse mammalian cell lines<\/span>. By binding to the IGF-1 receptor and activating downstream signalling cascades, it enables researchers to dissect the molecular underpinnings of mitogenesis and survival<\/span>. Its enhanced resistance to IGFBPs ensures sustained receptor engagement, providing robust and reproducible stimulation in cell culture models<\/span>. This property is particularly advantageous in experiments aiming to elucidate the roles of growth factors in tissue development, cancer biology, and regenerative processes<\/span>.<\/span><\/p>\n

      \u00a0IGF Receptor & Signal Transduction Research<\/span><\/h3>\n

      The peptide’s capacity to activate IGF-1 receptor-mediated signalling makes it an indispensable reagent for probing intracellular pathways involved in metabolism, apoptosis, and gene expression<\/span>. Researchers frequently employ IGF-1 LR3 to delineate the differential effects of IGF-1 analogues on downstream effectors, providing insights into the specificity and redundancy of growth factor signalling<\/span>.<\/span><\/p>\n

      \u00a0Stem Cell & Regenerative Medicine Research<\/span><\/h3>\n

      IGF-1 LR3 is widely used in stem cell research to support the expansion and maintenance of various stem cell populations<\/span>. It has been shown to regulate lymphopoiesis by stimulating the proliferation and differentiation of T and B cells in lymphoid organs<\/span>. Together with other growth factors, IGF-I stimulates the differentiation and proliferation of myeloid cells<\/span>.<\/span><\/p>\n

      Neuroscience & Neuroprotection Research<\/span><\/h3>\n

      Emerging research has investigated LR3-IGF-1 in the context of neurological conditions. A 2024 study published in the\u00a0<\/span>Journal of Alzheimer’s Disease<\/span><\/em>\u00a0examined intranasal LR3-IGF-1 treatment in a mouse model of Alzheimer’s disease<\/span>. The study found that LR3 treatment promoted favourable effects on A\u03b2 plaque remodelling in the cortex<\/span>\u00a0and enhanced the uptake of A\u03b2 peptide by microglial cells\u00a0<\/span>in vitro<\/span><\/em>. While the study did not support LR3 as a monotherapy, it warranted further investigation into its potential for combinatorial formulations<\/span>.<\/span><\/p>\n

      Muscle, Bone & Cartilage Research<\/span><\/h3>\n

      As a mitogenic polypeptide growth factor, IGF-1 LR3 stimulates the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue\u00a0<\/span>in vitro<\/span><\/em>. Experimental infusion of LR3-IGF-1 into late-gestation fetal sheep has been shown to increase fetal organ growth and skeletal muscle myoblast proliferation<\/span>. This positions LR3-IGF-1 as a valuable tool for studying musculoskeletal development and regeneration.<\/span><\/p>\n

      Biopharmaceutical Manufacturing & Cell Culture Optimisation<\/span><\/h3>\n

      LR3-IGF-1 was specifically developed for supplementation of mammalian cell culture to support the survival and proliferation of cells<\/span>. Supplementation of cell cultures with LR3-IGF-1 at a much lower concentration results in equivalent or better productivity than supplementation with standard concentrations of insulin<\/span>. This makes it an ideal choice for both research and large-scale culturing of CHO, ES, NK, HSC, MSC, fibroblast, hybridomas, and many other cell types<\/span>.<\/span><\/p>\n

      Chemical & Physical Specifications<\/span><\/h2>\n

      Accurate characterisation of\u00a0<\/span>Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/strong>\u00a0is essential for reproducible experimental design. Below are the verified specifications from multiple research suppliers.<\/span><\/p>\n

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      <\/div>\n<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
      Parameter<\/span><\/th>\nSpecification<\/span><\/th>\n<\/tr>\n<\/thead>\n
      Common Names<\/span><\/strong><\/td>\nLR3-IGF-1, Long Arg3 IGF-1, IGF-I LR3<\/span><\/td>\n<\/tr>\n
      Amino Acid Sequence<\/span><\/strong><\/td>\n83-amino-acid analogue (human IGF-1 with R3 substitution + 13aa N-terminal extension)<\/span><\/td>\n<\/tr>\n
      Molecular Weight<\/span><\/strong><\/td>\n~9.1 kDa (9110.6 \u00b1 2 Da)<\/span><\/td>\n<\/tr>\n
      CAS Number<\/span><\/strong><\/td>\n946870-92-4<\/span><\/td>\n<\/tr>\n
      Purity<\/span><\/strong><\/td>\n\u226595%<\/span><\/strong>\u00a0(SDS-PAGE & HPLC)<\/span><\/td>\n<\/tr>\n
      Biological Activity<\/span><\/strong><\/td>\nED\u2085\u2080 \u2264 10 ng\/ml (L6 myoblast protein synthesis \/ CHO cell proliferation)<\/span><\/td>\n<\/tr>\n
      Endotoxin Level<\/span><\/strong><\/td>\n< 0.1 EU\/\u03bcg<\/span><\/td>\n<\/tr>\n
      Appearance<\/span><\/strong><\/td>\nWhite to off-white lyophilised powder<\/span><\/td>\n<\/tr>\n
      Source<\/span><\/strong><\/td>\nProduced in\u00a0<\/span>E. coli<\/span><\/em><\/td>\n<\/tr>\n
      Storage (Lyophilised)<\/span><\/strong><\/td>\n2\u20118\u00b0C for up to 2 years (as freeze-dried product)<\/span><\/td>\n<\/tr>\n
      Storage (Reconstituted)<\/span><\/strong><\/td>\n2\u20118\u00b0C for short-term use; single-use aliquots at \u201320\u00b0C for long-term storage<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
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      Note on Purity:<\/span><\/strong>\u00a0The 100\u202fmcg mass refers to the weight of the protein in its lyophilised form. Receptor Grade indicates a high-quality research reagent specifically developed for studies on cell growth, IGF receptors, and IGF-binding proteins<\/span>.<\/span><\/p>\n<\/blockquote>\n

      Reconstitution & Handling Protocol for Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/h2>\n

      Proper reconstitution of\u00a0<\/span>Receptor Grade IGF-1 LR3 (100mcg)<\/span><\/strong>\u00a0is critical for maintaining its structural integrity and biological activity. This protocol is designed for research use only.<\/span><\/p>\n

      Step 1 \u2013 Preparation<\/span><\/h3>\n