{"id":964,"date":"2026-05-25T03:50:12","date_gmt":"2026-05-25T03:50:12","guid":{"rendered":"https:\/\/wuhantopmiraclepeptides.com\/?post_type=product&p=964"},"modified":"2026-06-11T05:35:35","modified_gmt":"2026-06-11T05:35:35","slug":"thymosin-alpha-1","status":"publish","type":"product","link":"https:\/\/wuhantopmiraclepeptides.com\/index.php\/product\/thymosin-alpha-1\/","title":{"rendered":"Thymosin Alpha-1"},"content":{"rendered":"

Thymosin Alpha-1 Research Peptide: A Master Regulator for Immunology and Oncology Studies<\/span><\/h1>\n

If your laboratory focuses on immune modulation, viral pathogenesis or cancer immunotherapy, you already understand the need for well-characterised molecular tools.\u00a0<\/span>Thymosin Alpha-1 research peptide<\/span><\/strong>\u00a0(T\u03b11, thymalfasin) is a naturally occurring 28\u2011amino\u2011acid polypeptide first isolated from the thymus gland in 1977<\/span>. As the first biologically active peptide identified in the thymic preparation, fraction\u202f5, it has since become a cornerstone for studying T\u2011cell differentiation, immune restoration and the complex interplay between innate and adaptive immunity<\/span>.<\/span><\/p>\n

At Wuhan Top Miracle Peptides, we supply high-purity\u00a0<\/span>Thymosin Alpha-1 research peptide<\/span><\/strong>\u00a0to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy and the USA. Every batch is synthesised using solid\u2011phase peptide synthesis (SPPS), purified by preparative HPLC and validated by mass spectrometry to meet the rigorous quality standards demanded by the research community. Each shipment includes a Certificate of Analysis (COA) confirming \u226599% purity, ensuring your studies into immune reconstitution, infectious disease or tumour immunology begin with uncompromising quality.<\/span><\/p>\n

What Makes Thymosin Alpha-1 a Highly Versatile Research Tool?<\/span><\/h2>\n

Unlike many immunomodulators that target a single cell type or pathway,\u00a0<\/span>Thymosin Alpha-1 research peptide<\/span><\/strong>\u00a0exhibits true pleiotropy. It interacts with multiple components of the immune system, enhancing both innate and adaptive responses without triggering the uncontrolled inflammation associated with some immune agonists.<\/span><\/p>\n

A Naturally Occurring Peptide with Broad-Reaching Activity<\/span><\/h3>\n

The sequence of T\u03b11 is highly conserved across mammalian species, reflecting its fundamental role in immune homeostasis<\/span>. Its synthetic form, thymalfasin, has been approved by regulatory agencies in over 35 countries for the treatment of hepatitis\u202fB and as an immune enhancer in immunocompromised populations<\/span>.<\/span><\/p>\n

Molecular characteristics of Thymosin Alpha-1:<\/span><\/strong><\/p>\n

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    Structure:<\/span><\/strong>\u00a0A highly conserved 28\u2011amino\u2011acid acetylated polypeptide<\/span>.<\/span><\/p>\n<\/li>\n

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    Source:<\/span><\/strong>\u00a0Naturally produced by thymic epithelial cells and also found in spleen, lymph nodes, lung, kidney and brain<\/span>.<\/span><\/p>\n<\/li>\n

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    Biological relevance:<\/span><\/strong>\u00a0The deacetylated form exhibits substantially reduced activity, highlighting the importance of maintaining the correct modification during synthesis<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

    Mechanism of Action: From Toll\u2011Like Receptors to T\u2011Cell Function<\/span><\/h3>\n

    The immunomodulatory activity of\u00a0<\/span>Thymosin Alpha-1 research peptide<\/span><\/strong>\u00a0operates through several well\u2011characterised pathways:<\/span><\/p>\n

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      Toll\u2011Like Receptor (TLR) Activation:<\/span><\/strong>\u00a0T\u03b11 signals through TLR2 and TLR9 on innate immune cells, leading to activation of the NF\u2011\u03baB pathway and downstream cytokine production<\/span>.<\/span><\/p>\n<\/li>\n

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      T\u2011Cell Maturation and Differentiation:<\/span><\/strong>\u00a0The peptide enhances T\u2011cell function, increases the CD4+\/CD8+ ratio and blocks steroid\u2011induced apoptosis of thymocytes<\/span>.<\/span><\/p>\n<\/li>\n

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      Cytokine and Chemokine Modulation:<\/span><\/strong>\u00a0It up\u2011regulates Th1\u2011type cytokines (including IFN\u2011\u03b3) while suppressing excessive pro\u2011inflammatory mediators, restoring immune balance in chronic infection models<\/span>.<\/span><\/p>\n<\/li>\n

