ABP-7 (10mg) Research Peptide: An Actin-Binding Heptapeptide for Cellular Migration & Wound Healing Studies

If your research investigates actin dynamics, cellular migration, or the molecular mechanisms of tissue repair, ABP-7 (10mg) research peptide — also known as Actin-Binding Peptide-7 — offers a precisely defined synthetic tool with a growing body of scientific literature. ABP-7 is a synthetic heptapeptide with the sequence Acetyl-LKKTETQ (Ac-LKKTETQ), identified as an N-acylated fragment (residues 17-23) of the larger 43‑amino‑acid molecule, Thymosin Beta 4 (Tβ4). As it contains the central actin-binding domain of Thymosin Beta 4, ABP-7 is considered a TB-500 fragment and is expected to mimic many of the functional properties of its parent molecule. This makes ABP-7 (10mg) research peptide a valuable tool for laboratories investigating cytoskeletal dynamics, wound healing, angiogenesis, fibrosis, and the molecular mechanisms underlying cellular motility.

At Wuhan Top Miracle Peptides, we supply high‑purity ABP-7 (10mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to >99% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into actin dynamics and tissue repair begin with uncompromising quality.

What Is ABP-7 and How Does It Work?

To fully appreciate the research potential of ABP-7 (10mg) research peptide, it is essential to understand its biochemical identity, its role as the central actin-binding domain of Thymosin Beta 4, and the mechanisms by which it exerts its effects.

The Ac-LKKTETQ Heptapeptide

ABP-7 is a synthetic heptapeptide consisting of seven amino acids, with the sequence Acetyl-LKKTETQ (Ac-LKKTETQ). Its molecular formula is C₃₈H₈₁N₉O₂₀, with a molecular weight of approximately 889.5 g/mol. It is produced via solid-phase peptide synthesis and is also known as the TB-500 Fragment. Researchers consider its LKKTETQ sequence to be the central actin-binding domain in Thymosin Beta 4.

Mechanism of Action: Actin Sequestration and Cytoskeletal Modulation

The biological activity of ABP-7 (10mg) research peptide is rooted in its function as an actin-binding protein, more specifically as an actin-sequestering site:

• Actin Sequestration and Cytoskeletal Dynamics: Thymosin Beta 4 is posited to function as an actin-binding protein, particularly through its domain ABP-7. This domain notably inhibits the polymerisation of globular actin (G-actin) into filamentous actin (F-actin), a process termed actin sequestration. By stabilising actin in its monomeric form, ABP-7 limits its availability to form the polymeric filaments necessary for a functional cytoskeleton.

• Impact on Cellular Migration and Motility: This alteration in the cytoskeletal architecture may impact the cell’s ability to migrate and adapt its shape. ABP-7 may support endothelial motility both by modulating actin polymerisation dynamics and by coupling these changes to extracellular remodelling enzymes. Interestingly, at the leading edge of migrating cells, ABP-7 apparently reduces its interaction with G-actin, which in turn allows polymerisation to proceed locally, suggesting a nuanced role in which sequestration and release are dynamically balanced to regulate directional movement.

• Promotion of Pseudopodia-Like Extensions: The ABP-7 peptide domain has been associated with the promotion of pseudopodia‑like extensions, structures that are generally viewed as key platforms for cellular exploration and motility.

Key Research Applications for ABP-7 (10mg)

ABP-7 (10mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Wound Healing and Dermal Regeneration Research

As the central actin-binding domain of Thymosin Beta 4, ABP-7 has been studied for its potential to promote wound repair. Research has demonstrated that the LKKTETQ peptide “was able to promote repair in the aged animals comparable to that observed with the parent molecule”. Research applications include:

• Keratinocyte Migration: ABP-7 is proposed to stimulate epidermal cell migration, which is central to re‑epithelialisation.

• Collagen Deposition: The peptide may increase collagen deposition at the wound site, potentially expediting wound closure and healing.

• Aged Tissue Models: Studies suggest that ABP-7 may compensate for cellular age-related deficits in migratory capacity.

• Endothelial Cell Support: ABP-7 may support endothelial cell migration, tube formation, and protease activity, suggesting a role in angiogenic processes necessary for wound repair.

2. Anti-Fibrotic and Hepatic Stellate Cell Research

ABP-7 has demonstrated potential anti‑fibrotic characteristics in preclinical research. Preliminary studies suggest that ABP-7 peptide “inhibits PDGF‑BB‑induced fibrogenesis, proliferation and migration of HSC by blocking Akt phosphorylation”. Research applications include:

• Hepatic Stellate Cell (HSC) Models: Investigating how ABP-7 inhibits PDGF‑BB‑induced fibrogenesis.

• Akt Phosphorylation Studies: Exploring how ABP-7 obstructs the phosphorylation of Akt at the T308 and S473 sites, which may subsequently impede the phosphorylation of PRAS40.

• Fibrosis Mitigation: Studying the potential of ABP-7 to reduce the proliferation and migration of activated HSCs and the subsequent fibrotic response.

3. Angiogenesis and Vascular Research

ABP-7 is thought to facilitate endothelial cell behaviours crucial for new blood vessel formation, such as migration and tube formation in vitro. Research applications include:

• Endothelial Cell Migration: Investigating how ABP-7 supports endothelial motility and tube formation.

• Vascular Remodelling: Exploring the peptide’s potential role in promoting angiogenesis.

• Protease Activity: Studying how ABP-7 couples cytoskeletal changes to extracellular remodelling enzymes.

