HGH Fragment 176-191 (5mg) Research Peptide: A Lipolytic Fragment for Metabolic & Fat Metabolism Studies

If your research investigates lipid metabolism, adipocyte signalling, or the molecular mechanisms of fat breakdown, HGH Fragment 176-191 (5mg) research peptide — also known as AOD9604 — offers a precisely defined synthetic tool. This 16‑amino‑acid peptide corresponds to the C‑terminal region (residues 176‑191) of human growth hormone (HGH). Unlike full‑length HGH, this fragment selectively mimics the lipolytic activity of the parent hormone without significantly interacting with growth hormone receptors associated with growth‑promoting pathways. As a result, it stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat storage) without the adverse effects on blood sugar or growth. This makes HGH Fragment 176-191 (5mg) research peptide a valuable tool for laboratories investigating fat metabolism, obesity, adipocyte signalling, and metabolic regulation.

At Wuhan Top Miracle Peptides, we supply high‑purity HGH Fragment 176-191 (5mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥98% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into lipid metabolism and metabolic regulation begin with uncompromising quality.

What Is HGH Fragment 176-191 and How Does It Work?

To fully appreciate the research potential of HGH Fragment 176-191 (5mg) research peptide, it is essential to understand its biochemical structure and the mechanisms by which it exerts its effects.

The 16‑Amino‑Acid C‑Terminal Fragment

HGH Fragment 176-191 is a synthetic peptide corresponding to amino acids 176‑191 of the C‑terminal region of human growth hormone. Its sequence is H‑Tyr‑Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe‑OH (YLRIVQCRSVEGSCGF), with a disulfide bridge between Cys7 and Cys14. The peptide has a molecular formula of C₇₈H₁₂₅N₂₃O₂₃S₂ and a molecular weight of approximately 1815‑1817 g/mol. It has a CAS number of 66004‑57‑7.

The peptide is a synthetic C‑terminal fragment of HGH that retains many of the lipid‑metabolism regulatory effects of the parent hormone.

Mechanism of Action: Selective Lipolytic Signalling

The biological activity of HGH Fragment 176-191 (5mg) research peptide is mediated through its selective interaction with metabolic pathways:

• Stimulation of Lipolysis: The peptide promotes the breakdown of triglycerides stored in adipocytes, leading to increased release of fatty acids.

• Inhibition of Lipogenesis: It inhibits the transformation of non‑fat food materials into body fat.

• Receptor‑Independent Effects: Unlike full‑length HGH, Fragment 176‑191 does not significantly interact with growth hormone receptors associated with growth‑promoting pathways. It selectively mimics the lipolytic activity of HGH without the accompanying hyperglycemia.

• AMPK Pathway Modulation: The peptide is hypothesised to support signalling proteins associated with energy stress responses, including AMP‑activated protein kinase (AMPK).

Research Note: AOD9604 and Fragment 176‑191

Fragment 176‑191 is closely related to the peptide AOD9604, which shares the same amino acid sequence from positions 177‑191. AOD9604 has been described as a low‑affinity agonist of the GH receptor that retains some functions of GH without causing pro‑tumour or pro‑diabetic effects. Both peptides are believed to induce fat metabolism while increasing energy consumption, fat oxidation, and the generation of myoblasts.

Key Research Applications for HGH Fragment 176-191 (5mg)

HGH Fragment 176-191 (5mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Lipid Metabolism & Adipocyte Research

As a peptide that selectively stimulates lipolysis and inhibits lipogenesis, Fragment 176‑191 is a valuable tool for studying fat metabolism. Research applications include:

• Lipolysis Signalling Pathways: Investigating the molecular mechanisms that trigger the breakdown of triglycerides in adipocytes.

• Adipocyte Metabolism: Studying the regulation of lipid storage and mobilisation in adipose tissue.

• Lipid Accumulation: Exploring how the peptide inhibits lipid accumulation in adipocytes.

2. Obesity & Metabolic Disorder Research

Because the peptide influences fat metabolism pathways, it is frequently used in experimental models studying metabolic diseases and obesity. Research applications include:

• Adipose Tissue Regulation: Studying the metabolic regulation of adipose tissue.

• Obesity Development: Investigating the mechanisms of obesity development.

• Metabolic Syndrome: Exploring adipocyte differentiation and signalling in metabolic syndrome models.

3. Endocrinology & Hormone Signalling Research

The fragment provides a useful model for studying the structure‑function relationship of growth hormone and identifying biologically active domains within peptide hormones. Research applications include:

• Hormone Functional Domains: Analysing the specific domains responsible for metabolic effects.

• Receptor‑Independent Effects: Studying peptide hormone signalling pathways independent of the GH receptor.

• Hormone‑Derived Therapeutics: Investigating peptide‑based approaches for modulating lipid metabolism.

4. Drug Discovery & Therapeutic Research

The metabolic activity associated with the HGH 176‑191 region has prompted extensive investigation into peptide‑based approaches for modulating lipid metabolism. Research areas include:

• Peptide‑Based Therapeutics: Developing peptide‑based metabolic therapeutics.

• Obesity Treatment: Exploring peptide‑based approaches for obesity treatment research.

• Metabolic Pathway Modulation: Investigating the modulation of metabolic pathways.

