AOD 9604 (5mg) Research Peptide: A Lipolytic Fragment for Metabolic & Regenerative Studies

If your research investigates lipid metabolism, adipose tissue signalling, or the molecular mechanisms of fat oxidation and cartilage repair, AOD 9604 (5mg) research peptide offers a precisely defined and increasingly well‑characterised synthetic tool. AOD 9604 is a synthetic peptide derived from the C‑terminal fragment of human growth hormone (hGH), specifically the 177‑191 amino acid sequence.

Also known as the GH fragment 176‑191, this 16‑amino‑acid peptide was engineered to selectively mimic the fat‑burning effects of hGH without the broader anabolic and metabolic effects associated with full‑length growth hormone. Unlike full hGH, AOD 9604 does not activate GH receptors and does not significantly impact insulin or IGF‑1 levels. This makes AOD 9604 (5mg) research peptide a valuable tool for laboratories investigating lipid metabolism, obesity, metabolic regulation, cartilage repair, and tissue regeneration.

At Wuhan Top Miracle Peptides, we supply high‑purity AOD 9604 (5mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥98% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into lipid metabolism, fat oxidation, and tissue regeneration begin with uncompromising quality.

What Is AOD 9604 and How Does It Work?

To fully appreciate the research potential of AOD 9604 (5mg) research peptide, it is essential to understand its biochemical structure and the mechanisms by which it exerts its effects.

The Modified C‑Terminal hGH Fragment

AOD 9604 is a synthetic peptide derived from the C‑terminal region of human growth hormone, specifically residues 177‑191 of the hGH molecule. The amino acid sequence is H2N‑Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe‑OH, which includes a disulfide bridge forming a cyclic structure. Its molecular formula is C₇₈H₁₂₃N₂₃O₂₃S₂, and its molecular weight is approximately 1815.0 g/mol. It has a CAS number of 221231-10-3.

The peptide was originally developed by Metabolic Pharmaceuticals in Australia as a potential anti‑obesity therapeutic. Early studies explored its role in adipose tissue metabolism and inflammation.

Mechanism of Action: Selective Lipolytic Signalling

The biological activity of AOD 9604 (5mg) research peptide is mediated through mechanisms distinct from full‑length hGH. Studies indicate that AOD 9604 does not compete for the hGH receptor nor induce cell proliferation through it.

• Lipolysis Stimulation: AOD 9604 promotes the breakdown of stored fat (lipolysis) in adipose tissue. It may activate beta‑3 adrenergic receptors in fat cells, leading to enhanced fat oxidation. The peptide enhances the expression of lipolytic enzymes such as hormone‑sensitive lipase (HSL) and adipose triglyceride lipase (ATGL).

• Lipogenesis Inhibition: AOD 9604 inhibits the formation of new fat deposits (lipogenesis), reducing fat accumulation.

• Metabolic Regulation: The peptide supports fat oxidation and energy expenditure without significantly affecting blood sugar regulation or insulin‑like growth factor‑1 (IGF‑1) levels. A 2008 study published in the Journal of Endocrinology found that GH fragment 176‑191 increased lipid oxidation in test systems and did not stimulate IGF‑1 or GH signalling like full GH.

• Anti‑Inflammatory and Regenerative Effects: Emerging research suggests AOD 9604 may support cartilage repair, joint recovery, and anti‑inflammatory effects, making it a potential tool for tissue regeneration studies. Its hypothesized impact on collagen synthesis and extracellular matrix remodelling suggests utility in wound healing and bone science research.

Key Research Applications for AOD 9604 (5mg)

AOD 9604 (5mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Lipid Metabolism & Adipose Tissue Research

As a peptide that selectively stimulates lipolysis and inhibits lipogenesis, AOD 9604 is a valuable tool for studying fat metabolism. Research applications include:

• Lipolysis Signalling Pathways: Investigating the molecular mechanisms that trigger the breakdown of triglycerides in adipocytes.

• Adipocyte Metabolism: Studying the regulation of lipid storage and mobilisation in adipose tissue.

• Fat Oxidation: Exploring how the peptide enhances fat oxidation and energy expenditure.

• Obesity Research: Investigating the peptide’s potential to impact energy expenditure and fat oxidation pathways in metabolic research.

2. Metabolic & Obesity Research

AOD 9604 has been proposed as a tool for investigating interventions to mitigate adiposity and support functional metabolic profiles. Research applications include:

• Weight Regulation: Studying the mechanisms underlying weight regulation and metabolic homeostasis.

• Metabolic Dysregulation: Exploring strategies for addressing metabolic dysregulation.

• Inflammatory Modulation: Investigating the relationship between inflammation and metabolic science, as AOD 9604’s anti‑inflammatory properties may offer a framework for novel research strategies.

3. Cartilage & Joint Research

AOD 9604 has demonstrated potential in cartilage repair and joint recovery research. Research applications include:

• Cartilage Regeneration: Studying the peptide’s potential role in cartilage repair and tissue healing.