4. Antimicrobial and Immune Modulation Research

ABP-7 has garnered attention within antimicrobial peptide research for its potential role in modulating microbial populations and contributing to innate defence-like mechanisms. Research applications include:

• Antimicrobial Activity: Investigating the peptide’s potential to alter microbial cell membranes.

• Immune Modulation: Exploring how ABP-7 might support the organism’s immune response by modulating cytokine production and cellular signalling pathways.

• Cellular Signalling: Studying the peptide’s influence on kinase‑related pathways, which are central to phosphorylation dynamics.

5. Metabolic and Neurobiological Research

Emerging research has speculated that ABP-7 may play a role in metabolic regulation, potentially impacting glucose uptake, lipid metabolism, or protein synthesis. Research applications include:

• Metabolic Regulation: Studying the peptide’s potential impact on glucose uptake and lipid metabolism.

• Neurobiology: Exploring the peptide’s alleged impact on neurobiology and cellular signalling.

Chemical & Physical Specifications

Accurate characterisation of ABP-7 (10mg) research peptide is essential for reproducible experimental design.

Note: The 10 mg mass refers to the weight of the peptide in its lyophilised form. ABP-7 is a synthetic peptide fragment of Thymosin Beta 4, containing the central actin‑binding domain of the parent molecule.

Reconstitution & Handling Protocol for ABP-7 (10mg)

Proper reconstitution of ABP-7 (10mg) research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed ABP-7 vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the ABP-7 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 10 mg per 1 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted ABP-7 into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines

Why Choose Wuhan Top Miracle Peptides for ABP-7 (10mg)?

As an authentic licensed peptide supplier based in the United Kingdom, we supply ABP-7 (10mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed >99% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• UK‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United Kingdom—including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: ABP-7 (10mg) Research Peptide

What is ABP-7 (10mg) research peptide?
ABP-7 (Actin-Binding Peptide-7) is a synthetic heptapeptide with the sequence Acetyl-LKKTETQ. It is an N-acylated fragment (residues 17-23) of Thymosin Beta 4 (Tβ4) and is also known as the TB-500 Fragment.

What is the sequence and molecular weight of ABP-7?
The sequence is Acetyl-LKKTETQ (Ac-LKKTETQ). Its molecular formula is C₃₈H₈₁N₉O₂₀, and its molecular weight is approximately 889.5 g/mol.

What are the primary research applications for ABP-7?
ABP-7 is used in wound healing and dermal regeneration research (keratinocyte migration, collagen deposition), anti‑fibrotic and hepatic stellate cell research (Akt phosphorylation inhibition), angiogenesis and vascular research (endothelial cell migration), antimicrobial and immune modulation research, and metabolic and neurobiological research.

What is the mechanism of action of ABP-7?
ABP-7 functions as an actin-sequestering site, binding globular actin (G‑actin) and mitigating its polymerisation into filamentous actin (F‑actin). This modulates the cytoskeletal architecture, impacting cell migration, shape adaptation, and dynamic remodelling.

How does ABP-7 relate to Thymosin Beta 4 and TB-500?
ABP-7 contains the central actin-binding domain of Thymosin Beta 4 (LKKTETQ). It is considered a fragment of TB-500 and is expected to have similar potential actions regarding actin binding. It is also known as the TB-500 Fragment.

What purity does your ABP-7 (10mg) meet?
Our ABP-7 is tested to >99% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

How should I reconstitute ABP-7 (10mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake.

How should I store reconstituted ABP-7?
Reconstituted ABP-7 should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is ABP-7 research peptide legal to purchase in the UK?
Yes. ABP-7 is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Wuhan Top Miracle Peptides ship internationally?
Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.

Wholesale ABP-7 10mg Supply Across the UK and Europe

Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.

We Support Enquiries From:

• United Kingdom
• France
• Germany
• Spain
• Sweden
• Italy
• USA
• Wider Europe

For larger ABP-7 10mg enquiries, contact our team before ordering. This helps confirm stock, documentation, shipping options, product identity, and buyer verification requirements.

Where to Source ABP-7 10mg in the UK

If you are searching for where to source ABP-7 10mg in the UK, Wuhan Top Miracle Peptides provides a simple professional enquiry process.

Professional Enquiry Process

1. Review the ABP-7 10mg product details.
2. Check the current label and batch information.
3. Confirm whether the batch is listed as ABP-7 or another verified identity.
4. Ask about COA and purity-related documentation.
5. Confirm the sequence and salt form where required.
6. Confirm CAS number and storage notes where required.
7. Confirm your shipping country.
8. Discuss wholesale quantity requirements.
9. Complete buyer verification where required.
10. Place a professional enquiry with support from our team.

 

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From its origin as the central actin-binding domain of Thymosin Beta 4 to its well‑characterised role in actin sequestration, cellular migration, wound healing, and anti‑fibrotic signalling, ABP-7 (10mg) research peptide provides a precisely defined and increasingly valuable platform for advanced cytoskeletal and tissue repair research. Its ability to modulate actin dynamics, promote keratinocyte and endothelial cell migration, and inhibit fibrogenic signalling pathways—supported by peer‑reviewed research published in PubMed and other authoritative journals—makes it a valuable addition to any laboratory investigating actin dynamics, wound healing, angiogenesis, fibrosis, or cellular motility. By choosing high‑purity, lab‑verified ABP-7 (10mg) research peptide from Wuhan Top Miracle Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with ABP-7 (10mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade ABP-7 delivered directly to your facility in the UK, EU, or USA.