5. Oncology Research

Recent research has explored the potential of Fragment 176‑191 in cancer research. A 2022 study demonstrated that the peptide enhances the toxicity of doxorubicin‑loaded chitosan nanoparticles against MCF‑7 breast cancer cells, suggesting a potential role in targeted cancer therapy. Research applications include:

• Targeted Drug Delivery: Investigating the use of Fragment 176‑191 to enhance tumour drug accumulation.

• Anticancer Efficacy: Studying the peptide’s ability to enhance the anti‑proliferative activity of chemotherapeutic agents.

Chemical & Physical Specifications

Accurate characterisation of HGH Fragment 176-191 (5mg) research peptide is essential for reproducible experimental design.

Note: The 5 mg mass refers to the weight of the peptide in its lyophilised form. HGH Fragment 176‑191 is typically supplied as a TFA or acetate salt, which enhances aqueous solubility.

Reconstitution & Handling Protocol for HGH Fragment 176-191 (5mg)

Proper reconstitution of HGH Fragment 176-191 (5mg) research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed Fragment 176‑191 vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the Fragment 176‑191 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 5 mg per 0.5 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted Fragment 176‑191 into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations may range from 0.1‑10 µM.

Storage & Stability Guidelines

Why Choose Wuhan Top Miracle Peptides for HGH Fragment 176-191 (5mg)?

As an authentic licensed peptide supplier based in the United Kingdom, we supply HGH Fragment 176-191 (5mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥98% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• UK‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United Kingdom—including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: HGH Fragment 176-191 (5mg) Research Peptide

What is HGH Fragment 176-191 (5mg) research peptide?
HGH Fragment 176-191 is a synthetic 16‑amino‑acid peptide corresponding to the C‑terminal region (residues 176‑191) of human growth hormone. It selectively mimics the lipolytic activity of HGH without the accompanying hyperglycemia or growth‑promoting effects.

What is the sequence and molecular weight of HGH Fragment 176‑191?
The sequence is H‑Tyr‑Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe‑OH (YLRIVQCRSVEGSCGF) with a disulfide bridge between Cys7 and Cys14. Its molecular weight is approximately 1815‑1817 g/mol.

What are the primary research applications for HGH Fragment 176‑191?
Fragment 176‑191 is used in lipid metabolism and adipocyte research (lipolysis signalling, lipid accumulation), obesity and metabolic disorder research, endocrinology and hormone signalling studies, drug discovery and therapeutic research, and oncology research (targeted drug delivery, anticancer efficacy).

What is the mechanism of action of HGH Fragment 176‑191?
The peptide stimulates lipolysis (breakdown of triglycerides in adipocytes) and inhibits lipogenesis (transformation of non‑fat materials into fat). Unlike full‑length HGH, it does not significantly interact with growth hormone receptors.

How does HGH Fragment 176‑191 differ from AOD9604?
Fragment 176‑191 is closely related to AOD9604, which shares the same amino acid sequence from positions 177‑191. Both peptides are believed to induce fat metabolism while increasing energy consumption and fat oxidation.

What purity does your HGH Fragment 176-191 (5mg) meet?
Our Fragment 176‑191 is tested to ≥98% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

How should I reconstitute HGH Fragment 176-191 (5mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

How should I store reconstituted HGH Fragment 176‑191?
Reconstituted Fragment 176‑191 should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

 Is HGH Fragment 176-191 research peptide legal to purchase in the UK?
Yes. HGH Fragment 176‑191 is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Wuhan Top Miracle Peptides ship internationally?
Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.

Wholesale Fragment 176-191 5mg Supply Across the UK and Europe

Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.

We Support Enquiries From:

• United Kingdom
• France
• Germany
• Spain
• Sweden
• Italy
• USA
• Wider Europe

For larger Fragment 176-191 5mg enquiries, contact our team before ordering. This helps confirm stock, documentation, shipping options, product identity, and buyer verification requirements.

Where to Source Fragment 176-191 5mg in the UK

If you are searching for where to source Fragment 176-191 5mg in the UK, Wuhan Top Miracle Peptides provides a simple professional enquiry process.

Professional Enquiry Process

1. Review the Fragment 176-191 5mg product details.
2. Check the current label and batch information.
3. Confirm whether the batch is listed as Fragment 176-191, HGH Fragment 176-191, hGH Fragment 176-191, or another verified identity.
4. Ask about COA and purity-related documentation.
5. Confirm the sequence and salt form where required.
6. Confirm your shipping country.
7. Discuss wholesale quantity requirements.
8. Complete buyer verification where required.
9. Place a professional enquiry with support from our team.

 

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From its identification as a biologically active C‑terminal fragment of human growth hormone to its well‑characterised role in stimulating lipolysis and inhibiting lipogenesis, HGH Fragment 176-191 (5mg) research peptide provides a precisely defined and increasingly valuable platform for advanced metabolic research. Its ability to selectively modulate fat metabolism without the hyperglycaemic or growth‑promoting effects of full‑length HGH—supported by peer‑reviewed research published in PubMed, MeSH, and other authoritative sources—makes it a valuable addition to any laboratory investigating lipid metabolism, adipocyte signalling, obesity, or metabolic regulation. By choosing high‑purity, lab‑verified HGH Fragment 176-191 (5mg) research peptide from Wuhan Top Miracle Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with HGH Fragment 176-191 (5mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade Fragment 176‑191 delivered directly to your facility in the UK, EU, or USA.