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      Macrophage Repolarisation:<\/span><\/strong>\u00a0T\u03b11 can reprogram tumour\u2011associated macrophages (TAMs) from an M2\u2011like (pro\u2011tumoural) toward an antitumoral phenotype<\/span>.<\/span><\/p>\n<\/li>\n<\/ul>\n

      Chemical & Physical Specifications<\/span><\/h2>\n

      Accurate characterisation of\u00a0<\/span>Thymosin Alpha-1 research peptide<\/span><\/strong>\u00a0is essential for reproducible experimental design.<\/span><\/p>\n

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      <\/div>\n<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
      Parameter<\/span><\/th>\nSpecification<\/span><\/th>\n<\/tr>\n<\/thead>\n
      Amino Acid Sequence<\/span><\/strong><\/td>\nAc\u2011Ser\u2011Asp\u2011Ala\u2011Ala\u2011Val\u2011Asp\u2011Thr\u2011Ser\u2011Ser\u2011Glu\u2011Ile\u2011Thr\u2011Thr\u2011Lys\u2011Asp\u2011Leu\u2011Lys\u2011Glu\u2011Lys\u2011Lys\u2011Glu\u2011Val\u2011Val\u2011Glu\u2011Glu\u2011Ala\u2011Glu\u2011Asn\u2011OH<\/span><\/td>\n<\/tr>\n
      Molecular Formula<\/span><\/strong><\/td>\nC\u2081\u2082\u2089H\u2082\u2081\u2085N\u2083\u2083O\u2085\u2085<\/span><\/td>\n<\/tr>\n
      Molecular Weight<\/span><\/strong><\/td>\n~3108.28 g\/mol<\/span><\/td>\n<\/tr>\n
      CAS Number<\/span><\/strong><\/td>\n62304\u201198\u20117<\/span><\/td>\n<\/tr>\n
      PubChem CID<\/span><\/strong><\/td>\n16130571<\/span><\/td>\n<\/tr>\n
      Purity<\/span><\/strong><\/td>\n\u226599% (HPLC verified)<\/span><\/td>\n<\/tr>\n
      Appearance<\/span><\/strong><\/td>\nWhite to off\u2011white lyophilised powder<\/span><\/td>\n<\/tr>\n
      Solubility<\/span><\/strong><\/td>\nSoluble in water at up to 2\u202fmg\/mL<\/span><\/td>\n<\/tr>\n
      Storage (Lyophilised)<\/span><\/strong><\/td>\n\u201320\u00b0C, sealed, protected from light; stable for up to 2 years<\/span><\/td>\n<\/tr>\n
      Storage (Reconstituted)<\/span><\/strong><\/td>\n2\u20138\u00b0C for up to 7 days; single\u2011use aliquots at \u201320\u00b0C for long\u2011term storage<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

      Key Research Applications for Thymosin Alpha\u20111<\/span><\/h2>\n

      Thymosin Alpha-1 research peptide<\/span><\/strong>\u00a0has been extensively investigated across a wide range of research areas, supported by more than 30 clinical trials involving over 11,000 human subjects<\/span>.<\/span><\/p>\n

      1. Immunology and T\u2011Cell Differentiation<\/span><\/h3>\n

      The most fundamental role of T\u03b11 lies in its ability to restore immune competence. Research demonstrates that\u00a0<\/span>Thymosin Alpha-1 research peptide<\/span><\/strong>\u00a0enhances the activity of T cells, dendritic cells (DCs) and natural killer (NK) cells while modulating cytokine and chemokine production<\/span>. In hematopoietic models, T\u03b11 promotes the differentiation of stem cells into functional CD28+ T\u2011cells, offering a tool for studying thymic involution and age\u2011related immune decline.<\/span><\/p>\n

      2. Viral Hepatitis and Infectious Disease<\/span><\/h3>\n

      T\u03b11 has been studied extensively in models of viral hepatitis. In hepatitis\u202fB virus\u2011related acute\u2011on\u2011chronic liver failure (HBV\u2011ACLF), T\u03b11 improves clinical outcomes by rebalancing the immune response\u2014mitigating excessive inflammation while preventing immune paralysis through modulation of T\u2011cell differentiation and cytokine production<\/span>. The peptide has also demonstrated activity against HIV\u20111, human T\u2011lymphotropic virus and human cytomegalovirus (HCMV) in vitro<\/span>.<\/span><\/p>\n

      3. Oncology and Immuno\u2011Oncology Research<\/span><\/h3>\n

      The immunomodulatory properties of\u00a0<\/span>Thymosin Alpha-1 research peptide<\/span><\/strong>\u00a0are increasingly being explored in cancer research. Key findings include:<\/span><\/p>\n