HGH Fragment 176-191 – A Selective 16‑Amino‑Acid Research Peptide for Metabolic Studies

HGH Fragment 176-191 is a synthetic 16‑amino‑acid peptide comprising the final segment of the human growth hormone (HGH) molecule, specifically the C-terminal region spanning residues 176 through 191. Unlike full‑length HGH, this fragment is designed to isolate the lipid‑modulating properties of the parent hormone without engaging growth‑promoting or broad metabolic pathways. It primarily functions by stimulating lipolysis (fat breakdown) and inhibiting lipogenesis (fat formation) in adipocytes, making it a valuable model for studying adipose tissue biology, energy homeostasis, and metabolic regulation.

If your research involves the study of adipocyte signalling, lipid metabolism, or endocrine pathways, you need a consistent, high‑purity source. Our wholesale service provides academic and private labs across the UK, Europe, and the USA with top‑grade peptides for sale, including HGH Fragment 176-191, all backed by transparent Certificates of Analysis (COAs). All products are supplied strictly for laboratory research use only.

 

Why Your Research Demands High‑Purity Peptides for Sale

The reliability of your experimental results hinges directly on the quality of your research materials. Our HGH Fragment 176-191 delivers:

• Verified Purity: Every batch undergoes rigorous HPLC and mass spectrometry testing, with purity levels consistently exceeding ≥98%. Independent third‑party testing (including two‑lab microbial contamination screening) is standard for every lot.

• Research‑Use Only: Exclusively for in‑vitro and laboratory applications. We never market it for human or veterinary consumption.

• Lyophilised Powder: Supplied as a stable, sterile, freeze‑dried solid in sealed, tamper‑evident packaging, ready for precise reconstitution according to your laboratory protocols.

• Complete Traceability: A batch‑specific Certificate of Analysis (COA) accompanies every order, verifying identity, purity (including HPLC and mass spectral data), and sterility testing results.

Choosing a supplier that prioritises peptide purity is fundamental for scientific integrity. Our seven‑point testing programme (analytical identity/purity plus additional quality verification per lot) ensures you can focus on your research, not on quality concerns.

 

 Scientific Background – Understanding HGH Fragment 176-191

HGH Fragment 176-191 is a synthetic peptide derived from the C‑terminal region of human growth hormone. This 16‑amino‑acid sequence has been identified as the biologically active domain responsible for many of the lipid‑metabolism regulatory effects attributed to the parent hormone.

Structural Specification

• Amino acid sequence: YLRIVQCRSVEGSCGF (Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe)

• Disulfide bridge: C7–C14 (cyclisation between Cys residues at positions 7 and 14)

• Molecular weight: Approximately 848 g/mol (calculated from the core structure) to 1817 g/mol (including the entire complex with counterions)

• Molecular formula: C₇₈H₁₂₅N₂₃O₂₃S₂

• CAS number: 66004‑57‑7 (free base)

• PubChem CID: 16131230

Primary Mechanism of Action

Unlike full‑length HGH, which broadly interacts with carbohydrate, protein, and lipid pathways, Fragment 176‑191 appears to target lipid metabolism primarily. Its proposed mechanism involves:

• Stimulation of Lipolysis: The peptide promotes the breakdown of triglycerides stored in adipocytes, leading to increased release of free fatty acids.

• Inhibition of Lipogenesis: It has been reported to suppress the transformation of non‑fat food materials into body fat.

• Receptor‑Independent Signalling: Unlike full HGH, this fragment does not significantly interact with growth hormone receptors associated with growth‑promoting pathways, potentially limiting undesirable cellular proliferation and preserving selectivity for metabolic effects.

• Adenylate Cyclase Pathway Activation: Research suggests the fragment stimulates cyclic AMP‑dependent pathways, thereby promoting lipid turnover in specific cell types.

Key Differentiator from AOD‑9604

AOD‑9604 (also known as Tyr‑hGH Frag 176‑191) is a structurally similar but distinct modified version that starts at amino acid 177 instead of 176 and includes modifications designed to enhance oral bioavailability. It is important to note that AOD‑9604 underwent six human clinical studies between 2001 and 2007, while the unmodified HGH Fragment 176‑191 has never been directly tested in published human clinical trials. All existing data on the unmodified fragment derive from animal trials or indirect evidence from studies of the AOD‑9604 analogue.

 

HGH Fragment 176-191 Research Applications

Based on its established mechanisms, HGH Fragment 176-191 is a valuable model for several areas of laboratory investigation:

 

Wholesale Peptides for Sale – Fast, Discreet Worldwide Shipping

A reliable supply chain is essential for uninterrupted research. Our network allows us to serve labs across the globe efficiently.

• United Kingdom – next‑day tracked delivery available (subject to Home Office and MHRA compliance)

• France, Germany, Spain, Sweden, Italy and other EU countries – fully compliant and reliable shipping

• United States of America – dependable delivery for American research institutions

For repeat‑order buyers and laboratory procurement teams, our wholesale program offers clear advantages:

•  Transparent, competitive bulk rates

•  A streamlined re‑ordering system that saves time and administrative burden

•  Discreet, fully tracked shipping on every single parcel

•  Dedicated account support for our regular wholesale customers

 

Understanding Peptide Purity for Your Application

All our HGH Fragment 176-191 lots meet the high‑purity standard necessary for serious laboratory work. We are fully transparent about all batch specifications, providing full analytical data including HPLC purity and mass spectral verification for every batch.