• Joint Recovery: Exploring AOD 9604’s impact on post‑injury recovery and inflammation modulation.

• Osteoarthritis Models: Investigating the peptide’s potential to mitigate degenerative joint conditions.

4. Bone & Regenerative Research

AOD 9604 has been hypothesised to impact pathways involved in bone remodelling. Research applications include:

• Bone Remodelling: Studying the modulation of osteoblast and osteoclast activity.

• Bone Mineralisation: Investigating the peptide’s potential to support the mineralisation of bone.

• Collagen Synthesis: Exploring AOD 9604’s potential to support collagen synthesis and extracellular matrix remodelling.

Chemical & Physical Specifications

Accurate characterisation of AOD 9604 (5mg) research peptide is essential for reproducible experimental design.

Note: The 5 mg mass refers to the weight of the peptide in its lyophilised form. AOD 9604 is typically supplied as an acetate salt, which enhances aqueous solubility. The peptide is a synthetic lipolytic 16‑amino‑acid fragment derived from the C‑terminal region of human growth hormone.

Reconstitution & Handling Protocol for AOD 9604 (5mg)

Proper reconstitution of AOD 9604 (5mg) research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed AOD 9604 vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the AOD 9604 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 5 mg per 0.5 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted AOD 9604 into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines

Why Choose Wuhan Top Miracle Peptides for AOD 9604 (5mg)?

As an authentic licensed peptide supplier based in the United Kingdom, we supply AOD 9604 (5mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥98% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• UK‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United Kingdom—including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: AOD 9604 (5mg) Research Peptide

What is AOD 9604 (5mg) research peptide?
AOD 9604 is a synthetic lipolytic peptide derived from the C‑terminal region (residues 177‑191) of human growth hormone. It is a 16‑amino‑acid peptide fragment, also known as GH fragment 176‑191, that selectively mimics the fat‑burning effects of hGH without affecting insulin or IGF‑1 levels.

What is the sequence and molecular weight of AOD 9604?
The sequence is H2N‑Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe‑OH, with a disulfide bridge forming a cyclic structure. Its molecular weight is approximately 1815.0 g/mol.

What are the primary research applications for AOD 9604?
AOD 9604 is used in lipid metabolism and adipose tissue research, metabolic and obesity research, cartilage and joint research, and bone and regenerative research.

What is the mechanism of action of AOD 9604?
AOD 9604 promotes lipolysis (fat breakdown) and inhibits lipogenesis (fat formation) without activating hGH receptors. It may activate beta‑3 adrenergic receptors, enhancing fat oxidation. The peptide does not significantly impact insulin or IGF‑1 levels.

What purity does your AOD 9604 (5mg) meet?
Our AOD 9604 is tested to ≥98% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

How should I reconstitute AOD 9604 (5mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

How should I store reconstituted AOD 9604?
Reconstituted AOD 9604 should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is AOD 9604 research peptide legal to purchase in the UK?
Yes. AOD 9604 is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims. It is not FDA‑approved and is restricted by the World Anti‑Doping Agency (WADA) for athletic use.

Q9: Does Wuhan Top Miracle Peptides ship internationally?
Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.

Wholesale AOD 9604 5mg Supply Across the UK and Europe

Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.

We Support Enquiries From:

• United Kingdom
• France
• Germany
• Spain
• Sweden
• Italy
• USA
• Wider Europe

For larger AOD 9604 5mg enquiries, contact our team before ordering. This helps confirm stock, documentation, shipping options, product identity, and buyer verification requirements.

Where to Source AOD 9604 5mg in the UK

If you are searching for where to source AOD 9604 5mg in the UK, Wuhan Top Miracle Peptides provides a simple professional enquiry process.

Professional Enquiry Process

1. Review the AOD 9604 5mg product details.
2. Check the current label and batch information.
3. Confirm whether the batch is listed as AOD 9604, AOD9604, AOD-9604, or another verified identity.
4. Ask about COA and purity-related documentation.
5. Confirm the sequence and salt form where required.
6. Confirm whether the product is distinct from Fragment 176-191.
7. Confirm your shipping country.
8. Discuss wholesale quantity requirements.
9. Complete buyer verification where required.
10. Place a professional enquiry with support from our team.

 

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From its origin as a selectively engineered fragment of human growth hormone to its well‑characterised role in promoting lipolysis, inhibiting lipogenesis, and supporting cartilage repair, AOD 9604 (5mg) research peptide provides a precisely defined and increasingly valuable platform for advanced metabolic and regenerative research. Its ability to stimulate fat oxidation without activating hGH receptors or impacting IGF‑1 levels—supported by peer‑reviewed research published in the Journal of Endocrinology, Regulatory Toxicology and Pharmacology, and other authoritative journals—makes it a valuable addition to any laboratory investigating lipid metabolism, obesity, cartilage repair, or tissue regeneration.

By choosing high‑purity, lab‑verified AOD 9604 (5mg) research peptide from Wuhan Top Miracle Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with AOD 9604 (5mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade AOD 9604 delivered directly to your facility in the UK, EU, or USA.