KPV (4mg) Research Peptide: An Anti-inflammatory Tripeptide for Immune & Wound Healing Studies

If your research explores inflammation pathways, immune modulation, or tissue repair, KPV (4mg) research peptide offers a precisely defined and increasingly well‑characterised synthetic tool. KPV (Lysine‑Proline‑Valine) is a tripeptide that represents the C‑terminal fragment (amino acids 11‑13) of alpha‑melanocyte‑stimulating hormone (α‑MSH). While α‑MSH is a larger hormone with melanotropic effects that can cause pigmentation, KPV retains the full anti‑inflammatory activity of the parent hormone but is free from its melanotropic effects. This makes KPV (4mg) research peptide a valuable tool for laboratories investigating inflammation, immune signalling, wound healing, and antimicrobial resistance.

At Wuhan Top Miracle Peptides, we supply high‑purity KPV (4mg) research peptide to research institutions and wholesale buyers across the United Kingdom, France, Germany, Spain, Sweden, Italy, and the USA. Every batch is lyophilised, HPLC‑verified to ≥98% purity, and accompanied by a Certificate of Analysis (COA), ensuring your investigations into inflammation, immune modulation, and tissue repair begin with uncompromising quality.

What Is KPV and How Does It Work?

To fully appreciate the research potential of KPV (4mg) research peptide, it is essential to understand its biochemical structure and the mechanisms by which it exerts its effects.

The Minimal Bioactive Tripeptide

KPV is a synthetic tripeptide with the sequence H‑Lys‑Pro‑Val‑OH (KPV). Its molecular formula is C₁₆H₃₀N₄O₄, and its molecular weight is approximately 342.43‑342.44 g/mol. It has a CAS number of 67727‑97‑3.

The peptide is derived from the C‑terminal region of α‑MSH. Unlike the full‑length hormone, KPV lacks the sequence motif required for binding to melanocortin receptors (MC‑Rs) yet still retains the full anti‑inflammatory effect of the parent molecule. It is smaller and more chemically stable than α‑MSH, making it a more robust research tool.

Mechanism of Action: IL‑1β Inhibition and NF‑κB Modulation

The biological activity of KPV (4mg) research peptide is mediated through a distinct mechanism that sets it apart from the full‑length α‑MSH hormone:

• IL‑1β Inhibition: Recent research indicates that KPV is unlikely to mediate its anti‑inflammatory effects through melanocortin receptors but is more likely to act through inhibition of IL‑1β functions. This distinguishes it from other α‑MSH‑derived peptides.

• NF‑κB Signalling Suppression: KPV suppresses NF‑κB signalling, inhibiting the nuclear import of p65RelA. It reduces the activity of nuclear factor kappa‑light‑chain‑enhancer of activated B cells (NF‑κB).

• Cytokine Modulation: The peptide decreases pro‑inflammatory cytokines such as TNF‑α and IL‑6.

• Epithelial MC3R Activation: KPV has been reported to activate epithelial MC3Rs in airway inflammation models.

Research Note: A Unique Anti‑Inflammatory Mechanism

Unlike α‑MSH, which signals through melanocortin receptors and increases cAMP accumulation, KPV does not increase cAMP. Its anti‑inflammatory effect is clearly different from that of core MSH peptides. This distinct mechanism makes KPV a valuable tool for dissecting the cellular signalling events that govern inflammatory responses.

Key Research Applications for KPV (4mg)

KPV (4mg) research peptide is a versatile tool with applications spanning several domains of biomedical research.

1. Inflammation & Immune Modulation Research

KPV is widely utilised in research exploring the molecular mechanisms of inflammation. Research applications include:

• Cytokine Pathway Studies: Investigating how KPV modulates pro‑inflammatory cytokines including IL‑1β, TNF‑α, and IL‑6.

• NF‑κB Signalling: Studying how KPV suppresses NF‑κB activation and nuclear translocation.

• Macrophage Activation: Exploring how KPV modulates macrophage activity and inflammatory responses.

• Inflammatory Disease Models: Investigating KPV’s potential in inflammatory bowel disease models.

2. Wound Healing & Tissue Repair Research

Recent findings demonstrate that KPV‑loaded hydrogels reduce inflammation, promote tissue regeneration, and combat MRSA infections. Research applications include:

• Corneal Wound Healing: Studies have shown that KPV facilitates corneal epithelial wound healing in rabbits. In one study, 100% of KPV‑treated corneas were completely re‑epithelised within 60 hours.

• Skin Regeneration: KPV accelerates wound healing, reduces infection, and promotes the barrier repair of skin or mucosa.

• Collagen Synthesis: The peptide accelerates the synthesis of collagen.

• Antimicrobial Activity: KPV‑loaded hydrogels combat MRSA infections.

3. Gastrointestinal & Inflammatory Bowel Disease Research

KPV has been investigated for its potential in inflammatory bowel disease models:

• Colitis Models: KPV has demonstrated anti‑inflammatory effects on colitis in murine models.

• Colitis‑Associated Cancer: Studies suggest that KPV may help prevent carcinogenesis in a murine model.

• Oral Bioavailability: The peptide is orally bioavailable.

4. Antimicrobial & Biofilm Research

KPV exhibits broad‑spectrum antimicrobial properties:

• MRSA Infections: KPV‑loaded formulations combat MRSA infections.

• Antimicrobial Peptide Research: The peptide has direct antimicrobial effects against fungi, mould, bacteria, viruses, and parasites.

• Biofilm Disruption: KPV demonstrates antibiofilm properties.

Chemical & Physical Specifications

Accurate characterisation of KPV (4mg) research peptide is essential for reproducible experimental design.

