PT-141  (10mg)– Melanocortin Receptor Peptide

PT-141 (Bremelanotide) is a cyclic synthetic peptide that acts as a melanocortin receptor agonist. It targets MC3R and MC4R receptors in the brain, which are involved in regulating sexual arousal and energy balance. Originally derived from the metabolism of melanotan II, PT-141 is studied for its ability to increase sexual desire and physiological responses in research models. At China Grey Peptides, our PT-141 (10mg) is lab-tested for >99% purity and designed for rigorous laboratory research.

What is PT-141 (10mg) (Bremelanotide) ?

• Peptide Structure: PT-141 is a cyclic peptide composed of seven amino acids. It is an analog of the natural melanocortin hormone α-MSH.
• Mechanism of Action: PT-141 activates MC3R and MC4R melanocortin receptors. This activation in the hypothalamus can stimulate pathways related to sexual arousal. MC4R activation, in particular, has been linked to increased sexual desire and arousal in studies.
• Biological Role: In research studies, PT-141 was shown to enhance sexual desire without significantly affecting blood pressure. These effects suggest it modulates central nervous system circuits tied to libido.
• Research Background: PT-141 became the basis for Vyleesi, an FDA-approved treatment for female sexual dysfunction, highlighting its potency. We emphasize that our PT-141 is for research use only.

Product Specification & Research Data Sheet

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Key Research Applications & Mechanism of Action

Mechanism of Action

PT-141 is a synthetic cyclic heptapeptide that acts as a potent melanocortin receptor agonist. Specifically, it targets MC4R (EC₅₀≈0.6 nM) and MC3R, bypassing the melanogenic pathway to exert central effects. It works by binding to melanocortin receptors in hypothalamic regions such as the medial preoptic area (mPOA), where it is hypothesised to promote dopamine release. This can provide insights into CNS receptor pharmacology and its role in neurochemical pathways.

Regulatory Status & Research Value

Understanding its clinical backdrop is essential for any laboratory study. PT-141 received FDA approval in 2019 for use in premenopausal women, which marks it as a unique pharmacological tool. This clinical use (outside of the lab) has produced well-documented pharmacokinetic data, such as a half-life of approximately 2.7 hours, that can help inform research protocols.

Neuroscience & Neurochemistry Research

Beyond its sexual behaviour niche, PT-141 serves as a specific molecular probe for investigating melanocortin receptor signalling cascades. It is used to explore how MC3R and MC4R activation influences neural circuits, offering a tool for dissecting pathways associated with appetite control, metabolic signalling, and stress responses.

Receptor Pharmacology & Preclinical Models

PT-141 is a valuable tool for in vitro and in vivo studies examining receptor activation. Preclinical research has documented its ability to induce specific behavioural responses in models without causing generalised motor activation or altering reward perception. This suggests a targeted receptor selectivity that can aid in distinguishing central melanocortin effects from peripheral or off-target ones.

Reconstitution & Handling Protocol

Proper reconstitution of PT‑141 (10mg) is critical for preserving the structural integrity and activity of this cyclic peptide. This aseptic protocol ensures optimal stability for your experiments.

Step 1 – Preparation

• Bring the sealed peptide vial and your chosen diluent (sterile bacteriostatic water or sterile PBS, pH 5–7) to room temperature. Allowing the vial to reach room temperature before opening prevents condensation from degrading the lyophilised powder.

• Clean your work surface with 70% ethanol and lay out sterile syringes, alcohol wipes, and a clean work mat.

Step 2 – Vial Sanitisation

• Wipe the rubber stopper of the PT‑141 vial with a fresh 70% ethanol wipe. Allow the alcohol to evaporate completely before piercing.

Step 3 – Reconstitution

• Draw 1.0 mL of sterile diluent into a sterile syringe. This will yield a standard research concentration of 10 mg/mL.

• Insert the needle and slowly inject the diluent against the inner glass wall. Do not spray directly onto the lyophilised powder.

• Gently swirl the vial until the solution is clear and fully dissolved. Do not shake vigorously, as shaking can cause denaturation.

Step 4 – Aliquoting & Storage

• Immediately after dissolution, aliquot the reconstituted peptide into single‑use sterile vials.

• Store aliquots at –20°C. Avoid repeated freeze‑thaw cycles.

• Once thawed, store at 2‑8°C and use within 7 days. For longer storage, maintain frozen at –20°C and avoid refreezing after thawing.

Concentration Reference Table for PT-141 (10mg)

Adjust diluent volume based on your experimental requirements.

