Syn-Coll (Palmitoyl Tripeptide-5) (200mg): A Research Tool for Extracellular Matrix & TGF-β Signalling

If your research investigates extracellular matrix (ECM) biology, collagen synthesis, or the transforming growth factor-beta (TGF‑β) signalling pathway, Syn-Coll (Palmitoyl Tripeptide-5) (200mg) offers a precisely defined synthetic tool. Also known as Palmitoyl Tripeptide-5 or Pal‑KVK, this compound is a synthetic signal peptide consisting of three amino acids (lysine, valine, and lysine) conjugated to a palmitic acid moiety. This lipid modification enhances its stability, bioavailability, and membrane affinity, making it a valuable tool for studies of peptide-cell interactions, signal transduction, and extracellular matrix modulation.

At Wuhan Top Miracle Peptides, we supply high‑purity Syn-Coll (Palmitoyl Tripeptide-5) (200mg) to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥95% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into ECM biology, collagen synthesis, and TGF‑β signalling begin with uncompromising quality.

What Is Syn-Coll (Palmitoyl Tripeptide-5) and How Does It Work?

To fully appreciate the research potential of Syn-Coll (Palmitoyl Tripeptide-5) (200mg), it is essential to understand its biochemical design and the precise mechanism by which it modulates cellular signalling.

The Pal‑KVK Tripeptide

Syn-Coll (Palmitoyl Tripeptide-5) is a synthetic peptide composed of three amino acids—lysine, valine, and lysine—conjugated to a palmitic acid chain. Its sequence is Pal‑Lys‑Val‑Lys‑OH (Pal‑KVK). The palmitoyl group serves as a lipophilic anchor that facilitates membrane association and enhances peptide stability. The compound has a molecular weight of approximately 611.9 g/mol (free base) or 839.96 g/mol as the TFA salt, and a CAS number of 623172-56-5.

Mechanism of Action: TGF‑β Signalling & Collagen Synthesis

The biological activity of Syn-Coll (Palmitoyl Tripeptide-5) (200mg) is rooted in its ability to activate the TGF‑β signalling pathway:

• TGF‑β Pathway Activation: The peptide is thought to mimic the action of thrombospondin‑1, a natural activator of TGF‑β. By binding to cell surface receptors, it modulates downstream signalling pathways that regulate ECM components.

• Collagen Synthesis Stimulation: Through TGF‑β activation, the peptide induces the synthesis of Type I collagen in a dose‑dependent manner. It promotes the production of collagen and hyaluronic acid, supporting the skin’s extracellular matrix.

• Protection Against Collagen Degradation: The peptide helps protect against collagen degradation by modulating matrix metalloproteinases (MMPs).

• Fibroblast Activation: Researchers leverage its ability to interact with cell surface receptors and modulate downstream pathways, providing insights into the regulation of extracellular matrix components.

Key Research Applications for Syn-Coll (Palmitoyl Tripeptide-5)

Syn-Coll (Palmitoyl Tripeptide-5) (200mg) is a versatile tool with applications spanning several areas of biomedical and formulation research.

1. Extracellular Matrix & Collagen Synthesis Research

The most fundamental application of Syn-Coll lies in its ability to serve as a molecular probe for studying ECM biology. Its mechanism as a TGF‑β activator makes it a valuable tool for:

• Investigating the regulation of collagen synthesis in fibroblast cell culture models

• Studying the structure‑activity relationships in peptide signalling and the identification of molecular targets involved in tissue remodelling and cellular differentiation

• Exploring the modulation of ECM components such as collagen, elastin, and glycoproteins

• Examining the molecular mechanisms underlying tissue homeostasis, wound healing, and fibrosis

In vitro studies have confirmed that Palmitoyl Tripeptide‑5 effectively induces collagen I synthesis in a dose‑dependent pathway.

2. TGF‑β Signalling & Cellular Communication Research

As a TGF‑β pathway activator, Syn-Coll is a valuable tool for:

• Dissecting peptide‑mediated signalling mechanisms, particularly those involving collagen synthesis and fibroblast activation

• Investigating the regulation of extracellular matrix components through TGF‑β signalling

• Studying the impact of lipid modifications (palmitoylation) on peptide function and signalling

The compound’s amphiphilic nature facilitates membrane association, rendering it a favoured tool in research focused on cellular communication and peptide‑based functional assays.

3. Formulation & Transdermal Delivery Research

Syn-Coll is of significant interest in formulation science. Research has explored:

• Nanoparticle encapsulation: Supramolecular collagen nanoparticles encapsulating Palmitoyl Tripeptide‑5 (with an encapsulation rate of 93.18‑94.18%) have been developed, demonstrating enhanced transdermal efficacy and stability

• Microneedle delivery: Hyaluronic acid microneedle patches loaded with Palmitoyl Tripeptide‑5 have been studied for transdermal delivery

• Reverse micellar systems: A reverse micellar peptide nanosphere system has been developed to improve the skin accessibility and biological performance of Palmitoyl Tripeptide‑5

• Formulation stability: The peptide is water‑soluble and can be processed either cold or warm (up to 2 hours at 80°C)

Chemical & Physical Specifications for Syn-Coll (Palmitoyl Tripeptide-5) (200mg)

Accurate characterisation of Syn-Coll (Palmitoyl Tripeptide-5) (200mg) is essential for reproducible experimental design.

