Adipotide (FTPP) (10mg)

Adipotide (FTPP) (10mg) Research Peptide: A Targeted Proapoptotic Peptide for Adipose & Metabolic Studies

If your research investigates adipose tissue biology, vascular targeting, or the molecular mechanisms underlying metabolic regulation, Adipotide (FTPP) (10mg) research peptide offers a precisely defined synthetic tool with a unique and well‑characterised mechanism of action. Also known as FTPP (Fat‑Targeted Proapoptotic Peptide), Prohibitin‑Targeting Peptide‑1 (TP01), and HKPao, Adipotide is a bipartite peptidomimetic designed to selectively target the vasculature of white adipose tissue. It consists of a homing domain that binds to a prohibitin‑annexin A2 complex on adipose endothelial cells, coupled to a proapoptotic effector domain that disrupts mitochondrial membranes, leading to endothelial cell apoptosis and subsequent vascular ablation. This makes Adipotide (FTPP) (10mg) research peptide a valuable tool for laboratories investigating adipose tissue remodelling, obesity pathophysiology, angiogenesis, and metabolic disease.

At Wuhan Top Miracle Peptides, we supply high‑purity Adipotide (FTPP) (10mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥98% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into adipose biology, metabolic regulation, and vascular targeting begin with uncompromising quality.

What Is Adipotide (FTPP) and How Does It Work?

To fully appreciate the research potential of Adipotide (FTPP) (10mg) research peptide, it is essential to understand its biochemical structure and the precise mechanism by which it exerts its effects.

The Bipartite Peptidomimetic Structure

Adipotide is a synthetic bipartite molecule composed of two functional domains linked by a diglycine spacer. Its sequence is H‑Cys‑Lys‑Gly‑Gly‑Arg‑Ala‑Lys‑Asp‑Cys‑Gly‑Gly‑(D‑Lys‑Leu‑Ala‑Lys‑Leu‑Ala‑Lys)₂‑NH₂, with a disulfide bridge forming a cyclic structure. The molecular formula is C₁₁₁H₂₀₆N₃₆O₂₈S₂, with a molecular weight of approximately 2557.21 Da. It has a CAS number of 859216‑15‑2.

The peptide originated from the laboratory of Renata Pasqualini and Wadih Arap at the M.D. Anderson Cancer Center, building on a 2004 Nature Medicine paper that used phage‑display technology to screen for peptide sequences homing to white adipose vasculature. The approach builds on an earlier 1999 proof‑of‑concept demonstrating that a vascular‑homing peptide could be coupled to a proapoptotic effector domain to kill targeted endothelial cells.

Mechanism of Action: Vascular Targeting and Endothelial Apoptosis

The biological activity of Adipotide (FTPP) (10mg) research peptide is mediated through its unique bipartite design:

• Targeting Domain (CKGGRAKDC): The nine‑amino‑acid homing sequence CKGGRAKDC binds selectively to a protein complex involving prohibitin (PHB) and annexin A2 (ANXA2) on the luminal surface of endothelial cells feeding white adipose tissue. This receptor complex is enriched on adipose vasculature and plays a role in fatty acid transport.

• Proapoptotic Effector Domain (D(KLAKLAK)₂): Once internalised into endothelial cells, the effector domain disrupts mitochondrial membranes, triggering programmed cell death (apoptosis).

• Vascular Ablation and Adipose Tissue Reduction: The apoptotic death of adipose vasculature leads to vasoconstriction and shutdown of microvasculature within adipose tissue. This cuts off the blood supply — and therefore oxygen and nutrients — to white adipocytes, causing fat cells to wither and die. In preclinical studies, Adipotide resulted in approximately 30% weight reduction in obese mice over a period of 4 weeks.

Receptor Interactions and Fatty Acid Transport

Beyond vascular targeting, Adipotide’s mechanism is intertwined with recent findings about PHB and ANXA2 roles in fatty acid transport. The PHB‑ANXA2 interaction is present not only on vascular endothelium but also on adipocytes themselves. Disruption of PHB‑ANXA2 binding appears to reduce fatty acid uptake into adipose depots via the fatty acid transporter CD36. This suggests that Adipotide may indirectly modulate lipid influx into adipose tissue by targeting this network.