Note: The 4 mg mass refers to the weight of the peptide in its lyophilised form. KPV is typically supplied as a TFA or acetate salt, which enhances aqueous solubility. The peptide’s stability and biological activity have made it a subject of considerable interest in biochemical research.

Reconstitution & Handling Protocol for KPV (4mg)

Proper reconstitution of KPV (4mg) research peptide is critical for maintaining its structural integrity and biological activity.

Step 1 – Preparation

• Bring the sealed KPV vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5‑7) to room temperature. Condensation can degrade the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the KPV vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw your desired volume of diluent into a sterile syringe. A common starting concentration for research applications is 4 mg per 0.4 mL of diluent, yielding a 10 mg/mL stock solution.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted KPV into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles, as peptides are susceptible to degradation.

• Once thawed, store at 2‑8°C and use within a short period.

Concentration Reference Table

Adjust diluent volume based on your experimental requirements. For cell culture applications, typical working concentrations range from 0.1‑10 µM.

Storage & Stability Guidelines

Why Choose Wuhan Top Miracle Peptides for KPV (4mg)?

As an authentic licensed peptide supplier based in the United Kingdom, we supply KPV (4mg) research peptide and a wide range of research‑grade compounds under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards (Experience, Expertise, Authoritativeness, Trustworthiness).

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥98% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised under strict quality control conditions.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions, laboratories, and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• UK‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the United Kingdom—including those at leading institutions in London, Cambridge, Oxford, Manchester, and Edinburgh—trust us for fast domestic delivery, transparent documentation and professional technical support.

FAQ: KPV (4mg) Research Peptide

What is KPV (4mg) research peptide?
KPV (Lysine‑Proline‑Valine) is a synthetic tripeptide corresponding to the C‑terminal fragment (amino acids 11‑13) of α‑melanocyte‑stimulating hormone (α‑MSH). It retains the full anti‑inflammatory activity of α‑MSH but is free from melanotropic effects.

What is the sequence and molecular weight of KPV?
The sequence is H‑Lys‑Pro‑Val‑OH (KPV). Its molecular formula is C₁₆H₃₀N₄O₄, and its molecular weight is approximately 342.43‑342.44 g/mol.

 What are the primary research applications for KPV?
KPV is used in inflammation and immune modulation research (IL‑1β inhibition, NF‑κB suppression), wound healing and tissue repair studies (corneal wound healing, skin regeneration), gastrointestinal and inflammatory bowel disease research, and antimicrobial and biofilm research.

What is the mechanism of action of KPV?
KPV is unlikely to mediate its effects through melanocortin receptors but is more likely to act through inhibition of IL‑1β functions. It suppresses NF‑κB signalling, inhibits nuclear import of p65RelA, and decreases pro‑inflammatory cytokines such as TNF‑α and IL‑6.

 How does KPV differ from α‑MSH in research?
Unlike α‑MSH, which signals through melanocortin receptors and increases cAMP accumulation, KPV does not increase cAMP. KPV lacks the entire sequence motif required for binding to melanocortin receptors but still retains the full anti‑inflammatory effect of α‑MSH.

 What purity does your KPV (4mg) meet?
Our KPV is tested to ≥98% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

How should I reconstitute KPV (4mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject the diluent against the inner glass wall and swirl gently. Do not shake. A typical starting concentration is 10 mg/mL.

How should I store reconstituted KPV?
Reconstituted KPV should be stored at 2‑8°C for short‑term use. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is KPV research peptide legal to purchase in the UK?
Yes. KPV is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the United Kingdom for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

Does Wuhan Top Miracle Peptides ship internationally?
Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.

Wholesale KPV 4mg Supply Across the UK and Europe

Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.

We Support Enquiries From:

• United Kingdom
• France
• Germany
• Spain
• Sweden
• Italy
• USA
• Wider Europe

For larger KPV 4mg enquiries, contact our team before ordering. This helps confirm stock, documentation, shipping options, product identity, and buyer verification requirements.

Where to Source KPV 4mg in the UK

If you are searching for where to source KPV 4mg in the UK, Wuhan Top Miracle Peptides provides a simple professional enquiry process.

Professional Enquiry Process

1. Review the KPV 4mg product details.
2. Check the current label and batch information.
3. Confirm whether the batch is listed as KPV, KPV tripeptide, Lys-Pro-Val, or another verified identity.
4. Ask about COA and purity-related documentation.
5. Confirm the sequence and salt form where required.
6. Confirm your shipping country.
7. Discuss wholesale quantity requirements.
8. Complete buyer verification where required.
9. Place a professional enquiry with support from our team.

 

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From its discovery as the minimal bioactive fragment of α‑MSH to its well‑characterised role as a potent inhibitor of IL‑1β and NF‑κB signalling, KPV (4mg) research peptide provides a precisely defined and increasingly valuable platform for advanced inflammation and immune research. Its ability to modulate pro‑inflammatory cytokines, promote wound healing, and combat MRSA infections—supported by peer‑reviewed studies published in PubMed, PMC, and ScienceDirect—makes it a valuable addition to any laboratory investigating inflammation pathways, immune modulation, or tissue repair. By choosing high‑purity, lab‑verified KPV (4mg) research peptide from Wuhan Top Miracle Peptides, you ensure that your research is built on a foundation of quality, reproducibility, and scientific integrity.

Ready to advance your research with KPV (4mg)? Browse our product catalogue, request a wholesale quote, or contact our support team today to discuss your laboratory’s specific needs. Place your order now and receive GMP‑grade KPV delivered directly to your facility in the UK, EU, or USA.