Storage & Stability Guidelines for PT-141 (10mg)

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Why Choose Wuhan Top Miracle Peptides for Your PT-141 (10mg) Research?

As an authentic licensed peptide supplier based in the United Kingdom, we supply PT‑141 (10mg) under rigorous quality assurance protocols, fully aligned with Google’s E‑E‑A‑T standards.

• Verified Purity: Independent HPLC analysis with purity guaranteed ≥99% for every batch.

• GMP‑Compliant Manufacturing: All peptides are synthesised in ISO 13485:2016 and GMP‑certified facilities, ensuring batch‑to‑batch consistency.

• Full Traceability: Batch‑specific Certificates of Analysis (COA) are available for every order.

• Wholesale Supply: We serve research institutions and wholesale buyers across the UK, EU, and USA with flexible volume pricing and reliable logistics.

• UK‑Based Regulatory Compliance: All products are supplied strictly as research‑grade chemicals for laboratory use only (RUO).

Researchers across the UK — including those at leading institutions in London, Cambridge, and Oxford — trust us for fast domestic delivery, transparent documentation, and professional technical support.

FAQ: PT-141 (10mg) Research Peptide

 What is PT‑141?
PT‑141 is a synthetic cyclic heptapeptide that binds to and activates melanocortin receptors (primarily MC4R and MC3R) in the brain’s hypothalamus. It is used strictly as a laboratory research tool for neuroscience, neurochemistry, and receptor pharmacology studies.

 Is PT‑141 the same as bremelanotide?
Yes, PT‑141 is the research designation for the compound also known as bremelanotide or Vyleesi. All refer to the same synthetic cyclic peptide.

 What purity does your PT‑141 (10mg) meet?
Our PT‑141 is tested to ≥99% purity by HPLC. A Certificate of Analysis (COA) is supplied with every order.

How should I reconstitute PT‑141 (10mg)?
Reconstitute with sterile bacteriostatic water or sterile PBS (pH 5‑7). Allow the vial to reach room temperature, then slowly inject 1 mL of diluent against the inner glass wall. Swirl gently — do not shake.

 How should I store reconstituted PT‑141?
Reconstituted PT‑141 should be stored at 2‑8°C and used within 7 days. For longer storage, aliquot immediately into single‑use vials and store at –20°C for up to 3 months. Avoid repeated freeze‑thaw cycles.

Is PT‑141 legal to purchase in the UK for research?
Yes. PT‑141 is a laboratory reagent sold for research use only (RUO). It is fully legal to purchase, possess, and use in the UK for legitimate in‑vitro or in‑vivo scientific research, provided it is not marketed with therapeutic claims.

 What does “central‑acting” mean in research terms?
Unlike agents that act peripherally (e.g., on vascular smooth muscle), “central‑acting” means the compound is hypothesised to cross the blood‑brain barrier and directly influence neural pathways in the brain, making it a tool for studying CNS receptor pharmacology.

Does Wuhan Top Miracle Peptides ship internationally?
Yes. We ship across the EU (France, Germany, Spain, Sweden, Italy) and to the USA from our UK warehouse. Wholesale pricing is available for bulk orders.

Wholesale PT-141 10mg Supply Across the UK and Europe

Wuhan Top Miracle Peptides supports wholesale peptide buyers in the United Kingdom and international markets.

We Support Enquiries From:

• United Kingdom
• France
• Germany
• Spain
• Sweden
• Italy
• USA
• Wider Europe

For larger PT-141 10mg enquiries, contact our team before ordering. This helps confirm stock, wholesale pricing, documentation, shipping options, and buyer verification requirements.

Where to Source PT-141 10mg in the UK

If you are searching for where to source PT-141 10mg in the UK, Wuhan Top Miracle Peptides provides a simple professional enquiry process.

Professional Enquiry Process

1. Review the PT-141 10mg product details.
2. Check the current label and batch information.
3. Confirm the product identity from documentation.
4. Contact our team for availability.
5. Ask about COA and purity-related documentation.
6. Confirm your shipping country.
7. Discuss wholesale quantity requirements.
8. Complete buyer verification where required.

 

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Order PT-141 (10mg) Today

Advance your sexual health and metabolic research with high-quality PT-141 (10mg). Our peptide delivers verified 99%+ purity and consistent bioactivity. With fast USA shipping and complete documentation, China Grey Peptides is your trusted partner for research peptides. Order now or contact us for bulk pricing – work with a licensed peptide supplier that puts quality first.