Note: The 200 mg mass refers to the weight of the peptide in its lyophilised form. The peptide is typically supplied as a TFA salt, which enhances aqueous solubility.

Reconstitution & Handling Protocol for Syn-Coll (Palmitoyl Tripeptide-5) (200mg)

Proper reconstitution of Syn-Coll (Palmitoyl Tripeptide-5) (200mg) is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed Syn-Coll vial and your chosen diluent (sterile bacteriostatic water, sterile PBS pH 5‑7, or dilute acetic acid) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Syn-Coll vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 200 mg per 20 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Syn-Coll into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles.

• Once thawed, store at 2‑8°C and use within 28 days.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements.

Storage & Stability Guidelines

Why Choose Wuhan Top Miracle Peptides for Syn-Coll (Palmitoyl Tripeptide-5) (200mg)?

As an authentic licensed peptide supplier based in the United Kingdom, we supply Syn-Coll (Palmitoyl Tripeptide-5) (200mg) and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥95% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised in ISO 13485:2016 and GMP‑certified facilities, ensuring batch‑to‑batch consistency.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• UK‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United Kingdom—including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Syn-Coll (Palmitoyl Tripeptide-5) (200mg)

What is Syn-Coll (Palmitoyl Tripeptide-5) (200mg)?
Syn-Coll (Palmitoyl Tripeptide‑5) is a synthetic signal peptide composed of three amino acids (lysine, valine, lysine) conjugated to a palmitic acid moiety. It is used in research to study TGF‑β signalling, collagen synthesis, and extracellular matrix modulation.

 What is the sequence and molecular weight of Syn-Coll?
The sequence is Pal‑Lys‑Val‑Lys‑OH (Pal‑KVK). Its molecular weight is approximately 611.9 g/mol (free base) or 839.96 g/mol (TFA salt).

What are the primary research applications for Syn-Coll?
Syn-Coll is used in extracellular matrix and collagen synthesis research, TGF‑β signalling and cellular communication studies, and formulation and transdermal delivery research.

What is the mechanism of action of Syn-Coll?
Syn-Coll activates the TGF‑β signalling pathway, mimicking the action of thrombospondin‑1. This induces collagen synthesis in a dose‑dependent manner and helps protect against collagen degradation.

What purity does your Syn-Coll (Palmitoyl Tripeptide-5) (200mg) meet?
Our Syn-Coll is tested to ≥95% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

How should I reconstitute Syn-Coll (Palmitoyl Tripeptide-5) (200mg)?
Reconstitute with sterile bacteriostatic water, sterile PBS (pH 5‑7), or dilute acetic acid. Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake.

How should I store reconstituted Syn-Coll?
Reconstituted Syn-Coll should be stored at 2‑8°C and used within 28 days. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is Syn-Coll (Palmitoyl Tripeptide-5) research peptide legal to purchase in the UK?
Yes. Syn-Coll is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Wuhan Top Miracle Peptides ship internationally?
Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.

Wholesale Syn-Coll (Palmitoyl Tripeptide-5) (200mg) Supply Across the UK and Europe

Wuhan Top Miracle Peptides supports wholesale peptide and cosmetic ingredient buyers in the United Kingdom and international markets.

We Support Enquiries From:

• United Kingdom
• France
• Germany
• Spain
• Sweden
• Italy
• USA
• Wider Europe

For larger Syn-Coll 200mg enquiries, contact our team before ordering. This helps confirm stock, wholesale pricing, documentation, shipping options, and buyer requirements.

Where to Buy Syn-Coll 200mg in the UK

If you are searching for where to buy Syn-Coll 200mg in the UK, Wuhan Top Miracle Peptides provides a simple research-focused enquiry process.

How to Order

1. Review the Syn-Coll 200mg product details.
2. Check the current label and batch information.
3. Confirm the INCI name or product identity from documentation.
4. Ask whether Palmitoyl Tripeptide-5 is confirmed on the COA.
5. Contact our team for availability.
6. Ask about COA and purity-related documentation.
7. Confirm your shipping country.
8. Discuss wholesale quantity requirements.
9. Place your enquiry with support from our team.

 

 

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From its design as a palmitoylated signal peptide to its well‑characterised role as a TGF‑β pathway activator, Syn-Coll (Palmitoyl Tripeptide-5) (200mg) provides a precisely defined platform for advanced extracellular matrix and signalling research. Its ability to stimulate collagen synthesis, protect against collagen degradation, and modulate fibroblast activity—supported by in vitro studies published in peer‑reviewed literature—makes it a valuable addition to any laboratory investigating ECM biology, TGF‑β signalling, or topical peptide science. By choosing high‑purity, lab‑verified Syn-Coll (Palmitoyl Tripeptide-5) (200mg) from Wuhan Top Miracle Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Syn-Coll (Palmitoyl Tripeptide-5) (200mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Syn-Coll delivered directly to your facility in the UK, EU, or USA.