Research Note: A Distinct Mechanism from Incretin‑Based Approaches

Unlike GLP‑1 receptor agonists or other central‑acting weight loss peptides, Adipotide does not target appetite or the central nervous system. Instead, it acts directly on adipose tissue by disrupting its blood supply. This distinct mechanism of action — adipocytes are the target, apoptosis being the means to achieve fat reduction — positions Adipotide as a valuable tool for studying adipose biology through a pathway that is mechanistically orthogonal to incretin‑based therapies.

Key Research Applications for Adipotide (FTPP) (10mg)

Adipotide (FTPP) (10mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Adipose Tissue Biology & Obesity Research

As a peptide that selectively targets the vasculature of white adipose tissue, Adipotide is a valuable tool for studying adipose biology and obesity pathophysiology. Research applications include:

• Adipose Tissue Remodelling: Investigating how vascular ablation leads to adipose tissue mass reduction and altered adipocyte function.

• Subcutaneous vs. Visceral Fat: Exploring the differential targeting of subcutaneous and visceral fat depots.

• Energy Homeostasis: Studying the role of adipose vasculature in energy balance and metabolic regulation.

2. Metabolic & Diabetes Research

Adipotide has demonstrated significant effects on metabolic parameters in preclinical models. Research applications include:

• Insulin Sensitivity: Investigating how Adipotide improves glucose tolerance and insulin sensitivity. In obese adult mice, Adipotide treatment resulted in significantly improved insulin sensitivity and enhanced polysaccharide tolerance.

• Serum Triglycerides: Studies have shown reduced serum triglycerides following Adipotide treatment.

• Type 2 Diabetes Models: Exploring the peptide’s potential as a research tool for understanding the relationship between adipose tissue and diabetes.

3. Angiogenesis & Vascular Research

Adipotide’s reliance on vascular disruption positions it as a research tool for exploring angiogenesis in adipose and other tissues. Research applications include:

• Vascular Remodelling: Studying vascular remodelling in response to metabolic demands.

• Endothelial Cell Biology: Investigating the role of prohibitin and annexin A2 in endothelial cell function and fatty acid transport.

• Adipose Vasculature: Exploring the unique properties of adipose tissue vasculature and its role in metabolic regulation.

4. Oncology & Cancer Adjuvant Research

Adipotide has been investigated for its potential to reduce adipose tissue in severely obese cancer patients, which may improve subsequent chemotherapy outcomes. Research applications include:

• Obesity‑Associated Cancers: Studying the relationship between adipose tissue reduction and cancer progression.

• Adjuvant Therapy Models: Investigating whether targeted fat reduction improves chemotherapy efficacy.

5. Non‑Alcoholic Fatty Liver Disease (NAFLD) Research

Adipotide’s potential applications include research into non‑alcoholic fatty liver disease. Research applications include:

• Hepatic Steatosis: Investigating the effects of adipose tissue reduction on liver fat content.

• Metabolic Cross‑Talk: Studying the communication between adipose tissue and liver in metabolic disease.

Chemical & Physical Specifications

Accurate characterisation of Adipotide (FTPP) (10mg) research peptide is essential for reproducible experimental design.

Note: The 10 mg mass refers to the weight of the peptide in its lyophilised form. Adipotide is typically supplied as an acetate salt. The peptide is a bipartite peptidomimetic; the D‑amino acids in the effector domain (D‑Lys, D‑Leu, D‑Ala) confer resistance to proteolytic degradation. Adipotide is not FDA‑approved for human use and is supplied strictly for research use only (RUO).

Reconstitution & Handling Protocol for Adipotide (FTPP) (10mg)

Proper reconstitution of Adipotide (FTPP) (10mg) research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed Adipotide vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Adipotide vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 10 mg per 1 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Adipotide into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines

Why Choose Wuhan Top Miracle Peptides for Adipotide (FTPP) (10mg)?