HGH Fragment 176‑191 Storage and Handling Guidelines

To preserve the integrity of this 16‑amino‑acid peptide:

• Upon receipt, store the lyophilised powder at ≤20 °C (short term) or ‑20 °C (long term), sealed, away from heat, light, and moisture.

• For short‑term storage (a few weeks), keep at 4 °C, protected from light.

• After reconstitution, aliquot immediately to avoid repeated freeze‑thaw cycles, which can degrade the peptide structure.

 

 Frequently Asked Questions (FAQ) about HGH Fragment 176‑191

 What is the amino acid sequence of HGH Fragment 176‑191?
The sequence is YLRIVQCRSVEGSCGF (Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe), with a disulfide bridge between the cysteine residues at positions 7 and 14.

How does HGH Fragment 176‑191 differ from full‑length HGH?
Full‑length HGH is a 191‑amino‑acid polypeptide with broad effects on growth, metabolism, and tissue repair. Fragment 176‑191 is a 16‑amino‑acid synthetic peptide that selectively targets lipid metabolism pathways without engaging growth‑promoting pathways or significantly interacting with growth hormone receptors.

 What is the relationship between HGH Fragment 176‑191 and AOD‑9604?
AOD‑9604 (also known as Tyr‑hGH Frag 176‑191) is a closely related modified version that starts at amino acid 177 instead of 176 and includes structural modifications to improve bioavailability. AOD‑9604 underwent human clinical trials between 2001 and 2007 and was found safe and well‑tolerated, though it failed to produce significant fat loss compared to placebo. The unmodified HGH Fragment 176‑191 has never been directly tested in published human clinical trials.

 What is the legal status of purchasing HGH Fragment 176‑191 in the United Kingdom?
Research peptides are legal to supply and purchase in the UK when explicitly sold for legitimate research purposes under “For Research Use Only” (RUO) labelling, and not marketed for human consumption or medicinal claims. As an authentic licensed peptide seller, we hold the necessary Home Office and MHRA authorisations to supply this compound exclusively for research applications.

Do you offer wholesale pricing for HGH Fragment 176‑191?
Yes. Wholesale is our core business. We serve universities, private research labs, and procurement teams worldwide. Please contact us directly for a custom quote tailored to your specific volume and frequency requirements.

 What documentation do you provide with each HGH Fragment 176‑191 order?
Every product we ship includes a batch‑specific Certificate of Analysis (COA). This document verifies the product’s identity via mass spectrometry, purity via HPLC, and sterility via third‑party independent testing (including two‑lab microbial contamination screening), ensuring complete traceability for your research records.

Is HGH Fragment 176‑191 suitable for in‑vitro research?
Yes. It is designed for controlled in‑vitro models and laboratory research into lipid metabolism, adipocyte signalling, and endocrine pathways. The peptide has been studied in numerous biochemical and metabolic investigations exploring the molecular mechanisms that regulate lipolysis and lipid accumulation in adipose tissues.

 Are there any known toxicity concerns for HGH Fragment 176‑191 in research models?
Animal studies have indicated that HGH Fragment 176-191 appears to have a favourable safety profile, with observed effects primarily related to lipid metabolism rather than broad hormonal disruption. The related analogue AOD‑9604 was found safe and well‑tolerated in human clinical trials, though it failed to demonstrate significant fat loss compared to placebo.

Where to Buy HGH Fragment 176-191in the UK

If you are searching for where to buy HGH Fragment 176-191 in the UK, Wuhan Top Miracle Peptides provides a simple process for research-focused and wholesale buyers.

How to Order

1. Review the HGH Fragment 176-191 product details.
2. Check the current product label and batch information.
3. Contact our team for availability.
4. Ask about wholesale pricing and COA information.
5. Confirm your shipping country.
6. Place your order with support from our team.

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Responsible Research Use Notice

HGH Fragment 176-191 is listed for research and professional supply purposes only. This page does not provide medical advice, treatment guidance, dosing instructions, injection instructions, fat-loss claims, bodybuilding claims, anti-ageing claims, or disease-related claims.

Avoid public claims that HGH Fragment 176-191 burns fat, improves metabolism, supports anti-ageing, builds muscle, improves performance, or treats any health condition. UK advertising rules for medicines, health-related products, and beauty products require careful handling of health claims.

 

Secure Your High‑Purity Peptides for Sale Today

Your research deserves the best possible foundation. Don’t let variable reagent quality compromise your findings. Wuhan Top Miracle Peptides provides a reliable wholesale service for peptides for sale, backed by an unwavering commitment to purity, full documentation (including third‑party independent testing), and fast shipping across the UK, Europe, and the USA.

With verified HGH Fragment 176-191 ready for immediate dispatch, you can advance your critical research into lipid metabolism, adipocyte signalling, or endocrine pathways without delay or compromise. All orders are handled with care, backed by complete Certificates of Analysis, and shipped discreetly in temperature‑controlled packaging.