As an authentic licensed peptide supplier based in the United Kingdom, we supply Adipotide (FTPP) (10mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥98% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• UK‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United Kingdom—including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: Adipotide (FTPP) (10mg) Research Peptide

What is Adipotide (FTPP) (10mg) research peptide?
Adipotide (FTPP, Prohibitin‑TP01, HKPao) is a synthetic bipartite peptidomimetic that selectively targets the vasculature of white adipose tissue via the prohibitin‑annexin A2 receptor complex. It comprises a homing domain (CKGGRAKDC) and a proapoptotic effector domain (D(KLAKLAK)₂).

What is the sequence and molecular weight of Adipotide?
The sequence is H‑Cys‑Lys‑Gly‑Gly‑Arg‑Ala‑Lys‑Asp‑Cys‑Gly‑Gly‑(D‑Lys‑Leu‑Ala‑Lys‑Leu‑Ala‑Lys)₂‑NH₂, with a disulfide bridge. Its molecular weight is approximately 2557.21 Da.

What are the primary research applications for Adipotide?
Adipotide is used in adipose tissue biology and obesity research, metabolic and diabetes research (insulin sensitivity, glucose tolerance), angiogenesis and vascular research, oncology and cancer adjuvant research, and NAFLD research.

What is the mechanism of action of Adipotide?
Adipotide binds to the prohibitin‑annexin A2 complex on adipose endothelial cells via its CKGGRAKDC targeting domain. Upon internalisation, the D(KLAKLAK)₂ effector domain disrupts mitochondrial membranes, triggering endothelial apoptosis. This cuts off the blood supply to white adipocytes, leading to fat cell death and adipose tissue reduction.

What preclinical evidence supports Adipotide’s efficacy?
In obese mice, Adipotide resulted in approximately 30% weight reduction over 4 weeks. In a rhesus macaque study, treated animals lost approximately 10.6% of body weight over 28 days, with an average fat mass reduction of almost 40%.

What purity does your Adipotide (FTPP) (10mg) meet?
Our Adipotide is tested to ≥98% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

How should I reconstitute Adipotide (FTPP) (10mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

How should I store reconstituted Adipotide?
Reconstituted Adipotide should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is Adipotide research peptide legal to purchase in the UK?
Yes. Adipotide is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims. Note: Adipotide is not FDA‑approved, has no approved indication, and has no legal pathway for human use in the United States. No human clinical data has been published as of 2026.

Does Wuhan Top Miracle Peptides ship internationally?
Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.

Wholesale Adipotide FTPP 10mg Supply Across the UK and Europe

Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.

We Support Enquiries From:

• United Kingdom
• France
• Germany
• Spain
• Sweden
• Italy
• USA
• Wider Europe

For larger Adipotide FTPP 10mg enquiries, contact our team before ordering. This helps confirm stock, documentation, shipping options, product identity, sequence details, vial strength, and buyer verification requirements.

Where to Source Adipotide FTPP 10mg in the UK

If you are searching for where to source Adipotide FTPP 10mg in the UK, Wuhan Top Miracle Peptides provides a simple professional enquiry process.

Professional Enquiry Process

1. Review the Adipotide FTPP 10mg product details.
2. Check the current label and batch information.
3. Confirm whether the batch is listed as Adipotide, FTPP, TP01, or another verified identity.
4. Ask about COA and purity-related documentation.
5. Confirm the sequence and salt form where required.
6. Confirm CAS number and storage notes where required.
7. Confirm your shipping country.
8. Discuss wholesale quantity requirements.
9. Complete buyer verification where required.
10. Place a professional enquiry with support from our team.

 

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From its origin as a phage‑display‑discovered homing peptide to its well‑characterised role in selectively targeting adipose vasculature, Adipotide (FTPP) (10mg) research peptide provides a precisely defined and mechanistically distinct platform for advanced adipose and metabolic research.

Its ability to induce endothelial apoptosis via the prohibitin‑annexin A2 receptor complex, thereby cutting off the blood supply to white adipocytes—supported by preclinical studies demonstrating significant weight loss and metabolic improvements in rodent and primate models—makes it a valuable addition to any laboratory investigating adipose tissue biology, obesity pathophysiology, vascular targeting, or metabolic regulation. By choosing high‑purity, lab‑verified Adipotide (FTPP) (10mg) research peptide from Wuhan Top Miracle Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with Adipotide (FTPP) (10mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Adipotide delivered directly to your facility in the UK, EU, or USA.